Subramaniam P, Jacob N, Saravanan VR, Shah PK, Das A, Venkatapathy N. Autologous in vitreo generated plasmin assisted vitrectomy in the pediatric population. World J Clin Pediatr 2026; 15(3): 120868 [DOI: 10.5409/wjcp.120868]
Corresponding Author of This Article
Parag K Shah, Professor, Department of Pediatric Retina and Ocular Oncology, Postgraduate Institute of Ophthalmology, Aravind Eye Hospital, Avinashi Road, Coimbatore 641014, Tamil Nādu, India. drshahpk2002@yahoo.com
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Ophthalmology
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research-article
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Subramaniam P, Jacob N, Saravanan VR, Shah PK, Das A, Venkatapathy N. Autologous in vitreo generated plasmin assisted vitrectomy in the pediatric population. World J Clin Pediatr 2026; 15(3): 120868 [DOI: 10.5409/wjcp.120868]
World J Clin Pediatr. Sep 9, 2026; 15(3): 120868 Published online Sep 9, 2026. doi: 10.5409/wjcp.120868
Autologous in vitreo generated plasmin assisted vitrectomy in the pediatric population
Prema Subramaniam, Ninan Jacob, Veerappan Rathinasabapathy Saravanan, Parag K Shah, Abhishek Das, Narendran Venkatapathy
Prema Subramaniam, Parag K Shah, Abhishek Das, Narendran Venkatapathy, Department of Pediatric Retina and Ocular Oncology, Postgraduate Institute of Ophthalmology, Aravind Eye Hospital, Coimbatore 641014, Tamil Nādu, India
Ninan Jacob, Department of Pediatric Retina and Ocular Oncology, Aravind Eye Hospital & Post Graduate Institute of Ophthalmology, Coimbatore 641004, Tamil Nādu, India
Veerappan Rathinasabapathy Saravanan, Department of Vitreoretina, Aravind Eye Hospital, Coimbatore 641014, Tamil Nādu, India
Co-first authors: Prema Subramaniam and Ninan Jacob.
Author contributions: Subramaniam P, Saravanan VR, Shah PK, Venkatapathy N designed the research; Subramaninam P, Saravanan VR, Jacob N, Das A performed the research. Subramaniam P and Jacob N contributed equally to this work as co-first authors.
Institutional review board statement: The study was reviewed and approved by the Institutional review board of Aravind Eye Hospital, Madurai Institutional Review Board, No. RET202200528.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: No conflicts of interest.
Data sharing statement: Participants gave informed consent for data sharing.
Corresponding author: Parag K Shah, Professor, Department of Pediatric Retina and Ocular Oncology, Postgraduate Institute of Ophthalmology, Aravind Eye Hospital, Avinashi Road, Coimbatore 641014, Tamil Nādu, India. drshahpk2002@yahoo.com
Received: March 11, 2026 Revised: April 17, 2026 Accepted: June 22, 2026 Published online: September 9, 2026 Processing time: 145 Days and 11.1 Hours
Core Tip
Core Tip: Posterior vitreous detachment (PVD), a key to the success in all vitreoretinal surgeries, is a crucial and challenging step in pediatric vitreoretinal surgeries especially syndromic retinal detachments. Surgical success is not fruitful even in experienced hands. The use of enzymatic vitreolysis (with plasmin) is promising in PVD induction, but unfortunately its usage is restricted due to the limitation in procuring these less durable enzymes. This method of in vivo plasmin generation by injecting a readily available agent (autologous whole blood) and tissue plasminogen activator yields plasmin inside the vitreous cavity and help in PVD induction henceforth surgical success. This retrospective pilot study will be beneficial for practicing vitreoretinal surgeons.
