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World J Clin Pediatr. Sep 9, 2026; 15(3): 119602
Published online Sep 9, 2026. doi: 10.5409/wjcp.119602
Published online Sep 9, 2026. doi: 10.5409/wjcp.119602
Clinical recovery of severe infantile Angiostrongylus cantonensis meningoencephalomyelitis treated with pulse methylprednisolone: A case report and review of literature
Bao Trung Nguyen, Luan Thanh Vo, Tuong Trong-Hanh Tran, Viet Chau Do, Thanh Tat Nguyen, Department of Infectious Diseases, Children’s Hospital 2, Ho Chi Minh City 700000, Viet Nam
Uyen Hai Pham, Department of Neurology, Children’s Hospital 2, Ho Chi Minh City 700000, Viet Nam
Hung Nam Tran, Department of Diagnostic Imaging, Children’s Hospital 2, Ho Chi Minh City 700000, Viet Nam
Oanh Hoang-Tran Dang, Department of Nutrition, Children’s Hospital 2, Ho Chi Minh City 700000, Viet Nam
Dat Tat Nguyen, Department of Clinical Pharmacy, American International Hospital, Ho Chi Minh City 700000, Viet Nam
Lien Thi To, Faculty of Nursing, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Viet Nam
Co-first authors: Bao Trung Nguyen and Luan Thanh Vo.
Author contributions: Nguyen BT and Vo LT were responsible for the clinical management of the patient and drafted the manuscript; Pham UH provided neurological consultation and follow-up assessments; Tran HN performed and interpreted the neuroimaging studies; Nguyen DT, Tran TTH, To LT, and Do VC contributed to data collection and literature review; Dang OHT coordinated nutritional support during hospitalization; Nguyen TT supervised the clinical care, critically revised the manuscript, and approved the final version; and all authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Thanh Tat Nguyen, MD, PhD, Senior Researcher, Department of Infectious Diseases, Children’s Hospital 2, Ly Tu Trong, Ho Chi Minh City 700000, Viet Nam. thanhhonor@gmail.com
Received: February 2, 2026
Revised: March 6, 2026
Accepted: March 23, 2026
Published online: September 9, 2026
Processing time: 181 Days and 9.7 Hours
Revised: March 6, 2026
Accepted: March 23, 2026
Published online: September 9, 2026
Processing time: 181 Days and 9.7 Hours
Core Tip
Core Tip: Angiostrongylus cantonensis meningoencephalomyelitis in infants is rare and often fatal. We report a case of a 10-month-old infant with deep coma, flaccid quadriplegia, and neurogenic shock who achieved near-complete neurological recovery. Early administration of pulse methylprednisolone (30 mg/kg/day for 5 days) combined with albendazole was associated with a favorable outcome. This case supports the early use of high-dose pulse corticosteroid therapy to attenuate inflammatory neurological injury and improve the prognosis in critically ill infants with severe eosinophilic meningoencephalomyelitis.