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Takahashi H, Okada Y, Hong D, Quah D, Leong BS, Ng YY, Shahidah N, Goh GS, Yazid M, Suzuki K, Neumar RW, Ong ME, Singapore PAROS Investigators. Association between time taken to start Dispatch Assisted-Bystander Cardiopulmonary Resuscitation (DA-CPR) and outcomes for Out-of-Hospital Cardiac Arrest (OHCA). Resuscitation 2025:110651. [PMID: 40409669 DOI: 10.1016/j.resuscitation.2025.110651] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/02/2025] [Revised: 04/28/2025] [Accepted: 05/07/2025] [Indexed: 05/25/2025]
Abstract
BACKGROUND We aimed to investigate the association between the time taken to start dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) and survival outcomes for OHCA. METHODS This was a retrospective analysis using the Singapore Pan-Asian Resuscitation Outcomes Study data between 2012 and 2021. We included all adult, witnessed, non-traumatic OHCA patients who received DA-CPR. The exposure of interest was time interval from emergency call to start of DA-CPR. Patients were divided into three groups based on previous studies. The outcome was defined as survival to 30-days with favorable neurological outcomes. Multivariable logistic regression analysis was performed. Restricted cubic spline curves were used to explore non-linear relationships. RESULTS 3,861 OHCA patients were included in this analysis. Patients were grouped as follows: short (0-179 seconds), medium (180-239 seconds), and long (≥240 seconds) to start DA-CPR. Adjusted odds ratios [95% CI] for survival to 30-days with favorable neurological outcomes were: medium 0.82 [0.52-1.28], long 0.63 [0.40-0.98]. The restricted cubic spline curve showed a monotonic decrease in the odds ratio for survival to 30-days with favorable neurological outcomes. CONCLUSIONS This study found that among non-traumatic, witnessed OHCA patients who received DA-CPR, a shorter time to start DA-CPR was associated with better 30-day survival with favorable neurological outcomes.
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Affiliation(s)
- Haruka Takahashi
- Health Services & Systems Research, Duke-NUS Medical School, Singapore; The Graduate School of Medical and Health Science, Nippon Sport Science University, Japan
| | - Yohei Okada
- Health Services & Systems Research, Duke-NUS Medical School, Singapore; Department of Preventive Services, Graduate School of Medicine, Kyoto University, Japan.
| | - Dehan Hong
- Emergency Medical Services Department, Singapore Civil Defense Force, Singapore
| | - Dennis Quah
- Operations Department, Singapore Civil Defence Force, Singapore
| | - Benjamin Sh Leong
- Emergency Medicine Department, National University Hospital, Singapore
| | - Yih Yng Ng
- Department of Preventive and Population Medicine, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
| | - Nur Shahidah
- Department of Emergency Medicine, Singapore General Hospital, Singapore
| | - Geraldine Sy Goh
- Unit for Pre-hospital Emergency Care, Singapore General Hospital, Singapore
| | - Muhammad Yazid
- Unit for Pre-hospital Emergency Care, Singapore General Hospital, Singapore
| | - Kensuke Suzuki
- The Graduate School of Medical and Health Science, Nippon Sport Science University, Japan
| | - Robert W Neumar
- Department of Emergency Medicine, University of Michigan, USA; Department of Molecular and Integrative Physiology, University of Michigan, USA; The Max Harry Weil Institute for Critical Care Research and Innovation, University of Michigan, USA
| | - Marcus Eh Ong
- Health Services & Systems Research, Duke-NUS Medical School, Singapore; Department of Emergency Medicine, Singapore General Hospital, Singapore
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Castillo J, González-Marrón A, Llongueras A, Camós L, Montané M, Rodríguez-Higueras E. Competencies in Basic Life Support after a Course with or without Rescue Ventilation: Historical Cohort Study. Healthcare (Basel) 2022; 10:2564. [PMID: 36554087 PMCID: PMC9779074 DOI: 10.3390/healthcare10122564] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/16/2022] [Revised: 12/09/2022] [Accepted: 12/14/2022] [Indexed: 12/24/2022] Open
Abstract
BACKGROUND Simplifying the international guidelines to improve skills after training and their retention over time has been one of the top priorities in recent years. The objective of our study was to compare the results of the practical skills learned during training in basic life support with and without pulmonary ventilation. METHODS This was a comparative study of historical cohorts consisting of undergraduate students in health sciences. In one cohort, rescue breathing was performed, and in the other, it was not. The same data collection instruments were used for both cohorts: a test type examination of knowledge, data from a smart mannequin and an instructor observation grid. The means of knowledge and practical skills scores collected by the mannequin were compared using independent sample t-tests. RESULTS 497 students were recruited without significant differences between the two cohorts. The mean scores for knowledge and skills determined by the instructor and the mannequin were statistically higher in the cohort that did not perform rescue breathing. CONCLUSION Students who participated in basic life support training that did not include rescue breathing scored better than those who participated in training that included this skill. Training with only compressions simplifies the guidelines and increases learning and content retention.
