Nguyen TT, Ngo PTM, Vo LT. Predicting the risk of mortality in children with dengue-induced hepatitis admitted to the paediatric intensive care unit. World J Crit Care Med 2024; 13(4): 98862 [PMID: 39655306 DOI: 10.5492/wjccm.v13.i4.98862]
Corresponding Author of This Article
Thanh Tat Nguyen, MD, PhD, Academic Research, Senior Researcher, Department of Tuberculosis, Woolcock Institute of Medical Research, Pham Ngoc Thach Street, Ho Chi Minh 700000, Viet Nam. thanhhonor@gmail.com
Research Domain of This Article
Critical Care Medicine
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Nguyen TT, Ngo PTM, Vo LT. Predicting the risk of mortality in children with dengue-induced hepatitis admitted to the paediatric intensive care unit. World J Crit Care Med 2024; 13(4): 98862 [PMID: 39655306 DOI: 10.5492/wjccm.v13.i4.98862]
World J Crit Care Med. Dec 9, 2024; 13(4): 98862 Published online Dec 9, 2024. doi: 10.5492/wjccm.v13.i4.98862
Predicting the risk of mortality in children with dengue-induced hepatitis admitted to the paediatric intensive care unit
Thanh Tat Nguyen, Phuong Thi-Mai Ngo, Luan Thanh Vo
Thanh Tat Nguyen, Department of Tuberculosis, Woolcock Institute of Medical Research, Ho Chi Minh 700000, Viet Nam
Thanh Tat Nguyen, Phuong Thi-Mai Ngo, Luan Thanh Vo, Department of Infectious Diseases, The Children’s Hospital 2, Ho Chi Minh 700000, Viet Nam
Co-corresponding authors: Thanh Tat Nguyen and Luan Thanh Vo.
Author contributions: Nguyen TT was responsible for formal analysis, methodology, and funding acquisition; Nguyen TT and Ngo TMP were responsible for writing original draft; Nguyen TT and Vo TL were responsible for conceptualization; Nguyen TT, Vo TL, and Ngo TMP were responsible for data curation, investigation, and critical revision of the final manuscript; all of the authors read and approved the final version of the manuscript to be published.
Institutional review board statement: This sub-study stemmed from the main research, which was approved by the Scientific Committee and Institutional Review Board of the Children’s Hospital 2, Ho Chi Minh City, Vietnam (approval No. 391/QD-BVND2, March 22, 2022).
Informed consent statement: We used a secondary dataset from primary research, which was considered to cause less than minimal risk to participants. Therefore, the need for ethical approval was waived. This study was performed in accordance with the principles of Good Clinical Practice and ethical guidelines of the Declaration of Helsinki.
Conflict-of-interest statement: All authors declare that there is no conflict of interest.
Data sharing statement: The original contributions of this study are included in the article and supplementary material. Further requests can be directed to the corresponding authors.
Corresponding author: Thanh Tat Nguyen, MD, PhD, Academic Research, Senior Researcher, Department of Tuberculosis, Woolcock Institute of Medical Research, Pham Ngoc Thach Street, Ho Chi Minh 700000, Viet Nam. thanhhonor@gmail.com
Received: July 8, 2024 Revised: September 26, 2024 Accepted: October 20, 2024 Published online: December 9, 2024 Processing time: 115 Days and 7.9 Hours
Core Tip
Core Tip: The prevalence of dengue-associated acute liver failure in children with dengue-induced severe hepatitis (DISH) was 18.3%. The in-hospital mortality rate was approximately 8.5% among DISH patients developing acute liver failure. Hepatic biomarkers, including international normalized ratio (INR) (≥ 2.11) and total serum bilirubin (≥ 1.7 mg/dL), showed high predictive values for mortality. The significant predictors of mortality in children with DISH were decreased level of consciousness (pain and unresponsive levels on the Alert, Verbal, Pain, Unresponsive scale), high vasoactive-inotropic score (> 30), elevated blood lactate and INR levels during the first 24 hours of pediatric intensive care unit admission, and rising serum bilirubin during the first 72 hours of admission.
