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Liu Y, Ren M, Kuang Z, Luo X, Li H, Zhang Y, Wen W, Cai Y, Ni X, Chen Y. Efficacy of acupuncture for cardiopulmonary cerebral resuscitation: A systematic review and meta-analysis. Integr Med Res 2023; 12:100925. [PMID: 36865050 PMCID: PMC9971281 DOI: 10.1016/j.imr.2023.100925] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/21/2022] [Revised: 01/31/2023] [Accepted: 01/31/2023] [Indexed: 02/07/2023] Open
Abstract
Background Cerebral resuscitation is one of the main therapeutic aims in the treatment of cardiac arrest (CA) patients who experience a return of spontaneous circulation (ROSC). However, the therapeutic effects of current treatments are not ideal. The purpose of this study was to evaluate the efficacy of neurological function of acupuncture combined with conventional cardiopulmonary cerebral resuscitationthe (CPCR) for patients after ROSC. Methods Seven electronic databases and other related websites were searched to identify studies on acupuncture combined with conventional CPCR for patients after ROSC. R software was used to conduct a meta-analysis, and the outcomes that could not be pooled were analyzed using a descriptive analysis. Results Seven RCTs involving 411 participants who had experienced ROSC were eligible for inclusion. The main acupoints were Neiguan (PC6), Shuigou (DU26), Baihui (DU20), Yongquan (KI1), and Sanyinjiao (SP6). Compared to conventional CPCR, acupuncture combined with conventional CPCR led to significantly higher Glasgow Coma Scale (GCS) scores on day 3 (mean difference (MD)=0.89, 95% CI: 0.43, 1.35, I2 = 0%), day 5 (MD = 1.21, 95% CI: 0.27, 2.15; I2 = 0%), and day 7 (MD = 1.92, 95% CI: 1.35, 2.50; I2 = 0%). Conclusion Acupuncture-assisted conventional CPCR may have a potential role in improving neurological function in CA patients after ROSC, but the certainty of evidence is very low and more high-quality studies are required. Protocol registration This review was registered at the International Prospective Registry of Systematic Reviews (PROSPERO): CRD42021262262.
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Affiliation(s)
- Yunlan Liu
- School of Public Health, Lanzhou University, Lanzhou, China
| | - Mengjuan Ren
- School of Public Health, Lanzhou University, Lanzhou, China
| | - Zhuoran Kuang
- Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
| | - Xufei Luo
- Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
| | - Huishan Li
- Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
| | - Yikai Zhang
- Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
| | - Wanxin Wen
- Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
| | - Yefeng Cai
- Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China,Guangdong Provincial Key Laboratory of Research on Emergency in Traditional Chinese Medicine, Guangzhou, China
| | - Xiaojia Ni
- Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China,Guangdong Provincial Key Laboratory of Research on Emergency in Traditional Chinese Medicine, Guangzhou, China,Corresponding authors at: Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China (X. Ni); Institute of Health Data Science, Lanzhou University, Lanzhou, China (Y. Chen).
| | - Yaolong Chen
- School of Public Health, Lanzhou University, Lanzhou, China,Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China,Research Unit of Evidence-Based Evaluation and Guidelines, Chinese Academy of Medical Sciences (2021RU017), School of Basic Medical Sciences, Lanzhou University, Lanzhou, China,Lanzhou University, an Affiliate of the Cochrane China Network, Lanzhou, China,Lanzhou University GRADE Center, Lanzhou, China,Corresponding authors at: Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China (X. Ni); Institute of Health Data Science, Lanzhou University, Lanzhou, China (Y. Chen).