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Affiliation(s)
- Jordi Castillo
- Universitat Internacional de Catalunya (UIC), Sant Cugat del Vallès, 08195 Barcelona, Spain
| | - Adrián González-Marrón
- Universitat Internacional de Catalunya (UIC), Sant Cugat del Vallès, 08195 Barcelona, Spain
| | | | - Laia Camós
- Sistema Emergències Mèdiques (SEM), 08908 Barcelona, Spain
| | - Mireia Montané
- Sistema Emergències Mèdiques (SEM), 08908 Barcelona, Spain
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Takano K, Asai H, Fukushima H. Effect of Coaching with Repetitive Verbal Encouragements on Dispatch-Assisted Cardiopulmonary Resuscitation: A Randomized Simulation Study. J Emerg Med 2022; 63:240-246. [PMID: 35871989 DOI: 10.1016/j.jemermed.2022.05.010] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/23/2021] [Revised: 04/13/2022] [Accepted: 05/09/2022] [Indexed: 11/30/2022]
Abstract
BACKGROUND Current guidelines emphasize the assistance of the emergency dispatcher in bystander cardiopulmonary resusitation (CPR). Its quality, however, has varied across cases. OBJECTIVE To determine the effect of repetitive coaching by dispatchers using verbal encouragement on the quality of lay-rescuer CPR. METHODS We conducted a dispatch-assisted CPR (DACPR) simulation study. Participants with no CPR training within the previous year were assigned randomly to 1 of 2 DACPR simulations. One was the No Coaching Group: callers were told to perform CPR and the dispatcher periodically confirmed that the caller was performing CPR. The second group was the Coaching Group: the dispatcher repetitively coached, encouraged, and counted aloud using a metronome. Participants performed CPR for 2 min under instruction from the study dispatcher. Parameters including chest compression depth, rate, and chest compression fraction were recorded by video camera and CPR manikin. RESULTS Forty-nine participants 20 to 50 years of age were recruited, and 48 completed the simulation (Coaching Group, n = 27; No Coaching Group, n = 21). The chest compression fraction was higher in the Coaching Group (99.4% vs. 93.0%, p = 0.005) and no participants interrupted chest compression more than 10 s in this group. When comparing the average depth of each 30-s period in each group, the depth increased over time in the Coaching Group (40.9 mm, 43.9 mm, 44.1 mm, and 42.8 mm), while it slightly decreased in the No Coaching Group (40.6 mm, 40.1 mm, 39.4 mm, and 39.8 mm). CONCLUSIONS Repetitive verbal encouragements augmented chest compression depth with less-hands off time. Continuous coaching by dispatchers can optimize lay-rescuer CPR. © 2022 Elsevier Inc.
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Affiliation(s)
- Keisuke Takano
- Department of Emergency and Critical Care Medicine, Nara Medical University, Shijo-cho, Nara, Japan
| | - Hideki Asai
- Department of Emergency and Critical Care Medicine, Nara Medical University, Shijo-cho, Nara, Japan
| | - Hidetada Fukushima
- Department of Emergency and Critical Care Medicine, Nara Medical University, Shijo-cho, Nara, Japan
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Richards CT, McCarthy DM, Markul E, Rottman DR, Lindeman P, Prabhakaran S, Klabjan D, Holl JL, Cameron KA. A mixed methods analysis of caller-emergency medical dispatcher communication during 9-1-1 calls for out-of-hospital cardiac arrest. PATIENT EDUCATION AND COUNSELING 2022; 105:2130-2136. [PMID: 35304072 DOI: 10.1016/j.pec.2022.03.004] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/15/2021] [Revised: 02/15/2022] [Accepted: 03/04/2022] [Indexed: 06/14/2023]
Abstract
OBJECTIVE Recognition of out-of-hospital cardiac arrest (OHCA) during 9-1-1 calls is critically important, but little is known about how laypersons and emergency medical dispatchers (EMDs) communicate. We sought to describe 9-1-1 calls for OHCA. METHODS We performed a mixed-methods, retrospective analysis of 9-1-1 calls for OHCA victims in a large urban emergency medical services (EMS) system using a random sampling of cases containing the term "cardiopulmonary resuscitation" (CPR) in the EMS electronic report. A constant comparison qualitative approach with four independent reviewers continued until thematic saturation was achieved. Quantitative analysis employed computational linguistics. Callers' emotional states were rated using the emotional content and cooperation score (ECCS). RESULTS Thematic saturation was achieved after 46 calls. Three "OHCA recognition" themes emerged [ 1) disparate OHCA terms used, 2) OHCA mimics create challenges, 3) EMD questions influence recognition]. Three "CPR facilitation" themes emerged [ 1) directive language may facilitate CPR, 2) specific instructions assist CPR, 3) caller's emotions affect CPR initiation]. Callers were generally "anxious but cooperative." Callers saying "pulse" was associated with OHCA recognition. CONCLUSION Communication characteristics appear to influence OHCA recognition and CPR facilitation. PRACTICE IMPLICATIONS Dispatch protocols that acknowledge characteristics of callers' communication may improve OHCA recognition and CPR facilitation.
