Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Nov 8, 2015; 4(4): 106-112
Published online Nov 8, 2015. doi: 10.5409/wjcp.v4.i4.106
Published online Nov 8, 2015. doi: 10.5409/wjcp.v4.i4.106
Fever tree revisited: From malaria to autoinflammatory diseases
Serena Pastore, Andrea Taddio, Alberto Tommasini, Department of Pediatrics, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy
Josef Vuch, Andrea Taddio, Department of Medical Surgical and Health Sciences, University of Trieste, 34137 Trieste, Italy
Anna Monica Bianco, Department of Laboratory, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy
Author contributions: Pastore S drafted the manuscript; Vuch J critically revised the manuscript; Bianco AM critically revised the biological and genetic content of the manuscript; Taddio A designed and discussed the article; Tommasini A designed the article and approved the final version of the article to be published.
Conflict-of-interest statement: The authors declare no conflict of interest relevant to this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alberto Tommasini, MD, PhD, Department of Pediatrics, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34137 Trieste, Italy. alberto.tommasini@burlo.trieste.it
Telephone: +39-40-3785422
Received: January 22, 2015
Peer-review started: February 1, 2015
First decision: March 6, 2015
Revised: March 20, 2015
Accepted: September 7, 2015
Article in press: September 8, 2015
Published online: November 8, 2015
Processing time: 291 Days and 15.9 Hours
Peer-review started: February 1, 2015
First decision: March 6, 2015
Revised: March 20, 2015
Accepted: September 7, 2015
Article in press: September 8, 2015
Published online: November 8, 2015
Processing time: 291 Days and 15.9 Hours
Core Tip
Core tip: Periodic fevers of autoinflammatory nature have been increasingly recognized in recent decades, in many cases reflecting monogenic disorders of inflammation. However, patients can be encountered in clinical practice who don’t fit in any definite category of periodic fever, despite of extensive molecular analyses. A clinical approach based on the analogy with the well defined monogenic diseases can be reasonable in these cases, which likely represent an heterogeneous group of multifactorial disorders. We propose revising the historical image of the fever tree to figure the possible existence of a disease continuum between multifactorial and monogenic periodic fever syndromes.