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Inchauspe AA. COVID-19 and resuscitation: La tournée of traditional Chinese medicine? World J Crit Care Med 2021; 10:151-162. [PMID: 34316449 PMCID: PMC8291005 DOI: 10.5492/wjccm.v10.i4.151] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/10/2021] [Revised: 05/01/2021] [Accepted: 06/02/2021] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND As it has been established in previous publications of the author, the current extra-hospital statistics referring to cardiopulmonary resuscitation (CPR) are far from being minimally satisfactory (14%-17% success). Since the appearance of acquired immune deficiency syndrome, its application has been increasingly undermined as other subsequent pandemics (H1N1, Ebola, coronavirus disease 2019) seriously infringing lay rescuers intervention during classical CPR steps (mouth-to-mouth ventilation), forcing to modify vital support protocols. Both KI-1 Yong quan and PC-9 Zhong chong alternative rescue maneuvers could come to aid those victims of impending death situation due to both cardiac arrest or stroke, upgrading current survival rates of said unfortunate patients. AIM To validate a complementary resuscitation maneuver originated in Chinese Medicine knowledge, carefully integrated into international CPR protocols [World Journal of Critical Care Medicine (WJCCM), August 2013]. METHODS The model to verify its statistical validity of quoted research was the Retrospective Cohort Study, which redeems the "semiotic paradigm" that gave rise to medical semiotics. Its value strives in the differential detail if the deceased patients are considered the control group instead of the patients that may be deceased. Thus, combining the semiotic paradigm with the Retrospective Cohort Study allows us to manage the collateral potential lethal effects of the random process in cases of extreme emergencies. RESULTS The statistic results provided by the methodological analysis of this work were previously published in WJCCM August 2013, ISSN 2220-3141). In a total of 89 patients in which the Yong quan maneuver was tested, 75 survived and 14 died. In order to compare this data with the percentages of survivors in the other maneuvers, we stipulate the assumption that if 89 patients are the 100% of the sample, how many patients would survive if the survival rate is 6.4% in CPR, 30% in defibrillation and 48% in CPR + defibrillation. By this way we obtained the approximate values of patients that would survive when applying these classical resuscitation maneuvers. Then we obtained the format of the tables to perform the exact Fisher test with the help of a statistical processor; the consequent result in a valuation of P < 0.0001 was considered "extremely statistically significant". CONCLUSION The author herein provides a methodological-statistical analysis of such contribution which does not imply any cost at all and could even help prevent the withdrawal of classical CPR practices.
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Affiliation(s)
- Adrian A Inchauspe
- Chronic and Acute Care, Neuro-psychiatric Hospital Interzonal "Dr. Alejandro Korn", Melchor Romero, Berazategui 1884, Buenos Aires, Argentina
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Faiz SHR, Nikoubakht N, Imani F, Ziyaeifard M, Sadegh H, Rahimzadeh P. Comparison of Two Acupuncture Protocols (K1, DU25 or K1, DU26) Efficacy on Recovery Time of Patients After General Anesthesia, a Randomized Control Clinical Trial. Anesth Pain Med 2019; 9:e96172. [PMID: 31903336 PMCID: PMC6935292 DOI: 10.5812/aapm.96172] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/09/2019] [Revised: 08/21/2019] [Accepted: 08/27/2019] [Indexed: 12/16/2022] Open
Abstract
Background Acupuncture has been used for more than two thousand years as part of traditional Chinese medicine. Objectives This randomized prospective clinical trial aimed to compare the effect of acupuncture on K1 (Yongquan) and DU26 (Renghong) with acupuncture on K1 (Yongquan) and DU25 (Suliao), with sham acupuncture on the recovery time of general anesthesia. Methods The patients (51) were randomly assigned to three groups: (A) acupuncture on K1 and DU26, (B) acupuncture on K1 and DU25, and (C) sham acupuncture. In each group, at the end of surgery acupuncture was performed accordingly for twenty minutes and the Bispectral Index (BIS) values at end of surgery, 5th minute, 10th minute, 15th minute and 20th minute as well as time of extubation and time of eye opening after the end of surgery were evaluated. Results BIS study at 5th minute, 10th minute and 15th minute after the end of surgery in the groups revealed a significant difference between sham acupuncture group and both A and B acupuncture groups, which was higher in groups A and B in comparison with sham acupuncture group. Time of opening eyes and time of extubation after the end of surgery between group A and sham acupuncture group differed significantly, which was earlier in group A. There was no significant difference between group B and sham acupuncture group in terms of eye opening and extubation time. Conclusions Acupuncture on K1 and DU26 accelerates restoring of consciousness and shortens of eye opening and extubation after general anesthesia, but on K1 and DU25 only speeds up retrieving of consciousness without significant effect on time of eye opening or extubation after general anesthesia.
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Affiliation(s)
- Seyed Hamid Reza Faiz
- Pain Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
| | - Nasim Nikoubakht
- Pain Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
| | - Farnad Imani
- Pain Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
| | - Mohsen Ziyaeifard
- Rajaie Cardiovascular Medical & Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran
| | - Hossein Sadegh
- Iran University of Medical Sciences (IUMS), Tehran, Iran
| | - Poupak Rahimzadeh
- Pain Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
- Corresponding Author: Professor of Anesthesiology, Pain Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.
