Singh B, Singh H, Kaur S, Singh B. Preclinical pharmacology studies of zingerone with special reference to potential therapeutic applications. World J Immunol 2026; 16(1): 111511 [DOI: 10.5411/wji.v16.i1.111511]
Corresponding Author of This Article
Balbir Singh, PhD, Professor, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Grand Trunk Road, Off NH 1, Amritsar 143005, India. balbir.pharma@gndu.ac.in
Research Domain of This Article
Pharmacology & Pharmacy
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 8, 2026 (publication date) through Jan 9, 2026
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Immunology
ISSN
2219-2824
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Singh B, Singh H, Kaur S, Singh B. Preclinical pharmacology studies of zingerone with special reference to potential therapeutic applications. World J Immunol 2026; 16(1): 111511 [DOI: 10.5411/wji.v16.i1.111511]
Brahmjot Singh, Hasandeep Singh, Sarabjit Kaur, Balbir Singh, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, India
Author contributions: Singh B contributed to investigation, writing - original draft; Singh H contributed to data curation; Kaur S contributed to visualization; Singh B contributed to supervision; Singh B and Singh B contributed to validation, methodology, conceptualization; Singh H and Kaur S contributed to formal analysis.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Balbir Singh, PhD, Professor, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Grand Trunk Road, Off NH 1, Amritsar 143005, India. balbir.pharma@gndu.ac.in
Received: July 2, 2025 Revised: August 16, 2025 Accepted: November 25, 2025 Published online: January 8, 2026 Processing time: 189 Days and 23.1 Hours
Core Tip
Core Tip: Zingerone is one of the potent natural bioactive molecules isolated from the ginger, a natural spice distributes all over the world. In this review, we have identified that zingerone possesses several pharmacological properties such as potent anti-oxidant, anti-inflammatory, anti-apoptotic, antiproliferative effects in pre-clinical studies. These properties suggest that the zingerone is more beneficial in curing several disorders. However, exploration of structure activity relationship could be useful to enhance its stability, safety and effectiveness. Thus, there is a need of future exploration for the therapeutic potential of zingerone in clinical studies. On the basis of literature reviews, it is concluded that zingerone possesses a great potential against various diseases.
