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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Sep 9, 2021; 10(5): 260-277
Published online Sep 9, 2021. doi: 10.5492/wjccm.v10.i5.260
Published online Sep 9, 2021. doi: 10.5492/wjccm.v10.i5.260
Neutrophil kinetics and function after major trauma: A systematic review
Liam DB Finlay, Melbourne Medical School, University of Melbourne, Melbourne 3052, Victoria, Australia
Andrew Conway Morris, Department of Medicine, University of Cambridge, Cambridge 01223, United Kingdom
Adam M Deane, Alexander JT Wood, Centre for Integrated Critical Care, University of Melbourne, Parkville 3052, Victoria, Australia
Adam M Deane, Alexander JT Wood, Intensive Care Unit, Royal Melbourne Hospital, Parkville 3052, Victoria, Australia
Author contributions: Finlay LDB and Wood AJT screened and analysed included studies and wrote the manuscript; Conway Morris A and Deane AM assisted with critical review and editing of the manuscript; all authors have read and approved the final manuscript.
Supported by the Clinical Research Career Development Fellowship from the Wellcome Trust , No. WT 205214/Z/16/Z ; the MRC Clinician Scientist Fellowship , No. MR/V006118/1 ; and the Career Development Fellowship from the National Health and Medical Research Council of Australia , No. APP1141870 .
Conflict-of-interest statement: There are no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The guidelines of the PRISMA 2009 Statement have been adopted.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alexander JT Wood, MBBS, PhD, Doctor, Intensive Care Unit, Royal Melbourne Hospital, Intensive Care Unit Offices Level 5, B Block Royal Melbourne Hospital 300 Grattan Street, Parkville 3052, Victoria, Australia. alex.wood1@unimelb.edu.au
Received: February 21, 2021
Peer-review started: February 21, 2021
First decision: May 13, 2021
Revised: June 22, 2021
Accepted: July 27, 2021
Article in press: July 27, 2021
Published online: September 9, 2021
Processing time: 200 Days and 3.3 Hours
Peer-review started: February 21, 2021
First decision: May 13, 2021
Revised: June 22, 2021
Accepted: July 27, 2021
Article in press: July 27, 2021
Published online: September 9, 2021
Processing time: 200 Days and 3.3 Hours
Core Tip
Core Tip: Major trauma results in complex immune dysfunction, with dysregulated pro- and anti-inflammatory processes presenting as clinical syndromes such as acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MODS). This review examines the role of neutrophils in immune dysfunction following major trauma requiring admission to the intensive care unit, with a focus on the kinetics of the neutrophil immunophenotype and how this correlates with clinical outcomes. This review also proposes new hypotheses as to the mechanisms of complications of immune dysfunction, including ARDS and MODS.