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Li S, Cao G, Deng Q, Zhu D, Yan F. Effect of Pushen capsule for treating vascular mild cognitive impairment: a pilot observational study. J Int Med Res 2019; 47:5483-5496. [PMID: 31407622 PMCID: PMC6862923 DOI: 10.1177/0300060519859766] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/01/2023] Open
Abstract
Objective Traditional Chinese medicine (TCM) may be beneficial for vascular dementia (VaD). We evaluated the efficacy of Pushen capsule, a compound containing several TCM components, for treating vascular mild cognitive impairment (VaMCI). Methods Seventy outpatients with VaMCI were randomized to Pushen capsule or control treatment with Ginkgo biloba. Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Subjective Memory Loss Rating Scale scores; and lipid, lipoprotein, and haemorheological parameters were collected at baseline, week 4, and week 12 of treatment. Results MMSE score at week 12 was significantly higher in the treatment group compared with baseline (t = −2.352) but was not significantly different from week 12 in the control group. The MoCA score at week 12 was higher than that at baseline for both the treatment and control groups (t = −2.619 and −2.582, respectively), as was the “delayed recall” item score. Subjective memory loss score and the cognitive function “forgetting acquaintance's name” were significantly higher in the treatment group at week 12 than at baseline (t = −2.621 and χ2 = 4.419, respectively). Lipid, lipoprotein, and haemorheological parameters were significantly different after treatment in both groups. Conclusion The benefits of Pushen capsule on cognitive function in VaMCI were comparable with that of Ginkgo biloba.
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Affiliation(s)
- Shuo Li
- Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China
| | - Geyin Cao
- Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China
| | - Qiwen Deng
- Department of Neurology, Nanjing First hospital, Nanjing, China
| | - Dan Zhu
- Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China
| | - Fuling Yan
- Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China
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Abstract
The Lazarus phenomenon or the unassisted return of spontaneous circulation after cardiac arrest is a grossly underreported phenomenon in medical literature which essentially implies the ‘resurrection’ of an individual after cardiac arrest. Although there have been a handful of such cases reported, the clinical incidence and significance may be underestimated. Because of the presumed infrequency of this condition, there are no studies specifically researching Lazarus phenomenon in scientific literature. This review intends to systematically present current and past knowledge on this rare but definitive phenomenon. Research databases namely Google Scholar, Science Direct, Medline and PubMed were utilized. Only articles which identified cases where the return of spontaneous circulation occurred after cessation of Cardiopulmonary Resuscitation (CPR), and review articles on the entity were included. The mentioned databases were searched using the terms ‘Lazarus phenomenon’, ‘cardiopulmonary resuscitation’ and ‘return of spontaneous circulation’. A literature review was synthesised based on articles meeting the eligibility criteria to better understand the phenomenon of return of spontaneous circulation.
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Affiliation(s)
- Vaibhav Sahni
- Maharishi Markandeshwar College of Dental Sciences and Research, MMU, Haryana 133203, India
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Inchauspe AA. Can PC-9 Zhong chong replace K-1 Yong quan for the acupunctural resuscitation of a bilateral double-amputee? Stating the “random criterion problem” in its statistical analysis. World J Crit Care Med 2016; 5:143-149. [PMID: 27152257 PMCID: PMC4848157 DOI: 10.5492/wjccm.v5.i2.143] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/03/2015] [Revised: 12/13/2015] [Accepted: 01/19/2016] [Indexed: 02/06/2023] Open
Abstract
AIM: To present an inclusion criterion for patients who have suffered bilateral amputation in order to be treated with the supplementary resuscitation treatment which is hereby proposed by the author.
METHODS: This work is based on a Retrospective Cohort model so that a certainly lethal risk to the control group is avoided.
RESULTS: This paper presents a hypothesis on acupunctural PC-9 Zhong chong point, further supported by previous statistical work recorded for the K-1 Yong quan resuscitation point.
CONCLUSION: Thanks to the application of the resuscitation maneuver herein proposed on the previously mentioned point, patients with bilateral amputation would have another alternative treatment available in case basic and advanced CPR should fail.
