Review
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World J Immunol. Nov 27, 2014; 4(3): 158-173
Published online Nov 27, 2014. doi: 10.5411/wji.v4.i3.158
Apoptotic signaling through reactive oxygen species in cancer cells
Daejin Kim, Ga Bin Park, Dae Young Hur
Daejin Kim, Ga Bin Park, Dae Young Hur, Department of Anatomy and Research Center for Tumor Immunology, Inje University College of Medicine, Busan 614-735, South Korea
Author contributions: Kim D and Park GB designed the review and wrote the paper; Hur DY contributed to the editing of whole review.
Correspondence to: Dae Young Hur, MD, PhD, Department of Anatomy and Research Center for Tumor Immunology, Inje University College of Medicine, Bokjiro-75, Jin-gu, Busan 614-735, South Korea. dyhur@inje.ac.kr
Telephone: +82-51-8906796 Fax: +82-51-8966634
Received: March 27, 2014
Revised: June 3, 2014
Accepted: October 14, 2014
Published online: November 27, 2014
Processing time: 236 Days and 23.3 Hours
Core Tip

Core tip: Reactive oxygen species originally used to induce injurious cellular effects are now recognized as key physiological molecules for the induction of host defense genes, activation of transcription factors, and regulation of signal transduction. Tumorigenic cells can induce a new redox balance, resulting in cellular adaptation and proliferation. Here, we review the role of oxidative stress in cancer cells using a pathophysiological view.