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©The Author(s) 2024.
World J Clin Pediatr. Sep 9, 2024; 13(3): 94721
Published online Sep 9, 2024. doi: 10.5409/wjcp.v13.i3.94721
Published online Sep 9, 2024. doi: 10.5409/wjcp.v13.i3.94721
Table 1 Characteristics of studied groups, n (%)
Control, n = 85 | With obesity, n = 85 | P value | ||
Age of enrolment (years) | mean ± SD | 10.35 ± 2.33 | 10.48 ± 2.34 | 0.7431 |
Median [IQR] | 10.00 [9.00-12.00] | 10.00 [8.50-12.00] | ||
Sex | Male | 46 (54.1) | 35 (41.2) | 0.0912 |
Female | 39 (45.9) | 50 (58.8) | ||
Family history | DM | 19 (22.4) | 33 (39.3) | 0.023a,3; 0.002a,3; < 0.001a,3 |
HTN | 15 (17.9) | 34 (40.0) | ||
Obesity | 3 (3.6) | 42 (49.4) | ||
weight Z-score (SD) | mean ± SD | 0.12 ± 0.72 | 2.32 ± 0.28 | < 0.001a,3 |
Median [IQR] | 0.29 [-0.33 to 0.70] | 2.30 [2.10 to 2.42] | ||
Height Z-score (SD) | mean ± SD | -0.05 ± 0.76 | 0.78 ± 0.66 | < 0.001a,3 |
Median [IQR] | -0.14 [-0.65 to 0.36] | 0.62 [0.24 to 1.40] | ||
BMI (kg/m2) | mean ± SD | 18.00 ± 2.60 | 28.32 ± 3.51 | < 0.001a,3 |
Median [IQR] | 17.80 [16.00-19.50] | 28.40 [25.80-30.50] | ||
BMI Z-score (SD) | mean ± SD | 0.22 ± 0.78 | 2.24 ± 0.19 | < 0.001a,3 |
Median [IQR] | 0.36 [0.00-0.82] | 2.20 [2.10-2.36] | ||
Waist circumference (cm) | mean ± SD | 60.44 ± 3.86 | 88.08 ± 8.71 | < 0.001a,3 |
Median [IQR] | 60.00 [57.50-62.00] | 86.00 [81.00-94.00] | ||
Waist circumference (centile) | mean ± SD | 38.36 ± 13.27 | 96.45 ± 2.31 | < 0.001a,3 |
Median [IQR] | 43.00 [26.30-49.10] | 97.00 [95.80-98.00] | ||
W/H ratio | mean ± SD | 0.43 ± 0.02 | 0.60 ± 0.04 | < 0.001a,3 |
Median [IQR] | 0.43 [0.41-0.44] | 0.60 [0.57-0.63] | ||
W/H ratio (centile) | mean ± SD | 33.27 ± 15.93 | 95.39 ± 3.38 | < 0.001a,3 |
Median [IQR] | 30.80 [18.70-50.00] | 96.00 [93.60-97.80] | ||
SBP (centile) | mean ± SD | 51.76 ± 13.95 | 54.89 ± 18.98 | 0.2003 |
Median [IQR] | 51.00 [46.00-58.00] | 55.00 [49.00-61.00] | ||
DBP (centile) | mean ± SD | 53.72 ± 13.45 | 54.36 ± 14.80 | 1.0003 |
Median [IQR] | 47.00 [43.00-59.00] | 51.00 [48.00-66.00] | ||
ALT (U/L) | mean ± SD | 24.44 ± 3.54 | 24.75 ± 7.68 | 1.0003 |
Median [IQR] | 26.00 [22.00-27.00] | 24.00 [22.00-26.00] | ||
AST (U/L) | mean ± SD | 22.42 ± 4.20 | 23.20 ± 5.65 | 0.3003 |
Median [IQR] | 22.00 [18.00-26.00] | 22.00 [19.00-26.00] | ||
Total cholesterol (mg/dL) | mean ± SD | 145.91 ± 14.21 | 156.86 ± 23.93 | < 0.001a,3 |
Median [IQR] | 146.00 [138.00-159.00] | 151.00 [143.00-165.00] | ||
HDL-C (mg/dL) | mean ± SD | 48.25 ± 3.88 | 40.66 ± 3.03 | < 0.001a,3 |
Median [IQR] | 47.00 [45.00-50.00] | 42.00 [40.00-42.00] | ||
LDL-C (mg/dL) | mean ± SD | 92.71 ± 11.60 | 101.12 ± 19.68 | 0.001a,3 |
Median [IQR] | 94.00 [82.00-104.00] | 91.00 [85.00-110.00] | ||
Triglycerides (mg/dL) | mean ± SD | 75.65 ± 16.95 | 109.12 ± 28.24 | < 0.001a,3 |
Median [IQR] | 73.00 [60.00-89.00] | 103.00 [89.00-115.00] | ||
VAI | mean ± SD | 0.94 ± 0.22 | 1.70 ± 0.57 | < 0.001a,3 |
Median [IQR] | 1.01 [0.76-1.05] | 1.63 [1.11-2.20] | ||
Serum insulin (uIU/mL) | mean ± SD | 8.05 ± 2.09 | 17.23 ± 7.50 | < 0.001a,3 |
Median [IQR] | 8.00 [6.20-8.90] | 17.20 [11.60-19.70] | ||
FBS (mg/dL) | mean ± SD | 72.04 ± 6.97 | 81.37 ± 15.21 | < 0.001a,3 |
Median [IQR] | 71.00 [68.00-74.00] | 80.00 [70.00- 5.00] | ||
HOMA-IR | mean ± SD | 1.42 ± 0.42 | 3.51 ± 1.85 | < 0.001a,3 |
Median [IQR] | 1.40 [1.20-1.60] | 3.50 [2.10-4.00] | ||
