©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Urol. Mar 24, 2015; 4(1): 38-47
Published online Mar 24, 2015. doi: 10.5410/wjcu.v4.i1.38
Published online Mar 24, 2015. doi: 10.5410/wjcu.v4.i1.38
Genetics and male infertility
Gulay Gulec Ceylan, Department of Medical Genetics, Medical School, Yildirim Beyazit University, 06520 Ankara, Turkey
Cavit Ceylan, Department of Urology, Turkiye Yuksek Ihtisas Education and Training Hospital, 06520Ankara, Turkey
Author contributions: Ceylan GG and Ceylan C contributed equally to this work.
Conflict-of-interest: There is no conflict of interest.
Correspondence to: Gulay Gulec Ceylan, MD, Department of Medical Genetics, Medical School, Yildirim Beyazit University, Bilkent, 06520 Ankara, Turkey. gulayceylan23@gmail.com
Telephone: +90-312-2912525 Fax: +90-312-2912728
Received: April 8, 2014
Peer-review started: April 8, 2014
First decision: June 6, 2014
Revised: December 21, 2014
Accepted: January 9, 2015
Article in press: January 12, 2015
Published online: March 24, 2015
Processing time: 351 Days and 6.1 Hours
Peer-review started: April 8, 2014
First decision: June 6, 2014
Revised: December 21, 2014
Accepted: January 9, 2015
Article in press: January 12, 2015
Published online: March 24, 2015
Processing time: 351 Days and 6.1 Hours
Core Tip
Core tip: In the case of being unable to be pregnant after regular unprotected intercourse for one year (6), it is defined as infertility, affecting about 10%-15% of all the couples. Male factor is responsible for about half of cases (6). Genes playing a role in testicular differentiation and full spermatogenesis are found in human Y chromosome (6). The main goal of this study is to mention the various chromosomal abnormalities and deletions of Y chromosome, which cause infertility; for this reason (14) it is important to know the genetic mechanisms that are responsible from the infertility especially for the clinicians.