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Gemma M, Nicelli E, Gioia L, Moizo E, Beretta L, Calvi MR. Acupuncture accelerates recovery after general anesthesia: a prospective randomized controlled trial. JOURNAL OF INTEGRATIVE MEDICINE-JIM 2015; 13:99-104. [PMID: 25797640 DOI: 10.1016/s2095-4964(15)60159-5] [Citation(s) in RCA: 15] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 10/23/2022]
Abstract
BACKGROUND Acupuncture anesthesia was created in the 1950's in China and continues to be used there today during most major surgeries. It is widely used in China for such complex operations as brain, heart, and abdominal surgery. It is popular in China because it is economical, practical, and beneficial to the patients. With acupuncture anesthesia there is less bleeding during surgery and there is also quicker post-operative recovery. OBJECTIVE This randomized prospective study aims at comparing the effect of two acupoints (Yongquan, KI1 and Renzhong, DU26) with sham acupuncture and no acupuncture on the time to recovery of consciousness after general anesthesia by means of the Bispectral Index monitor (BIS). DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS This is a prospective randomized controlled study. We randomly assigned 50 patients to 5 groups during recovery from surgical anesthesia. Four groups had acupuncture on KI1 (group A), DU26 (groups B), both KI1 and DU26 (group C), and sham points (group D), and one had no acupuncture (group E). MAIN OUTCOME MEASURES Bispectral Index (BIS), time to spontaneous eye opening, time to tracheal extubation, and time to following commands were measured as the main outcome measures. RESULTS Time to spontaneous eye opening differed among groups (P=0.002), as well as time to tracheal extubation (P<0.000 1) and time to following commands (P=0.000 6). BIS values differed significantly among groups both 5 and 10 min after the end of anesthesia (P<0.000 1 and P=0.000 4, respectively). BIS values of groups D and E were lower than those of the other groups and those of group C were higher. The same pattern was observed also 15 and 30 min after the end of anesthesia, although the difference among groups was not significant at these time points (P=0.164 and P=0.104, respectively). CONCLUSION Acupuncture on DU26 and KI1 accelerates recovery of consciousness after general anesthesia. Moreover, a possible synergistic effect of DU26 and KI1 is suggested. This issue may play a role in the optimization of operating room management and raise interest about the usefulness of acupuncture on unconsciousness states of different nature.
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Affiliation(s)
- Marco Gemma
- Department of Anesthesia and Neurointensive Care, San Raffaele Scientific Institute, 20132 Milan, Italy
| | - Elisa Nicelli
- Department of Anesthesia and Neurointensive Care, San Raffaele Scientific Institute, 20132 Milan, Italy
| | - Luigi Gioia
- Department of Anesthesia and Neurointensive Care, San Raffaele Scientific Institute, 20132 Milan, Italy
| | - Elena Moizo
- Department of Anesthesia and Neurointensive Care, San Raffaele Scientific Institute, 20132 Milan, Italy
| | - Luigi Beretta
- Department of Anesthesia and Neurointensive Care, San Raffaele Scientific Institute, 20132 Milan, Italy
| | - Maria Rosa Calvi
- Department of Anesthesia and Neurointensive Care, San Raffaele Scientific Institute, 20132 Milan, Italy
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Inchauspe AÁ. Resuscitation on the K-1 Yongquan: Ethical and Methodological Aspects of Its Pilot Study. Health (London) 2015. [DOI: 10.4236/health.2015.77095] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/17/2022]
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Inchauspe AA. Drawing the Yongquan protocol into the different stages of the cardiopulmonary resuscitation sequence. World J Crit Care Med 2013; 2:17-20. [PMID: 24701412 PMCID: PMC3953857 DOI: 10.5492/wjccm.v2.i3.17] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/18/2012] [Revised: 12/20/2012] [Accepted: 06/04/2013] [Indexed: 02/06/2023] Open
Abstract
AIM: To introduce new applications into the ILCOR-cardiopulmonary resuscitation (CPR) “chain” sequence.
METHODS: Stages of the CPR sequence (“chain”): prior to the application of chest massage: assess the victim’s state of consciousness and lung-heart failure; seek help (call 911), or in situations in which it is impossible to start the ILCOR protocol: (1) if the victim is trapped in car crash, overturned car, landslide, massive number of victims or catastrophe; or (2) delayed CPR. During chest compression: Yongquan is simultane- ously stimulated by a third rescuer. During defibrillator application: activate K-1 Yongquan through needles before defibrillation. Unsuccessful CPR: “gold standard” for legal clinical death.