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Affiliation(s)
- Christopher T Richards
- Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Emergency Medicine, Northwestern Feinberg School of Medicine, Chicago, IL, USA; Chicago EMS System, Chicago, IL, USA.
| | - Danielle M McCarthy
- Department of Emergency Medicine, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
| | - Eddie Markul
- Chicago EMS System, Chicago, IL, USA; Department of Emergency Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA.
| | | | - Patricia Lindeman
- Department of Emergency Medicine, Northwestern Feinberg School of Medicine, Chicago, IL, USA; Chicago EMS System, Chicago, IL, USA.
| | - Shyam Prabhakaran
- Department of Neurology, The University of Chicago Biological Sciences, Chicago, IL, USA.
| | - Diego Klabjan
- Department of Industrial Engineering and Management Sciences, Northwestern University McCormick School of Engineering, Evanston, IL, USA.
| | - Jane L Holl
- Department of Neurology, The University of Chicago Biological Sciences, Chicago, IL, USA.
| | - Kenzie A Cameron
- Division of General Internal Medicine & Geriatrics, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
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Valeriano A, Van Heer S, de Champlain F, C Brooks S. Crowdsourcing to save lives: A scoping review of bystander alert technologies for out-of-hospital cardiac arrest. Resuscitation 2021; 158:94-121. [PMID: 33188832 DOI: 10.1016/j.resuscitation.2020.10.035] [Citation(s) in RCA: 48] [Impact Index Per Article: 12.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/08/2020] [Revised: 10/08/2020] [Accepted: 10/19/2020] [Indexed: 11/30/2022]
Abstract
AIM Out-of-hospital cardiac arrest (OHCA) constitutes a significant global health burden, with a survival rate of only 10-12%. Mobile phone technologies have been developed that crowdsource citizen volunteers to nearby OHCAs in order to initiate resuscitation prior to ambulance arrival. We performed a scoping review to map the available literature on these crowdsourcing technologies and compared their technical specifications. METHODS A search strategy was developed for five online databases. Two reviewers independently assessed all articles for inclusion and extracted relevant study information. Subsequently, we performed a supplementary internet search and consulted experts to identify all available bystander alert technologies and their specifications. RESULTS We included 65 articles examining bystander alerting technologies from more than 15 countries. We also identified 25 unique technologies, of which 18 were described in the included literature. Technologies were text message-based systems (n = 3) or mobile phone applications (n = 22). Most (21/25) used global positioning systems to direct bystanders to victims and nearby AEDs. Response radii for alerts varied widely from 200 m to 10 km. Some technologies incorporated advanced features such as video-conferencing with ambulance dispatch and detailed alert settings. Not all systems required volunteers to have training in cardiopulmonary resuscitation. Only ten studies assessed impact on clinical outcomes. Key barriers discussed included false positive alerts, legal liability, and potential psychological impact on volunteers. CONCLUSION Our review provides a comprehensive overview of crowdsourcing technologies for bystander intervention in out-of-hospital cardiac arrest. Future work should focus on clinical outcomes and methods of addressing barriers to implementation.
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Affiliation(s)
| | - Shyan Van Heer
- School of Medicine, Queen's University, Kingston, Canada
| | | | - Steven C Brooks
- Department of Emergency Medicine, Queen's University, Kingston, Canada.
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Fukushima H, Bolstad F. Telephone CPR: Current Status, Challenges, and Future Perspectives. Open Access Emerg Med 2020; 12:193-200. [PMID: 32982493 PMCID: PMC7490094 DOI: 10.2147/oaem.s259700] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/24/2020] [Accepted: 08/12/2020] [Indexed: 12/16/2022] Open
Abstract
With each successive update of the cardiopulmonary resuscitation (CPR) guidelines, the role of dispatchers in sudden cardiac arrest (CA) has grown. Dispatchers instruct callers in how to perform CPR until the arrival of emergency medical service (EMS) professionals. This is widely known as telephone CPR (TCPR) or dispatch-assisted CPR (DACPR). Studies have shown the efficacy of TCPR in increasing the survival rate of sudden CA. The TCPR process, however, is challenging and needs to be constantly evaluated and refined in order to improve the survival rate of sudden CA victims throughout the world. In this review article, the current status, challenges, and future perspectives of TCPR are discussed with a view to providing a research foundation from which to launch further studies into the effective role of dispatchers in sudden CA.
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Affiliation(s)
- Hidetada Fukushima
- Department of Emergency and Critical Care Medicine, Nara Medical University, Kashihara City, Nara, Japan
| | - Francesco Bolstad
- Department of Clinical English, Nara Medical University, Kashihara City, Nara, Japan
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The effect of 10-min dispatch-assisted cardiopulmonary resuscitation training: a randomized simulation pilot study. Int J Emerg Med 2020; 13:31. [PMID: 32527221 PMCID: PMC7291724 DOI: 10.1186/s12245-020-00287-9] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/15/2020] [Accepted: 05/26/2020] [Indexed: 11/20/2022] Open
Abstract
Background Immediate bystander cardiopulmonary resuscitation (CPR) is essential for survival from sudden cardiac arrest (CA). Current CPR guidelines recommend that dispatchers assist lay rescuers performing CPR (dispatch-assisted CPR (DACPR)), which can double the frequency of bystander CPR. Laypersons, however, are not familiar with receiving CPR instructions from dispatchers. DACPR training can be beneficial for lay rescuers, but this has not yet been validated. The aim of this study was to determine the effectiveness of simple DACPR training for lay rescuers. Methods We conducted a DACPR simulation pilot study. Participants who were non-health care professionals with no CPR training within 1 year prior to this study were recruited from Nara Medical University Hospital. The participants were randomly assigned to one of the two 90-min adult basic life support (BLS) training course groups: DACPR group (standard adult BLS training plus an additional 10-min DACPR training) or Standard group (standard adult BLS training only). In the DACPR group, participants practiced DACPR through role-playing of a dispatcher and an emergency caller. Six months after the training, all subjects were asked to perform a 2-min CPR simulation under instructions given by off-duty dispatchers. Results Out of the 66 participants, 59 completed the simulation (30 from the DACPR group and 29 from the Standard group). The CPR quality was similar between the two groups. However, the median time interval between call receipt and the first dispatch-assisted compression was faster in the DACPR group (108 s vs 129 s, p = 0.042). Conclusions This brief DACPR training in addition to standard CPR training can result in a modest improvement in the time to initiate CPR. Future studies are now required to examine the effect of DACPR training on survival of sudden CA.
