Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Crit Care Med. Jun 9, 2026; 15(2): 115389
Published online Jun 9, 2026. doi: 10.5492/wjccm.v15.i2.115389
Published online Jun 9, 2026. doi: 10.5492/wjccm.v15.i2.115389
Impact of magnesium on the clearance of lactate in critically sick patients with sepsis: Randomized clinical trial
Chakkaravarthe Anbarasan, Nikhil Kothari, Tanvi M Meshram, Kamlesh Kumari, Shilpa Goyal, Pradeep K Bhatia, Department of Anesthesia and Critical Care, All India Institute of Medical Sciences, Jodhpur 342005, Rājasthān, India
Ankur Sharma, Department of Trauma and Emergency (Anaesthesiology and Critical Care), All India Institute of Medical Sciences, Jodhpur 342008, Rājasthān, India
Author contributions: Anbarasan C prepared the original draft; Sharma A conceptualized and reviewed the draft; Kothari N, Meshram TM, Goyal S, Kumari K, and Bhatia PK reviewed and edited the draft. All authors have read and approved the final manuscript.
Institutional review board statement: Institutional Ethics Committee of AIIMS (All India Institute of Medical Sciences), Jodhpur, Rajasthan, India approval was taken for this trial (approval No. AIIMS/IEC/2022/4177).
Clinical trial registration statement: The study was registered with Clinical Trial Registry - India (No. CTRI/2022/11/047031).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The dataset will be available from the corresponding author on request.
Corresponding author: Ankur Sharma, MD, Additional Professor, Department of Trauma and Emergency (Anaesthesiology and Critical Care), All India Institute of Medical Sciences, Basni Industrial Area, Jodhpur 342008, Rājasthān, India. ankuranaesthesia@gmail.com
Received: October 17, 2025
Revised: December 13, 2025
Accepted: February 14, 2026
Published online: June 9, 2026
Processing time: 217 Days and 23.6 Hours
Revised: December 13, 2025
Accepted: February 14, 2026
Published online: June 9, 2026
Processing time: 217 Days and 23.6 Hours
Core Tip
Core Tip: Early lactate clearance is a key therapeutic target and prognostic marker in sepsis. In this randomized clinical trial, magnesium supplementation significantly accelerated lactate clearance in critically ill patients with sepsis and was associated with reduced vasopressor requirements, shorter intensive care unit stay, and decreased overall hospital stay. Although the magnesium group demonstrated a numerically lower 28-day mortality, this difference did not reach statistical significance.