Effectiveness of the extensively hydrolyzed formulas in the management of infantile colic: A systematic review and meta-analysis

Table 1 Characteristics of the included studies

Ref.	Age	Intervention	Comparator	Outcome	Main results
Hill et al[10], 1995	4-16 weeks	19 infants -hydrolysate formula (casein based)	19 infants -regular cow's milk formula	Crying time reduction	61% positive in intervention (12/19)- 43% in comparator (8/19)
Lucassen et al[11], 2000	< 6 months	20 infants -hydrolysate formula (whey based)	18 infants - regular cow's milk formula	Crying time reduction	13/20 positive in the intervention group - 6/18 in the comparator
Xinias et al[12], 2017	20-60 days	40 infants - hydrolysate formula (whey based)	20 infants -regular cow's milk formula	Crying time reduction	40/40 positive in intervention group - 13/20 in the comparator
Oggero et al[13], 1994	3-12 weeks	15 infants -Hydrolysate formula	60 infants - dicyclomine	Crying time reduction	13/15 positive in intervention group - 34/60 in comparator group
Jakobsson et al[14], 2000	2-8 weeks	14 infants -hydrolysate formula (CH1-CH2)	Same infants (13) (another time period) - Regular cow's milk formula	Decrease in crying time	11/14 positive in intervention group - 2/13 in comparator group
Forsyth[16], 1989	0-8 weeks	17 infants -Hydrolysate formula	17 infants - regular cow's milk formula	Decrease in crying time	20/51 in intervention group (out of a total of 51 formula changes from regular cow milk formula to eHF, 20 had a favorable result) - 7/51 in comparator group