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8
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Hasegawa T, Okane R, Ichikawa Y, Inukai S, Saito S. Effect of chest compression with kneeling on the bed in clinical situations. Jpn J Nurs Sci 2020; 17:e12314. [PMID: 31957258 PMCID: PMC7189814 DOI: 10.1111/jjns.12314] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/03/2019] [Revised: 09/08/2019] [Accepted: 11/18/2019] [Indexed: 11/29/2022]
Abstract
Aim Cardiopulmonary resuscitation is vital for survival after cardiac arrest, and chest compressions are an important aspect of this. When performing chest compression in a hospital setting, the rescuer often has to kneel on the bed to overcome inconvenient differences in height between the rescuer and the bed. However, as yet no study has evaluated the quality of chest compressions in this position. The aim of this study was to examine the impact on the quality of chest compressions while kneeling on the bed. Methods Fifteen female students performed 2‐min chest compressions on a manikin placed on the floor and a bed. Measurement parameters included compression depth, heart rate, integrated electromyogram, and a visual analog scale. The parameters were measured every 30 s and were statistically compared between the conditions. Results Compression depth at 30, 60, 90, and 120 s differed significantly between the conditions. Heart rate values at 150 and 210 s of recovery significantly differed between the conditions. Integrated electromyogram values for the trapezius, rectus femoris, and biceps femoris differed between the floor and bed conditions during 2‐min chest compressions, whereas the external oblique muscle significantly differed at 60 and 120 s. Visual analog scales for fatigue, effectiveness, and stability significantly differed between the conditions. Conclusion Kneeling on the bed does not enable grounding of the toe, causing the upper body to be unstable and limiting generation of the power required for chest compression. Our results suggest that rotation every minute is necessary to maintain effective cardiopulmonary resuscitation while kneeling on the bed.
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Affiliation(s)
| | - Ritsu Okane
- Mie Prefectural College of Nursing, Tsu, Japan
| | | | | | - Shin Saito
- Mie Prefectural College of Nursing, Tsu, Japan
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Ko SY, Shin SD, Ro YS, Song KJ, Hong KJ, Park JH, Lee SC. Effect of detection time interval for out-of-hospital cardiac arrest on outcomes in dispatcher-assisted cardiopulmonary resuscitation: A nationwide observational study. Resuscitation 2018; 129:61-69. [DOI: 10.1016/j.resuscitation.2018.06.002] [Citation(s) in RCA: 15] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/03/2018] [Revised: 05/05/2018] [Accepted: 06/01/2018] [Indexed: 11/28/2022]
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Fukushima H, Panczyk M, Hu C, Dameff C, Chikani V, Vadeboncoeur T, Spaite DW, Bobrow BJ. Description of Abnormal Breathing Is Associated With Improved Outcomes and Delayed Telephone Cardiopulmonary Resuscitation Instructions. J Am Heart Assoc 2017; 6:JAHA.116.005058. [PMID: 28851728 PMCID: PMC5634247 DOI: 10.1161/jaha.116.005058] [Citation(s) in RCA: 18] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/17/2022]
Abstract
Background Emergency 9‐1‐1 callers use a wide range of terms to describe abnormal breathing in persons with out‐of‐hospital cardiac arrest (OHCA). These breathing descriptors can obstruct the telephone cardiopulmonary resuscitation (CPR) process. Methods and Results We conducted an observational study of emergency call audio recordings linked to confirmed OHCAs in a statewide Utstein‐style database. Breathing descriptors fell into 1 of 8 groups (eg, gasping, snoring). We divided the study population into groups with and without descriptors for abnormal breathing to investigate the impact of these descriptors on patient outcomes and telephone CPR process. Callers used descriptors in 459 of 2411 cases (19.0%) between October 1, 2010, and December 31, 2014. Survival outcome was better when the caller used a breathing descriptor (19.6% versus 8.8%, P<0.0001), with an odds ratio of 1.63 (95% confidence interval, 1.17–2.25). After exclusions, 379 of 459 cases were eligible for process analysis. When callers described abnormal breathing, the rates of telecommunicator OHCA recognition, CPR instruction, and telephone CPR were lower than when callers did not use a breathing descriptor (79.7% versus 93.0%, P<0.0001; 65.4% versus 72.5%, P=0.0078; and 60.2% versus 66.9%, P=0.0123, respectively). The time interval between call receipt and OHCA recognition was longer when the caller used a breathing descriptor (118.5 versus 73.5 seconds, P<0.0001). Conclusions Descriptors of abnormal breathing are associated with improved outcomes but also with delays in the identification of OHCA. Familiarizing telecommunicators with these descriptors may improve the telephone CPR process including OHCA recognition for patients with increased probability of survival.
