Association of Helicobacter pylori infection with insulin resistance, tumor necrosis factor-alpha, and dyslipidemia in obese children with metabolic syndrome

doi:10.5409/wjcp.v15.i3.121926

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Sep 9, 2026; 15(3): 121926
Published online Sep 9, 2026. doi: 10.5409/wjcp.v15.i3.121926

Association of Helicobacter pylori infection with insulin resistance, tumor necrosis factor-alpha, and dyslipidemia in obese children with metabolic syndrome

Noura M Ibrahim Elbakry, Mohamed S Hemeda, Ayat Mostafa Mohamed Ahmed, Hager Adel Zaky, Aya Nabil Gamil, Abd Elmoaty Arafat Abd Elmoaty, Mahmoud M Khafagi, Ashraf Mohamed Alkabeer, Aldosoky Abd Elaziz Alsaid, Ahmed A Elhagary, Walid Mohammed Aboassy, Ahmed Nabil Gamil Mohammed

Noura M Ibrahim Elbakry, Ahmed Nabil Gamil Mohammed, Department of Pediatric, Faculty of Medicine, Minia University, Minia 2422998, Egypt

Mohamed S Hemeda, Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Port Said University, Port Said 44654, Egypt

Ayat Mostafa Mohamed Ahmed, Department of Clinical Pathology and Chemistry, Faculty of Medicine, Minia University, Minia 2422998, Egypt

Hager Adel Zaky, Department of Public Health, Faculty of Medicine, Faculty of Medicine, Minia University, Minia 2422998, Egypt

Aya Nabil Gamil, Department of Microbiology and Immunology, Minia University, Minia 45638, Egypt

Abd Elmoaty Arafat Abd Elmoaty, Mahmoud M Khafagi, Department of Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Assiut 44654, Egypt

Ashraf Mohamed Alkabeer, Aldosoky Abd Elaziz Alsaid, Ahmed A Elhagary, Department of Internal Medicine, Al-Azhar University, Assiut 2422998, Egypt

Walid Mohammed Aboassy, Pediatric Faculty of Medicine Port Said University, Port Said 42526, Egypt

Author contributions: Elbakry NMI, Hemeda MS, Aboassy WM, and Ahmed AMM conceptualized and designed the study; Elbakry NMI, Mohammed ANG, and Gamil AN recruited participants and collected the data; Ahmed AMM, Zaky HA, and Gamil AN performed the laboratory investigations and analytical procedures; Abd Elmoaty AAA, Khafagi MM, Alkabeer AM, Alsaid AAE, and Elhagary AA contributed to clinical assessment and data interpretation; Hemeda MS and Zaky HA performed the statistical analysis and critically revised the manuscript; Mohammed ANG drafted the initial manuscript; all authors reviewed the final version of the manuscript, approved it for publication, and agreed to be accountable for all aspects of the work.

Institutional review board statement: The study protocol was reviewed and approved by the Institutional Review Board of the Faculty of Medicine, Minia University (MUFMIRB) (Approval No. 92-23/6/2023; June 12, 2023).

Informed consent statement: Written informed consent was obtained from the parents or legal guardians of all participants, and assent was obtained from children whenever applicable, in accordance with the Declaration of Helsinki.

Conflict-of-interest statement: All the authors declare that they have no conflict of interest related to this study.

STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.

Data sharing statement: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

Corresponding author: Mohamed S Hemeda MD, Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Port Said University, Port Said 44654, Egypt. mohamudsadawy@med.psu.edu.eg

Received: April 7, 2026
Revised: April 20, 2026
Accepted: May 6, 2026
Published online: September 9, 2026
Processing time: 117 Days and 17.1 Hours

Core Tip

Core Tip: In obese children and adolescents with a metabolic syndrome phenotype, Helicobacter pylori (H. pylori) positivity was associated with higher homeostasis model assessment of insulin resistance, higher tumor necrosis factor-alpha, a more atherogenic lipid profile, elevated liver enzymes, hepatomegaly, and higher rates of elevated blood pressure. Several associations remained significant after adjustment for age, sex, and standardized body mass index value. These findings suggest that H. pylori positivity may mark a greater inflammatory and metabolic burden in high-risk pediatric obesity, while causality still requires confirmation in prospective studies.