Meta-Analysis
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Nov 9, 2021; 10(6): 390-400
Published online Nov 9, 2021. doi: 10.5492/wjccm.v10.i6.390
Recovery after acute kidney injury requiring kidney replacement therapy in patients with left ventricular assist device: A meta-analysis
Karthik Kovvuru, Swetha R Kanduri, Charat Thongprayoon, Tarun Bathini, Saraschandra Vallabhajosyula, Wisit Kaewput, Michael A Mao, Wisit Cheungpasitporn, Kianoush B Kashani
Karthik Kovvuru, Swetha R Kanduri, Division of Nephrology, Department of Medicine, Ochsner Clinic Foundation, New Orleans, LA 70121, United States
Charat Thongprayoon, Wisit Cheungpasitporn, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, United States
Tarun Bathini, Department of Internal Medicine, University of Arizona, Tucson, AZ 85721, United States
Saraschandra Vallabhajosyula, Section of Cardiovascular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27101, United States
Wisit Kaewput, Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand
Michael A Mao, Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL 32224, United States
Kianoush B Kashani, Department of Medicine, Division of Nephrology and Hypertension, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, United States
Author contributions: Kovvuru K, Kanduri S, Thongprayoon C and Cheungpasitporn W acquired data and designed the research; Bathini T, Vallabhajosyula S interpreted the data and performed research; Kanduri S, Kaewput W, Mao MA analyzed the data and drafted the article; Kovvuru K, Cheungpasitporn W, Kashani KB revised the article and contributed to final approval.
Conflict-of-interest statement: The authors declared no potential conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wisit Cheungpasitporn, FACP, Associate Professor, Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, United States. wcheungpasitporn@gmail.com
Received: April 3, 2021
Peer-review started: April 3, 2021
First decision: June 5, 2021
Revised: June 7, 2021
Accepted: October 11, 2021
Article in press: October 11, 2021
Published online: November 9, 2021
Processing time: 215 Days and 8.4 Hours
Core Tip

Core Tip: Left ventricular assist devices (LVAD) are mechanical support tools that augment cardiac output and improve kidney perfusion. Acute Kidney Injury (AKI) is a common complication after LVAD implantation. High short- and long-term mortality is associated with severe AKI requiring Kidney replacement therapy (KRT) in LVAD patients compared with those without KRT. While kidney function recovery is associated with better outcomes, the recovery rate is unclear among LVAD patients with severe AKI requiring KRT. To investigate this further, we conducted the current systematic review and meta-analysis evaluating kidney recovery rate after AKI-KRT among LVAD patients. We report that the pooled estimated AKI recovery rate among patients with severe AKI-KRT was 50.5% (95%CI: 34.0%-67.0%) at 12 mo follow up.