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Affiliation(s)
- Hidetada Fukushima
- Arizona Department of Health Services, Phoenix, AZ .,Department of Emergency and Critical Care Medicine, Nara Medical University, Nara, Japan.,Arizona Emergency Medicine Research Center, University of Arizona College of Medicine, Phoenix, AZ
| | | | - Chengcheng Hu
- Department or Epidemiology and Biostatistics, University of Arizona Mel and Enid Zuckerman College of Public Health, Tucson, AZ
| | - Christian Dameff
- Arizona Emergency Medicine Research Center, University of Arizona College of Medicine, Phoenix, AZ
| | | | | | - Daniel W Spaite
- Arizona Emergency Medicine Research Center, University of Arizona College of Medicine, Phoenix, AZ
| | - Bentley J Bobrow
- Arizona Department of Health Services, Phoenix, AZ.,Arizona Emergency Medicine Research Center, University of Arizona College of Medicine, Phoenix, AZ.,Department of Emergency Medicine, University of Arizona College of Medicine, Phoenix, AZ
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Meischke H, Painter IS, Stangenes SR, Weaver MR, Fahrenbruch CE, Rea T, Turner AM. Simulation training to improve 9-1-1 dispatcher identification of cardiac arrest: A randomized controlled trial. Resuscitation 2017; 119:21-26. [PMID: 28760696 DOI: 10.1016/j.resuscitation.2017.07.025] [Citation(s) in RCA: 19] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/17/2017] [Revised: 07/03/2017] [Accepted: 07/21/2017] [Indexed: 11/26/2022]
Abstract
BACKGROUND The objective of this study was to test the effectiveness of simulation training, using actors to make mock calls, on improving Emergency Medical Dispatchers' (EMDs) ability to recognize the need for, and reduce the time to, telephone-assisted CPR (T-CPR) in simulated and real cardiac arrest 9-1-1 calls. METHODS We conducted a parallel prospective randomized controlled trial with n=157 EMDs from thirteen 9-1-1 call centers. Study participants were randomized within each center to intervention (i.e., completing 4 simulation training sessions over 12-months) or control (status quo). After the intervention period, performance on 9 call processing skills and 2 time-intervals were measured in 2 simulation assessment calls for both arms. Six of the 13 call centers provided recordings of real cardiac arrest calls taken by study participants during the study period. RESULTS Of the N=128 EMDs who completed the simulation assessment, intervention participants (n=66) performed significantly better on 6 of 9 call processing skills and started T-CPR 23s faster (73 vs 91s respectively, p<0.001) compared to participants in the control arm (n=62). In real cardiac arrest calls, EMDs who completed 3 or 4 training sessions were more likely to recognize the need for T-CPR for more challenging cardiac arrest calls than EMDs who completed fewer than 3, including controls who completed no training (68% vs 53%, p=0.018). CONCLUSIONS Simulation training improves call processing skills and reduces time to T-CPR in simulated call scenarios, and may improve the recognition of the need for T-CPR in more challenging real-life cardiac arrest calls. CLINICAL TRIAL REGISTRATION http://www.clinicaltrials.gov Trial # NCT01972087.
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Affiliation(s)
- Hendrika Meischke
- Department of Health Services, University of Washington, Seattle, WA, United States
| | - Ian S Painter
- Department of Health Services, University of Washington, Seattle, WA, United States
| | - Scott R Stangenes
- Department of Health Services, University of Washington, Seattle, WA, United States.
| | - Marcia R Weaver
- Department of Health Services and Department of Global Health, University of Washington, Seattle WA, United States
| | - Carol E Fahrenbruch
- Public Health Seattle-King County, Emergency Medical Services Division, Seattle, WA, United States
| | - Tom Rea
- Department of Medicine, University of Washington, Seattle, WA, United States
| | - Anne M Turner
- Department of Health Services and Department of Biomedical Informatics University of Washington, Seattle, WA, United States
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12
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Wu Z, Panczyk M, Spaite DW, Hu C, Fukushima H, Langlais B, Sutter J, Bobrow BJ. Telephone cardiopulmonary resuscitation is independently associated with improved survival and improved functional outcome after out-of-hospital cardiac arrest. Resuscitation 2017; 122:135-140. [PMID: 28754526 DOI: 10.1016/j.resuscitation.2017.07.016] [Citation(s) in RCA: 67] [Impact Index Per Article: 8.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/21/2017] [Revised: 07/18/2017] [Accepted: 07/20/2017] [Indexed: 11/17/2022]
Abstract
AIM OF STUDY This study aims to quantify the relative impact of Dispatcher-Initiated Telephone cardiopulmonary resuscitation (TCPR) on survival and survival with favorable functional outcome after out-of-hospital cardiac arrest (OHCA) in a population of patients served by multiple emergency dispatch centers and more than 130 emergency medical services (EMS) agencies. METHODS We conducted a retrospective, observational study of EMS-treated adult (≥18 years) patients with OHCA of presumed cardiac origin in Arizona, between January 1, 2011, and December 31, 2014. We compared survival and functional outcome among three distinct groups of OHCA patients: those who received no CPR before EMS arrival (no CPR group); those who received BCPR before EMS arrival and prior to or without telephone CPR instructions (BCPR group); and those who received TCPR (TCPR group). RESULTS In this study, 2310 of 4391 patients met the study criteria (median age, 62 years; IQR 50, 74; 1540 male). 32.8% received no CPR, 23.8% received Bystander-Initiated CPR and 43.4% received TCPR. Overall survival was 11.5%. Using no CPR as the reference group, the multivariate adjusted odds ratio for survival at hospital discharge was 1.51 (95% confidence interval [CI], 1.04, 2.18) for BCPR and 1.64 (95% CI, 1.16, 2.30) for TCPR. The multivariate adjusted odds ratio of favorable functional outcome at discharge was 1.58 (95% CI 1.05, 2.39) for BCPR and 1.56 (95% CI, 1.06, 2.31) for TCPR. CONCLUSION TCPR is independently associated with improved survival and improved functional outcome after OHCA.
