Elbarky A, Ismail KG, Yousef YF, Elshafiey RMG, Elsharaby RM, El-Kaffas A, Al-Beltagi M. Selenoprotein-p and insulin resistance in children and adolescents with obesity. World J Clin Pediatr 2024; 13(3): 94721 [PMID: 39350909 DOI: 10.5409/wjcp.v13.i3.94721]
Corresponding Author of This Article
Mohammed Al-Beltagi, MBChB, MD, PhD, Academic Editor, Chairman, Full Professor, Research Scientist, Department of Pediatric, Faculty of Medicine, Tanta University, Al-Bahr Street, The Medical Complex, Tanta 31511, Alghrabia, Egypt. mbelrem@hotmail.com
Research Domain of This Article
Nutrition & Dietetics
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Amany Elbarky, Yousef Fouad Yousef, Rasha Mohamed Gamal Elshafiey, Gastroenterology and Clinical Nutrition Unit, Pediatric Department, Faculty of Medicine, Tanta University, Tanta 31511, Alghrabia, Egypt
Kholoud Gamal Ismail, Asmaa El-Kaffas, Mohammed Al-Beltagi, Department of Pediatric, Faculty of Medicine, Tanta University, Tanta 31511, Alghrabia, Egypt
Radwa Mahmoud Elsharaby, Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta 31511, Alghrabia, Egypt
Mohammed Al-Beltagi, Department of Paediatric, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Manama 26671, Manama, Bahrain
Author contributions: Elbarky A, Ismail KG, Yousef YF, El Shafiey RMG, Elsharaby RM, Elkafas A, and Al-Beltagi M were all actively involved in collecting data for this study; They also collaborated in writing and revising the manuscript; Each author contributed to the critical revision of the content, ensuring accuracy and coherence throughout the manuscript; All authors reviewed and approved the final version, demonstrating their collective agreement and commitment to the research findings presented in this study.
Institutional review board statement: This study was conducted in accordance with the guidelines of the Declaration of Helsinki and approved by the Ethical and Research Committee of the Faculty of Medicine, Tanta University, Egypt.
Informed consent statement: Written informed consent was obtained from parents or caregivers before enrolling their children in the study.
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request.
STROBE statement: The study was done according to and aligned with the STROBE guidelines, and detailed observational study reporting was ensured. The STROBE checklist is attached.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammed Al-Beltagi, MBChB, MD, PhD, Academic Editor, Chairman, Full Professor, Research Scientist, Department of Pediatric, Faculty of Medicine, Tanta University, Al-Bahr Street, The Medical Complex, Tanta 31511, Alghrabia, Egypt. mbelrem@hotmail.com
Received: March 23, 2024 Revised: June 28, 2024 Accepted: July 10, 2024 Published online: September 9, 2024 Processing time: 159 Days and 7.6 Hours
Core Tip
Core Tip: This study investigates the association between serum Selenoprotein P1 (SEPP1) levels and insulin resistance in pediatric obesity. Conducted on 170 children, the study reveals significantly lower SEPP1 levels in obese children compared to healthy peers, with notable negative correlations between SEPP1 levels and adiposity indices such as body mass index, visceral adiposity index, and Homeostatic Model Assessment of Insulin Resistance. The findings suggest SEPP1's potential as a predictor for insulin resistance in pediatric obesity, highlighting its utility in metabolic health assessment. However, further research is needed to determine the temporal relationship between SEPP1 levels and insulin resistance onset in pediatric obesity, emphasizing the importance of continued investigation in this area for clinical practice.
