Peer-review started: July 2, 2021
First decision: July 30, 2021
Revised: August 13, 2021
Accepted: July 24, 2022
Article in press: July 24, 2022
Published online: August 24, 2022
Processing time: 416 Days and 6.4 Hours
Core Tip: Coronavirus disease 2019 (COVID-19) vaccines have created concerns about their efficacy and safety, notably in autoimmune patients. Which vaccine adverse events are related to the underlying autoimmunity is unclear. Additional data is needed to evaluate the immunological impact of COVID-19 vaccines in terms of effectiveness and immune-driven adverse effects that might provoke a disease flare in individuals with a history of autoimmune-related symptoms. However, the risk of autoimmune disease flare after vaccination was considered low, while the immune responses after vaccination showed great immunogenicity for these patients. In addition, vaccination will considerably decrease related morbidity and mortality from COVID-19 in autoimmune patients.