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Affiliation(s)
- Zhixin Wu
- Department of Emergency and Critical Care Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan City, Guangdong Province, China
| | - Micah Panczyk
- Bureau of EMS & Trauma System, Arizona Department of Health Services, Phoenix, AZ, United States.
| | - Daniel W Spaite
- Arizona Emergency Medicine Research Center, University of Arizona College of Medicine - Phoenix, Phoenix, AZ, United States
| | - Chengcheng Hu
- Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, United States
| | - Hidetada Fukushima
- Department of Emergency and Critical Care Medicine, Nara Medical University, Kashihara, Nara, Japan
| | - Blake Langlais
- Bureau of EMS & Trauma System, Arizona Department of Health Services, Phoenix, AZ, United States
| | - John Sutter
- University of Arizona College of Medicine - Phoenix, Phoenix, AZ, United States
| | - Bentley J Bobrow
- Bureau of EMS & Trauma System, Arizona Department of Health Services, Phoenix, AZ, United States; Arizona Emergency Medicine Research Center, University of Arizona College of Medicine - Phoenix, Phoenix, AZ, United States
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13
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Timely bystander CPR improves outcomes despite longer EMS times. Am J Emerg Med 2017; 35:1049-1055. [PMID: 28237384 DOI: 10.1016/j.ajem.2017.02.033] [Citation(s) in RCA: 33] [Impact Index Per Article: 4.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/01/2016] [Revised: 02/14/2017] [Accepted: 02/15/2017] [Indexed: 11/23/2022] Open
Abstract
OBJECTIVES This study aimed to determine the impact of bystander CPR on clinical outcomes in patients with increasing response time from collapse to EMS response. METHODS A population-based observational study was conducted in patients with witnessed out-of-hospital cardiac arrest (OHCA) of presumed cardiac etiology from 2012 to 2014. The time interval from collapse to CPR by EMS providers was categorized into quartile groups: fastest group (<4min), fast group (4 to <8min), late group (8 to <15min), and latest group (15 to <30min). The primary outcome was hospital discharge and the secondary outcome was survival with good neurological outcome. Multivariable logistic regression analysis was performed to evaluate the interaction between bystander CPR and the time interval from collapse to CPR by EMS providers. RESULTS A total of 15,354 OHCAs were analyzed. Bystander CPR was performed in 8591 (56.0%). Survival to hospital discharge occurred in 1632 (10.6%) and favorable neurological outcome in 996 (6.5%). In an interaction model of bystander CPR, compared to the fastest group, adjusted odds ratios (AORs) (95% CIs) for survival to discharge were 0.89 (0.66-1.20) in the fast group, 0.76 (0.57-1.02) in the late group, and 0.52 (0.37-0.73) in the latest group. For favorable neurological outcome, AORs were 1.12 (0.77-1.62) in the fast group, 0.90 (0.62-1.30) in the late group, 0.59 (0.38-0.91) in the latest group. CONCLUSION The survival from OHCA decreases as the ambulance response time increases. The increase in mortality and worsening neurologic outcomes appear to be mitigated in those patients who receive bystander CPR.
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Min Ko RJ, Wu VX, Lim SH, San Tam WW, Liaw SY. Compression-only cardiopulmonary resuscitation in improving bystanders’ cardiopulmonary resuscitation performance: a literature review. Emerg Med J 2016; 33:882-888. [DOI: 10.1136/emermed-2015-204771] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/23/2015] [Revised: 11/12/2015] [Accepted: 12/28/2015] [Indexed: 11/03/2022]
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Cordioli RL, Lyazidi A, Rey N, Granier JM, Savary D, Brochard L, Richard JCM. Impact of ventilation strategies during chest compression. An experimental study with clinical observations. J Appl Physiol (1985) 2015; 120:196-203. [PMID: 26586906 DOI: 10.1152/japplphysiol.00632.2015] [Citation(s) in RCA: 41] [Impact Index Per Article: 4.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/27/2015] [Accepted: 11/13/2015] [Indexed: 11/22/2022] Open
Abstract
The optimal ventilation strategy during cardiopulmonary resuscitation (CPR) is unknown. Chest compression (CC) generates circulation, while during decompression, thoracic recoil generates negative pressure and venous return. Continuous flow insufflation of oxygen (CFI) allows noninterrupted CC and generates positive airway pressure (Paw). The main objective of this study was to assess the effects of positive Paw compared with the current recommended ventilation strategy on intrathoracic pressure (P(IT)) variations, ventilation, and lung volume. In a mechanical model, allowing compression of the thorax below an equilibrium volume mimicking functional residual capacity (FRC), CC alone or with manual bag ventilation were compared with two levels of Paw with CFI. Lung volume change below FRC at the end of decompression and P(IT), as well as estimated alveolar ventilation, were measured during the bench study. Recordings were obtained in five cardiac arrest patients to confirm the bench findings. Lung volume was continuously below FRC, and as a consequence P(IT) remained negative during decompression in all situations, including with positive Paw. Compared with manual bag or CC alone, CFI with positive Paw limited the fall in lung volume and resulted in larger positive and negative P(IT) variations. Positive Paw with CFI significantly augmented ventilation induced by CC. Recordings in patients confirmed a major loss of lung volume below FRC during CPR, even with positive Paw. Compared with manual bag ventilation, positive Paw associated with CFI limits the loss in lung volume, enhances CC-induced positive P(IT), maintains negative P(IT) during decompression, and generates more alveolar ventilation.
