Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.142
Peer-review started: April 29, 2015
First decision: June 3, 2015
Revised: June 18, 2015
Accepted: July 24, 2015
Article in press: July 27, 2015
Published online: November 27, 2015
Processing time: 213 Days and 14.2 Hours
Core tip: Combination of Helicobacter pylori (H. pylori) and host-associated risk factors do not always allow evaluation of gastric carcinoma. We have learnt that the assessment of patients with H. pylori infection and its strain is very important and concluded that eradication of bacteria has essential meaning. We recommend that not only screening for H. pylori also the strain determination should have some diagnostic value, especially in the patients who already developed gastritis. Furthermore, for such patients assessment of disease progression could be followed by polymorphism determination. Conclusions indicate that host cytokine genotypes, host immune response, as well as H. pylori strains could be important for greater risk for developing gastric cancer.