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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Jun 9, 2023; 12(3): 139-152
Published online Jun 9, 2023. doi: 10.5492/wjccm.v12.i3.139
Published online Jun 9, 2023. doi: 10.5492/wjccm.v12.i3.139
Sepsis-induced mitochondrial dysfunction: A narrative review
Wagner Nedel, Intensive Care Unit, Grupo Hospitalar Conceição, Porto Alegre 91350200, Brazil
Wagner Nedel, Luis Valmor Cruz Portela, Laboratory of Neurotrauma and Biomarkers, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Brazil
Wagner Nedel, Brazilian Research in Intensive Care Network-BRICNet, São Paulo 04039-002, Brazil
Caroline Deutschendorf, Infection Control Committee, Hospital de Clínicas de Porto Alegre, Porto Alegre 90410-000, Brazil
Author contributions: Nedel W contributed to research, wrote the manuscript, reviewed the final version, and made the graphs and figures; Deutschendorf C contributed to write the manuscript and reviewed the final version; Portela LVC contributed to write the manuscript, reviewed the final version.
Supported by the Fundação de Amparo a Pesquisa do Estado do Rio Grande do Sul , No. 1010267 .
Conflict-of-interest statement: The authors state that there was no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wagner Nedel, MD, MHSc, Assistant Professor, Medical Assistant, Intensive Care Unit, Grupo Hospitalar Conceição, Francisco Trein 596, Segundo Andar, Porto Alegre 91350200, Brazil. wagnernedel@gmail.com
Received: January 20, 2023
Peer-review started: January 20, 2023
First decision: February 20, 2023
Revised: March 8, 2023
Accepted: April 14, 2023
Article in press: April 14, 2023
Published online: June 9, 2023
Processing time: 138 Days and 17.9 Hours
Peer-review started: January 20, 2023
First decision: February 20, 2023
Revised: March 8, 2023
Accepted: April 14, 2023
Article in press: April 14, 2023
Published online: June 9, 2023
Processing time: 138 Days and 17.9 Hours
Core Tip
Core Tip: The evaluation of mitochondrial metabolism is a promising tool for the evaluation and management of critically ill patients, particularly those with sepsis. In this article, we explore the pathophysiological aspects, main methods of measurement, and main studies in this field.