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Affiliation(s)
- Ricardo L Cordioli
- University Hospital of Geneva, Intensive Care Unit, Geneva, Switzerland; Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil; Intensive Care Unit, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil;
| | - Aissam Lyazidi
- University Hospital of Geneva, Intensive Care Unit, Geneva, Switzerland; Laboratoire Rayonnement-Matière et Instrumentation, Département de Physique, Université Hassan 1er, Settat, Morocco; Institut Supérieur des Sciences de la Santé, Université Hassan 1er, Settat, Morocco
| | - Nathalie Rey
- Department of Anesthesia and Intensive Care Unit, Rouen, France
| | - Jean-Max Granier
- University Hospital of Geneva, Intensive Care Unit, Geneva, Switzerland
| | - Dominique Savary
- Emergency and Intensive Care Department, General Hospital of Annecy, Annecy, France
| | - Laurent Brochard
- Keenan Research Centre, St Michael's Hospital, Toronto, Ontario, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada; INSERM UMR 955, Creteil, France
| | - Jean-Christophe M Richard
- Emergency and Intensive Care Department, General Hospital of Annecy, Annecy, France; INSERM UMR 955, Creteil, France
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Cherry BH, Nguyen AQ, Hollrah RA, Williams AG, Hoxha B, Olivencia-Yurvati AH, Mallet RT. Pyruvate stabilizes electrocardiographic and hemodynamic function in pigs recovering from cardiac arrest. Exp Biol Med (Maywood) 2015; 240:1774-84. [PMID: 26088865 DOI: 10.1177/1535370215590821] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/12/2015] [Accepted: 05/05/2015] [Indexed: 11/15/2022] Open
Abstract
Cardiac electromechanical dysfunction may compromise recovery of patients who are initially resuscitated from cardiac arrest, and effective treatments remain elusive. Pyruvate, a natural intermediary metabolite, energy substrate, and antioxidant, has been found to protect the heart from ischemia-reperfusion injury. This study tested the hypothesis that pyruvate-enriched resuscitation restores hemodynamic, metabolic, and electrolyte homeostasis following cardiac arrest. Forty-two Yorkshire swine underwent pacing-induced ventricular fibrillation and, after 6 min pre-intervention arrest, 4 min precordial compressions followed by transthoracic countershocks. After defibrillation and recovery of spontaneous circulation, the pigs were monitored for another 4 h. Sodium pyruvate or NaCl were infused i.v. (0.1 mmol·kg(-1)·min(-1)) throughout precordial compressions and the first 60 min recovery. In 8 of the 24 NaCl-infused swine, the first countershock converted ventricular fibrillation to pulseless electrical activity unresponsive to subsequent countershocks, but only 1 of 18 pyruvate-treated swine developed pulseless electrical activity (relative risk 0.17; 95% confidence interval 0.13-0.22). Pyruvate treatment also lowered the dosage of vasoconstrictor phenylephrine required to maintain systemic arterial pressure at 15-60 min recovery, hastened clearance of excess glucose, elevated arterial bicarbonate, and raised arterial pH; these statistically significant effects persisted up to 3 h after sodium pyruvate infusion, while infusion-induced hypernatremia subsided. These results demonstrate that pyruvate-enriched resuscitation achieves electrocardiographic and hemodynamic stability in swine during the initial recovery from cardiac arrest. Such metabolically based treatment may offer an effective strategy to support cardiac electromechanical recovery immediately after cardiac arrest.
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Affiliation(s)
- Brandon H Cherry
- Department of Integrative Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA Institute of Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA
| | - Anh Q Nguyen
- Department of Integrative Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA
| | - Roger A Hollrah
- Department of Integrative Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA
| | - Arthur G Williams
- Department of Integrative Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA
| | - Besim Hoxha
- Department of Emergency Medicine, Baylor College of Medicine, Houston, TX 77030, USA
| | - Albert H Olivencia-Yurvati
- Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA Department of Surgery, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA
| | - Robert T Mallet
- Department of Integrative Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA Department of Surgery, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA
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Cherry BH, Nguyen AQ, Hollrah RA, Olivencia-Yurvati AH, Mallet RT. Modeling cardiac arrest and resuscitation in the domestic pig. World J Crit Care Med 2015; 4:1-12. [PMID: 25685718 PMCID: PMC4326759 DOI: 10.5492/wjccm.v4.i1.1] [Citation(s) in RCA: 40] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/08/2014] [Revised: 11/03/2014] [Accepted: 12/01/2014] [Indexed: 02/06/2023] Open
Abstract
Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation (CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest.