SEPP1 (ng/mL) | mean ± SD | 70.97 ± 6.49 | 12.12 ± 10.92 | < 0.001a,3 |
Median [IQR] | 69.47 [65.89-77.42] | 7.69 [5.82-13.99] | ||
Insulin resistance | Present | 5 (5.9) | 39 (45.9) | < 0.001a,3 |
Absent | 80 (94.1) | 46 (54.1) |
Table 2 Correlations of serum selenoprotein P1 in children with obesity
SEPP1 (ng/mL), children with obesity | ||
rs | P value | |
Age of enrolment (years) | -0.098 | 0.371 |
weight Z score (SD) | -0.001 | 0.995 |
Height Z score (SD) | 0.042 | 0.701 |
BMI (kg/m2) | -0.338 | 0.002a |
BMI Z score (SD) | -0.044 | 0.686 |
Waist circumference (cm) | -0.527 | < 0.001a |
Waist circumference (centile) | -0.183 | 0.094 |
W/H ratio | -0.394 | < 0.001a |
W/H ratio (centile) | -0.279 | 0.010a |
ALT (U/L) | -0.240 | 0.027a |
AST (U/L) | -0.219 | 0.044a |
Total cholesterol (mg/dL) | -0.185 | 0.089 |
HDL (mg/dL) | 0.084 | 0.443 |
LDL (mg/dL) | 0.076 | 0.491 |
Triglycerides (mg/dL) | -0.012 | 0.916 |
VAI | -0.252 | 0.020a |
Serum insulin (uIU/mL) | -0.223 | 0.040a |
FBS mg/dL | -0.258 | 0.017a |
HOMA-IR | -0.279 | 0.010a |
Table 3 Selenoprotein P1 level in Insulin and non-insulin resistant children with obesity based on Homeostatic Model Assessment of Insulin Resistance[15]
Table 4 Predictive/diagnostic performance of selenoprotien P1 from receiver operating characteristic curve analysis
Obesity children | |
AUC | 0.828 |
SE | 0.053 |
95%CI | 0.724-0.931 |
P value | < 0.0001a |
Cut-off value | ≤ 7.5 |
Sensitivity (%) | 92.31 |
Specificity (%) | 86.96 |
PPV (%) | 85.7 |
NPV (%) | 93.0 |
Table 5 Univariate and multivariate logistic regression analysis for variables affecting insulin resistance in the obese group
Independent variables | Univariate regression | Multivariate regression | ||||
P value | OR | 95%CI for OR | P value | OR | 95%CI for OR | |
Sex (Male) | 0.018a | 0.399 | 0.186-0.855 | 0.106 | 0.384 | 0.120-1.224 |
Age of enrolment (years) | 0.046a | 1.170 | 1.003-1.366 | 0.025a | 1.355 | 1.038-1.767 |
Waist circumference (centile) | 0.034a | 1.150 | 1.010-1.309 | _ | _ | _ |
W/H ratio (centile) | 0.013a | 1.154 | 1.031-1.292 | _ | _ | _ |
BMI Z score (SD) | 0.001a | 18.684 | 4.415-79.071 | 0.101 | 13.458 | 0.600-301.944 |
SEEP1 (ng/mL) | 0.002a | 0.837 | 0.746-0.938 | 0.007a | 0.880 | 0.803-0.966 |
Table 6 Multiple linear regression analysis for factors affecting selenoprotien P1 level in children with obesity (n = 85)
Variables1 | B | 95%CI | P value |
DBP | -0.571 | -1.313 to 0.171 | 0.129 |
Height (cm) | 0.077 | -2.640 to 2.794 | 0.955 |
Waist circumference (cm) | 0.414 | -4.348 to 5.176 | 0.863 |
BMI (kg/m2) | -0.542 | -1.726 to 0.643 | 0.365 |
W/H ratio | 33.413 | -631.753 to 698.579 | 0.920 |
ALT (U/L) | -0.100 | -0.467 to 0.267 | 0.589 |
AST (U/L) | -0.470 | -1.005 to 0.066 | 0.085 |
Total Cholesterol (mg/dL) | -0.321 | -0.526 to -0.117 | 0.003a |
HDL (mg/dL) | -0.893 | -1.835 to 0.049 | 0.063 |
LDL (mg/dL) | 0.335 | 0.089 to 0.581 | 0.008a |
Triglycerides (mg/dL) | 0.163 | 0.016 to 0.309 | 0.030a |
VAI | -8.340 | -15.321 to -1.359 | 0.020a |
Serum insulin (uIU/mL) | 1.295 | 0.443 to 2.146 | 0.003a |
HOMA-IR | -6.224 | -9.685 to -2.764 | 0.001a |
- Citation: Elbarky A, Ismail KG, Yousef YF, Elshafiey RMG, Elsharaby RM, El-Kaffas A, Al-Beltagi M. Selenoprotein-p and insulin resistance in children and adolescents with obesity. World J Clin Pediatr 2024; 13(3): 94721
- URL: https://www.wjgnet.com/2219-2808/full/v13/i3/94721.htm
- DOI: https://dx.doi.org/10.5409/wjcp.v13.i3.94721