©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Feb 4, 2015; 4(1): 1-12
Published online Feb 4, 2015. doi: 10.5492/wjccm.v4.i1.1
Published online Feb 4, 2015. doi: 10.5492/wjccm.v4.i1.1
Modeling cardiac arrest and resuscitation in the domestic pig
Brandon H Cherry, Anh Q Nguyen, Roger A Hollrah, Albert H Olivencia-Yurvati, Robert T Mallet, Department of Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, United States
Brandon H Cherry, Anh Q Nguyen, Roger A Hollrah, Robert T Mallet, Department of Integrative Physiology and Anatomy Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, United States
Brandon H Cherry, Robert T Mallet, Institute of Aging and Alzheimer’s Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107, United States
Albert H Olivencia-Yurvati, Department of Surgery Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, United States
Author contributions: Cherry BH, Nguyen AQ, Hollrah RA and Mallet RT researched the literature, wrote and edited the manuscript and prepared the figures; Olivencia-Yurvati AH reviewed and edited the manuscript for clinical accuracy.
Supported by Grants from The United States National Institute of Neurological Disorders and Stroke, No. R01 NS076975-03; a predoctoral fellowship from the United States National Institute of Aging, Training in the Neurobiology of Aging, No. T31 AG020494; and a predoctoral fellowship from the University of North Texas Health Science Center’s Physician Scientist Program.
Conflict-of-interest: The authors declare that they have no competing interests.
Correspondence to: Robert T Mallet, PhD, Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, United States. robert.mallet@unthsc.edu
Telephone: +1-817-7352260 Fax: +1-817-7355084
Received: August 8, 2014
Peer-review started: August 8, 2014
First decision: October 31, 2014
Revised: November 3, 2014
Accepted: November 27, 2014
Article in press: November 27, 2014
Published online: February 4, 2015
Processing time: 187 Days and 14.7 Hours
Peer-review started: August 8, 2014
First decision: October 31, 2014
Revised: November 3, 2014
Accepted: November 27, 2014
Article in press: November 27, 2014
Published online: February 4, 2015
Processing time: 187 Days and 14.7 Hours
Core Tip
Core tip: Cardiac arrest remains a leading cause of death worldwide, despite tremendous improvements in emergency medical care and increased public delivery of bystander cardiopulmonary resuscitation (CPR). But progress is being achieved, thanks to the joint efforts of biomedical scientists, physicians and emergency medical personnel to translate laboratory discoveries to the ambulance and hospital. The domestic pig has proven to be a superb preclinical model of cardiac arrest, yielding a wealth of mechanistic insights and practical strategies to refine the delivery of CPR and to test promising treatments. This review examines pivotal factors in modeling cardiac arrest and CPR in the pig.