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Hasegawa T, Daikoku R, Saito S, Saito Y. Relationship between weight of rescuer and quality of chest compression during cardiopulmonary resuscitation. J Physiol Anthropol 2014; 33:16. [PMID: 24957919 PMCID: PMC4079182 DOI: 10.1186/1880-6805-33-16] [Citation(s) in RCA: 68] [Impact Index Per Article: 6.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/16/2014] [Accepted: 06/13/2014] [Indexed: 12/31/2022] Open
Abstract
Background According to the guidelines for cardiopulmonary resuscitation (CPR), the rotation time for chest compression should be about 2 min. The quality of chest compressions is related to the physical fitness of the rescuer, but this was not considered when determining rotation time. The present study aimed to clarify associations between body weight and the quality of chest compression and physical fatigue during CPR performed by 18 registered nurses (10 male and 8 female) assigned to light and heavy groups according to the average weight for each sex in Japan. Methods Five-minute chest compressions were then performed on a manikin that was placed on the floor. Measurement parameters were compression depth, heart rate, oxygen uptake, integrated electromyography signals, and rating of perceived exertion. Compression depth was evaluated according to the ratio (%) of adequate compressions (at least 5 cm deep). Results The ratio of adequate compressions decreased significantly over time in the light group. Values for heart rate, oxygen uptake, muscle activity defined as integrated electromyography signals, and rating of perceived exertion were significantly higher for the light group than for the heavy group. Conclusion Chest compression caused increased fatigue among the light group, which consequently resulted in a gradual fall in the quality of chest compression. These results suggested that individuals with a lower body weight should rotate at 1-min intervals to maintain high quality CPR and thus improve the survival rates and neurological outcomes of victims of cardiac arrest.
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Affiliation(s)
- Tomoyuki Hasegawa
- Graduate School of Health Care Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8510, Japan.
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Shin SD, Ahn KO, Song KJ, Park CB, Lee EJ. Out-of-hospital airway management and cardiac arrest outcomes: A propensity score matched analysis. Resuscitation 2012; 83:313-9. [DOI: 10.1016/j.resuscitation.2011.10.028] [Citation(s) in RCA: 84] [Impact Index Per Article: 6.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/19/2011] [Revised: 07/11/2011] [Accepted: 10/25/2011] [Indexed: 12/17/2022]
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Botran M, Lopez-Herce J, Urbano J, Solana MJ, Garcia A, Carrillo A. Chest compressions versus ventilation plus chest compressions: a randomized trial in a pediatric asphyxial cardiac arrest animal model. Intensive Care Med 2011; 37:1873-80. [PMID: 21847647 DOI: 10.1007/s00134-011-2338-6] [Citation(s) in RCA: 19] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/30/2011] [Accepted: 07/17/2011] [Indexed: 10/17/2022]
Abstract
PURPOSE To compare survival, oxygenation, ventilation, and hemodynamic variables achieved with chest compressions or ventilation plus chest compressions. METHODS This randomized experimental study was conducted in the experimental department of a university hospital. Thirty infant pigs with asphyxial cardiac arrest were randomized into two groups of cardiopulmonary resuscitation (CPR): group 1, continuous chest compressions plus non-coordinated ventilation with a mask and mechanical ventilator (inspired oxygen fraction 0.21) (VC); group 2, chest compressions only (CC). Nine minutes of basic resuscitation was performed initially in both groups, followed by advanced resuscitation. CPR was terminated on achieving return of spontaneous circulation (ROSC) or after 30 min of total resuscitation time without ROSC. RESULTS Three animals (18.8%) in the VC group and 1 (7.1%) in the CC group achieved ROSC (P = 0.351). Oxygenation and ventilation during basic CPR were insufficient in both groups, though they were significantly better in the VC group than in the CC group after 9 min (PaO(2), 26 vs. 19 mmHg, P = 0.008; PaCO(2), 84 vs. 101 mmHg, P = 0.05). Cerebral saturation was higher in the VC group (61%) than in the CC group (30%) (P = 0.06). There were no significant differences in mean arterial pressure. CONCLUSIONS Neither of the basic CPR protocols achieved adequate oxygenation and ventilation in this model of asphyxial pediatric cardiac arrest. Chest compressions plus ventilation produced better oxygenation, ventilation, and cerebral oxygenation with no negative hemodynamic effects. Survival was higher in the VC group, though the difference was not statistically significant.
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Affiliation(s)
- Marta Botran
- Pediatric Intensive Care Department, Hospital General Universitario Gregorio Marañón, C/Doctor Castelo 47, 28009, Madrid, Spain
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Mohler MJ, Wendel CS, Mosier J, Itty A, Fain M, Clark L, Bobrow B, Sanders AB. Cardiocerebral Resuscitation Improves Out-of-Hospital Survival in Older Adults. J Am Geriatr Soc 2011; 59:822-6. [DOI: 10.1111/j.1532-5415.2011.03400.x] [Citation(s) in RCA: 18] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/29/2022]
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Reanimación cardiopulmonar avanzada (segunda parte) los cambios que deben efectuarse para la reanimación cardiovascular avanzada según las guías 2010 presentadas en chicago. REVISTA COLOMBIANA DE CARDIOLOGÍA 2011. [DOI: 10.1016/s0120-5633(11)70168-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/24/2022] Open
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Ewy GA, Hilwig RW, Zuercher M, Sattur S, Sanders AB, Otto CW, Schuyler T, Kern KB. Continuous chest compression resuscitation in arrested swine with upper airway inspiratory obstruction. Resuscitation 2010; 81:585-90. [DOI: 10.1016/j.resuscitation.2010.01.009] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/15/2009] [Revised: 01/11/2010] [Accepted: 01/18/2010] [Indexed: 11/30/2022]
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