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World J Crit Care Med. Jun 9, 2026; 15(2): 118803
Published online Jun 9, 2026. doi: 10.5492/wjccm.v15.i2.118803
Published online Jun 9, 2026. doi: 10.5492/wjccm.v15.i2.118803
Outcomes of acute kidney injury in critically ill adults with tropical acute febrile illness: Prospective observational study
Sankalp Ranjan, Srishti Jain, Puneet Panwar, Ashish Jain, Ravi Jain, Department of Critical Care Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur 302022, Rajasthan, India
Co-first authors: Sankalp Ranjan and Srishti Jain.
Author contributions: Ranjan S, Jain A, and Jain R conceptualize the study, analysed the data, reviewed, edited the initial manuscript and prepared and reviewed final manuscript; Ranjan S, Jain S, and Panwar P did the data harvesting, curation, investigation; Ranjan S and Jain R wrote the initial manuscript and all the authors provide critical input in final review and preparation of the manuscript. Ranjan S and Jain S contributed equally to this work as co-first authors.
Institutional review board statement: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Ethics Committee of Mahatma Gandhi Medical College and Hospital (Approval No. MGMC&H/IEC/JPR/2024/4127).
Informed consent statement: Written informed consent was obtained from all participants or their legally authorized representatives prior to enrolment in the study.
Conflict-of-interest statement: The authors declare no conflicts of interest pertinent to this project.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The technical appendix, statistical code, and de-identified dataset will be made available from the corresponding author upon reasonable request, subject to approval by the institutional authorities.
Corresponding author: Ravi Jain, MD, Associate Professor, Department of Critical Care Medicine, Mahatma Gandhi Medical College and Hospital, Sitapura, Jaipur 302022, Rajasthan, India. ravijainstar@gmail.com
Received: January 13, 2026
Revised: January 29, 2026
Accepted: February 24, 2026
Published online: June 9, 2026
Processing time: 129 Days and 18.6 Hours
Revised: January 29, 2026
Accepted: February 24, 2026
Published online: June 9, 2026
Processing time: 129 Days and 18.6 Hours
Core Tip
Core Tip: Acute kidney injury (AKI) with tropical acute febrile illness is associated with significant morbidity and low mortality. Early hypoxemia, higher illness severity scores, and the requirement for dialysis independently predict adverse outcomes. This study highlights the need for early risk stratification in this patient subgroup beyond creatinine-based AKI staging.