©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Feb 8, 2016; 5(1): 67-74
Published online Feb 8, 2016. doi: 10.5409/wjcp.v5.i1.67
Published online Feb 8, 2016. doi: 10.5409/wjcp.v5.i1.67
Short and long term prognosis in perinatal asphyxia: An update
Caroline E Ahearne, Geraldine B Boylan, Deirdre M Murray, Department of Paediatrics and Child Health, University College Cork, Cork T12 YN60, Ireland
Caroline E Ahearne, Geraldine B Boylan, Deirdre M Murray, Irish Centre for Fetal and Neonatal Translational Research (INFANT Centre), University College Cork, Cork T12 YN60, Ireland
Author contributions: Ahearne CE aided in the literature review, and contributed to the text and preparation of the manuscript; Boylan GB contributed to the manuscript and edited final content; Murray DM wrote and edited the manuscript.
Supported by The Health Research Board CSA/2012/40; and a Science Foundation Ireland Research Centre Award (INFANT - 12/RC/2272).
Conflict-of-interest statement: There is no conflict of interest associated with either of the authors who contributed to this manuscript.
Correspondence to: Dr. Deirdre Murray, Department of Paediatrics and Child Health, University College Cork, Western Rd, Cork T12 YN60, Ireland. d.murray@ucc.ie
Telephone: +353-21-4205023
Received: July 31, 2015
Peer-review started: August 3, 2015
First decision: October 13, 2015
Revised: November 18, 2015
Accepted: December 17, 2015
Article in press: December 18, 2015
Published online: February 8, 2016
Processing time: 180 Days and 22 Hours
Peer-review started: August 3, 2015
First decision: October 13, 2015
Revised: November 18, 2015
Accepted: December 17, 2015
Article in press: December 18, 2015
Published online: February 8, 2016
Processing time: 180 Days and 22 Hours
Core Tip
Core tip: Perinatal asphyxia is a significant cause of acquired brain injury occurring in the neonatal period. A reliable early marker for predicting injury severity and sequelae remains elusive. The advent of therapeutic hypothermia as an effective neuroprotective intervention has changed the prognosis for affected infants. In this review we summarise what is known about the short and long term outcome for infants with perinatal asphyxia in the pre- and post-cooling era. We also describe currently available early indicators of outcome and introduce the exciting field of emerging novel biomarkers, both chemical and physiological.