RESULTS: Implies comparing two hypotheses: Ho (null hypothesis) demonstrates no association between the two variables studied; Ha (alternative hypothesis) implies some degree of relation between them. Difference between the two treatments is observed. If it is greater than the standard error multiplied by a coefficient of security, the difference is significant: Ha will be accepted and Ho rejected. First we will compare CPR without defibrillator (method “A”) and K-1 Yongquan method (method “B”), using percentages of representative samples (treatment “A”: 6.4% response, treatment “B”: 85% response). If │PA - PB│ is greater than the product of 1.96 times the standard error, the difference is significant. Because │PA - PB│ = 0.786 is greater than 0.098, the difference between 0.064 and 0.85 is statistically significant. Thus, we reject Ho and accept Ha as correct. Thus, it is improbable that chance was responsible for this association. This analysis shows that K-1 Yongquan method has a “quality guarantee”. Second, we compare defibrillators (“A”) with K-1 Yongquan method (“B”) (treatment “A”: 48%, treatment “B”: 84%, │PA - PB│= 0.36; │PA - PB│ = 0.36 is greater than SE × 1.96 = 0.0148 and also statistically significant, demonstrating again the comparative value of the Yongquan method.
CONCLUSION: The Yongquan resuscitation manoeuver is a non-invasive, non-tiring, costless, and easy-to-apply procedure that provides a second chance when other options fail.
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Tong Y, Yu Q, Leng Y. Hypotensive Effects Induced by Herbal Fomentation at Yongquan Point. J Acupunct Meridian Stud 2012; 5:305-9. [DOI: 10.1016/j.jams.2012.07.020] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/27/2012] [Revised: 05/29/2012] [Accepted: 06/21/2012] [Indexed: 11/27/2022] Open
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Tong Y, Yu Q, Leng Y. Chinese herbal fomentation at the Yongquan point (K1): a potential hypotensive regimen. J Altern Complement Med 2012; 18:1168-71. [PMID: 23046294 DOI: 10.1089/acm.2011.0679] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022] Open
Abstract
OBJECTIVE The goal of this research was to assess the adequacy of blood pressure (BP) control by applying Chinese herbal fomentation (a type of thermotherapy) at the Yongquan point (K1). METHODS A total of 102 patients with hypertension, ages 39-55, were included in this study. After a baseline examination, each enrolled patient participated in one session per day lasting 24 hours for 3 continuous days, during which the Yongquan point (K1) on both sides of the body were fomented (given thermotherapy) with a mixture of Chinese herbs. In addition, 24-hour ambulatory BP (ABP) monitoring (ABPM) was repeated at baseline and on the day after the therapy. RESULTS Patients had significantly lower daytime systolic and diastolic BP post-treatment. There were no significant changes in 24-hour, or night-time systolic BP (SBP), diastolic BP (DBP), or mean arterial BP, and in pulse pressure after therapy. The rate of adverse events was 0.98% in these patients. CONCLUSIONS The regimen sustained SBP and DBP control during the day for the majority of patients. This study suggested that a Chinese herbal fomentated at the Yongquan point (K1) of both sides of the body has some hypotensive potential.
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Affiliation(s)
- YanQing Tong
- Department of Nephrology, The First Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China.
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Inchauspe AA. Torsadogenic index: a proposal to improve survival rates in cardiac arrests due to prescribed drugs. Front Pharmacol 2012; 3:99. [PMID: 22712017 PMCID: PMC3375041 DOI: 10.3389/fphar.2012.00099] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/16/2012] [Accepted: 05/04/2012] [Indexed: 11/13/2022] Open
Abstract
Since unexpected sudden deaths have been reported with the use of diverse non-cardiac drugs, cardio-safety experts focused their attention on security measures to improve survival rates in heart stoppages due to this prescribed drugs (Inchauspe 2010a). Considering that prolongation of the QTc is a reliable marker of a menacing arrhythmia called torsade de pointes (TdP) – that can progress to ventricular fibrillation, application of Bazett, or Rautaharhu formulas can lead to a proper predictive valuation of a “torsadogenic risk.” Case-analysis raises up the proposal that QTc or QTp will allow to identify high risk groups; performs a close pharmaco-vigilance and legally register ECG follow-up, avoiding unnecessary withdrawal of useful drugs from market.
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Affiliation(s)
- Adrián Angel Inchauspe
- Hospital "Dr. Alejandro Korn" - Melchor Romero - La Plata, Provincia de Buenos Aires Argentina
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