Persistent long-term subclinical myocardial changes in multisystem inflammatory syndrome in children revealed by cardiac magnetic resonance and galectin-3

doi:10.5409/wjcp.118237

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 15, Issue 3

This Article

(2)

(1)

(0)

(23)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Clinical Pediatrics

ISSN

2219-2808

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Sep 9, 2026; 15(3): 118237
Published online Sep 9, 2026. doi: 10.5409/wjcp.118237

Persistent long-term subclinical myocardial changes in multisystem inflammatory syndrome in children revealed by cardiac magnetic resonance and galectin-3

Sathish K OV, Rakesh K Pilania, Radhika Semwal, Gopika Sri, Taranpreet Kaur, Pavithra Subramanian, Ankur Jindal, Sanjeev Naganur, Surjit Singh, Manphool Singhal

Sathish K OV, Rakesh K Pilania, Radhika Semwal, Ankur Jindal, Surjit Singh, Pediatric Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, Chandīgarh, India

Gopika Sri, Taranpreet Kaur, Pavithra Subramanian, Manphool Singhal, Department of Radio Diagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, Chandīgarh, India

Sanjeev Naganur, Department of Cardiology, Advanced Cardiac Centre, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, Chandīgarh, India

Co-corresponding authors: Rakesh K Pilania and Manphool Singhal.

Author contributions: OV SK, Pilania RK, Semwal R, and Singhal M designed and conducted the study and wrote the paper; Sri G, Kaur T, Subramanian P, and Singhal M contributed to the analysis; Jindal A and Naganur S provided clinical advice; and Pilania RK, Singh S, and Singhal M supervised the study; Pilania RK and Singhal M they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.

Supported by the Indian Council of Medical Research, Department of Health Research, Ministry of Health and Family Welfare, Government of India, New Delhi, No. 3/2/MD thesis-June-2022/IH&HRD/2022.

Institutional review board statement: This study was approved by the Medical Ethics Committee of Postgraduate Institute of Medical Education and Research, approval No. INT/IEC/2022/MD-454.

Informed consent statement: Informed consent and assent were obtained from parents and patients, respectively.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.

Data sharing statement: The data underlying this article are available in the manuscript and our records. These data can be shared on request.

Corresponding author: Rakesh K Pilania, Associate Professor, Pediatric Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, APC 4A, 4127, Advanced Pediatrics, Pgimer, Chandigarh 160012, Chandīgarh, India. kumarpilania007@gmail.com

Received: December 29, 2025
Revised: February 21, 2026
Accepted: April 7, 2026
Published online: September 9, 2026
Processing time: 215 Days and 4 Hours

Core Tip

Core Tip: Children recovering from multisystem inflammatory syndrome in children may appear to have complete cardiac recovery on routine echocardiography, yet subtle myocardial abnormalities can persist undetected. Cardiac magnetic resonance imaging performed nearly two years post-illness revealed reduced ejection fraction and elevated native T1 values in a subset of patients, suggesting subclinical myocardial dysfunction. Although serum galectin-3 levels were mildly elevated, they did not correlate with imaging markers. These findings highlight the importance of incorporating cardiac magnetic resonance imaging into long-term follow-up to identify silent myocardial changes and guide future surveillance strategies in multisystem inflammatory syndrome in children survivors.