Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Crit Care Med. Sep 9, 2026; 15(3): 117566
Published online Sep 9, 2026. doi: 10.5492/wjccm.117566
Published online Sep 9, 2026. doi: 10.5492/wjccm.117566
Global evidence on molecular adsorbent recirculating system uses for trauma-induced acute liver failure: A scoping review
Marcelo Augusto Fontenelle Ribeiro Junior, Rafael Dib Possiedi, William A Teeter, Thomas M Scalea, Department of Surgery, R Adams Cowley Shock Trauma Center, School of Medicine, University of Maryland, Baltimore, MD 21201, United States
Marcelo Augusto Fontenelle Ribeiro Junior, Department of Surgery, Pontifical Catholic Uni
Husna Irfan Thalib, General Medicine Practice Program, Batterjee Medical College, Jeddah 21442, Makkah al Mukarramah, Saudi Arabia
Lucas Fontenelle Vieira, Department of Surgery, Florida Atlantic University Charles E Schmidt College of Medicine, Boca Raton, FL 33431, United States
William A Teeter, PRIME-AI Lab, National Study Center for Trauma & Emergency Medical Systems, Baltimore, MD 21201, United States
Co-first authors: Marcelo Augusto Fontenelle Ribeiro Junior and Rafael Dib Possiedi.
Author contributions: Ribeiro Junior MAF and Dib Possiedi R contributed to concepts, design and definition of intellectual content, they served as guarantors of the work and are co-first authors who contributed equally to this study; Ribeiro Junior MAF, Dib Possiedi R, Thalib HI, and Fontenelle Vieira L contributed to literature research, data acquisition and data analysis; Ribeiro Junior MAF, Dib Possiedi R, Thalib HI, Fontenelle Vieira L, Teeter WA, and Scalea TM contributed to manuscript preparation and manuscript review; Ribeiro Junior MAF, Dib Possiedi R, Teeter WA, and Scalea TM contributed to manuscript editing.
AI contribution statement: No part of the manuscript was generated by AI. All content, including the Abstract, Introduction, Materials and Methods, Results, Discussion, and Conclusion, was written by the authors. ChatGPT was used solely for language polishing to improve grammar and fluency. It was not used for data analysis or content generation. No AI tool was involved in the study design, data analysis, or interpretation of results. No images in the manuscript were generated by AI.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Marcelo Augusto Fontenelle Ribeiro Junior, MD, PhD, Chief Physician, Director, FACS, Professor, Senior Researcher, Department of Surgery, R Adams Cowley Shock Trauma Center, School of Medicine, University of Maryland, 22 South Greene Street, Baltimore, MD 21201, United States. mrfibeiro@som.umaryland.edu
Received: December 10, 2025
Revised: February 18, 2026
Accepted: April 1, 2026
Published online: September 9, 2026
Processing time: 254 Days and 15.9 Hours
Revised: February 18, 2026
Accepted: April 1, 2026
Published online: September 9, 2026
Processing time: 254 Days and 15.9 Hours
Core Tip
Core Tip: Evidence on the use of molecular adsorbent recirculating system in trauma-induced liver failure remains extremely limited, and trauma patients are frequently included within broader liver failure cohorts without separate reporting. This scoping review identified only 11 trauma cases that have been clearly documented worldwide, precluding any reliable assessment of survival benefit or safety in this specific setting. Although biochemical improvements are frequent, the true clinical impact of molecular adsorbent recirculating system in trauma cannot be determined without trauma-focused studies using standardized protocols and clearly defined outcomes.