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World J Clin Urol. Nov 24, 2014; 3(3): 320-324
Published online Nov 24, 2014. doi: 10.5410/wjcu.v3.i3.320
Published online Nov 24, 2014. doi: 10.5410/wjcu.v3.i3.320
Is periprostatic adipose tissue associated with aggressive tumor biology in prostate cancer?
Philip P Den Hollander, Kevin LJ Rademakers, Joep GH van Roermund, Department of Urology, Maastricht University Medical Centre, 6202 AZ Maastricht, The Netherlands
Author contributions: All the authors have contributed equally to this paper.
Correspondence to: Joep GH van Roermund, MD, PhD, Department of Urology, Maastricht University Medical Centre, P Debyelaan 25, POB 5800, 6202 AZ Maastricht, The Netherlands. joep.van.roermund@mumc.nl
Telephone: +31-43-3877258 Fax: +31-43-3875259
Received: April 29, 2014
Revised: July 17, 2014
Accepted: September 17, 2014
Published online: November 24, 2014
Processing time: 204 Days and 13.4 Hours
Revised: July 17, 2014
Accepted: September 17, 2014
Published online: November 24, 2014
Processing time: 204 Days and 13.4 Hours
Core Tip
Core tip: Globally, prostate cancer (PCa) is highly prevalent. Although the prevalence of PCa is similar across different populations, major differences in PCa incidence and mortality are seen worldwide. A contribution of environmental factors, such as obesity, may play an important role. Most studies used body mass index as a factor of obesity. However, only visceral fat is metabolically active. In a study by van Roermund et al, periprostatic fat measured on a computed tomography scan correlated with tumor aggressiveness. In this review, we aim to give more insight into the relationship between periprostatic fat and Pca aggressiveness by reviewing the recent literature.