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World J Clin Pediatr. Feb 8, 2016; 5(1): 67-74
Published online Feb 8, 2016. doi: 10.5409/wjcp.v5.i1.67
Short and long term prognosis in perinatal asphyxia: An update
Caroline E Ahearne, Geraldine B Boylan, Deirdre M Murray
Caroline E Ahearne, Geraldine B Boylan, Deirdre M Murray, Department of Paediatrics and Child Health, University College Cork, Cork T12 YN60, Ireland
Caroline E Ahearne, Geraldine B Boylan, Deirdre M Murray, Irish Centre for Fetal and Neonatal Translational Research (INFANT Centre), University College Cork, Cork T12 YN60, Ireland
Author contributions: Ahearne CE aided in the literature review, and contributed to the text and preparation of the manuscript; Boylan GB contributed to the manuscript and edited final content; Murray DM wrote and edited the manuscript.
Supported by The Health Research Board CSA/2012/40; and a Science Foundation Ireland Research Centre Award (INFANT - 12/RC/2272).
Conflict-of-interest statement: There is no conflict of interest associated with either of the authors who contributed to this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Deirdre Murray, Department of Paediatrics and Child Health, University College Cork, Western Rd, Cork T12 YN60, Ireland. d.murray@ucc.ie
Telephone: +353-21-4205023
Received: July 31, 2015
Peer-review started: August 3, 2015
First decision: October 13, 2015
Revised: November 18, 2015
Accepted: December 17, 2015
Article in press: December 18, 2015
Published online: February 8, 2016
Processing time: 180 Days and 22 Hours
Core Tip

Core tip: Perinatal asphyxia is a significant cause of acquired brain injury occurring in the neonatal period. A reliable early marker for predicting injury severity and sequelae remains elusive. The advent of therapeutic hypothermia as an effective neuroprotective intervention has changed the prognosis for affected infants. In this review we summarise what is known about the short and long term outcome for infants with perinatal asphyxia in the pre- and post-cooling era. We also describe currently available early indicators of outcome and introduce the exciting field of emerging novel biomarkers, both chemical and physiological.