Wan-Nik FH, Zulkeflee HA, Ab Rahim NS, Tuan-Ismail ST. Rare coexistence of aldosterone resistance and adrenal insufficiency in asymptomatic infant with persistent hyperkalaemia: A case report. World J Clin Pediatr 2026; 15(2): 113666 [DOI: 10.5409/wjcp.v15.i2.113666]
Corresponding Author of This Article
Salwani T Tuan-Ismail, Associate Professor, Endocrinology Unit, Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia. tusti@usm.my
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Endocrinology & Metabolism
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Case Report
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Jun 9, 2026 (publication date) through May 16, 2026
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World Journal of Clinical Pediatrics
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2219-2808
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Wan-Nik FH, Zulkeflee HA, Ab Rahim NS, Tuan-Ismail ST. Rare coexistence of aldosterone resistance and adrenal insufficiency in asymptomatic infant with persistent hyperkalaemia: A case report. World J Clin Pediatr 2026; 15(2): 113666 [DOI: 10.5409/wjcp.v15.i2.113666]
World J Clin Pediatr. Jun 9, 2026; 15(2): 113666 Published online Jun 9, 2026. doi: 10.5409/wjcp.v15.i2.113666
Rare coexistence of aldosterone resistance and adrenal insufficiency in asymptomatic infant with persistent hyperkalaemia: A case report
Fazila H Wan-Nik, Hani A Zulkeflee, Nadirah S Ab Rahim, Salwani T Tuan-Ismail
Fazila H Wan-Nik, Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia
Hani A Zulkeflee, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Bandar Baru Nilai, Nilai 71800, Negeri Sembilan, Malaysia
Nadirah S Ab Rahim, Pathology Unit, Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kem Perdana Sungai Besi 57000, Kuala Lumpur, Malaysia
Salwani T Tuan-Ismail, Endocrinology Unit, Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia
Author contributions: Wan-Nik FH, Zulkeflee HA, Ab Rahim SN contributed to manuscript writing and editing, Tuan-Ismail ST contributed to conceptualization and supervision; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Salwani T Tuan-Ismail, Associate Professor, Endocrinology Unit, Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia. tusti@usm.my
Received: September 1, 2025 Revised: November 2, 2025 Accepted: January 9, 2026 Published online: June 9, 2026 Processing time: 255 Days and 7 Hours
Core Tip
Core Tip: A 6-month-old male was incidentally found to have persistent hyperkalaemia despite being asymptomatic with normal electrocardiogram documented during hospitalization for bronchiolitis. Laboratory evaluation showed elevated serum aldosterone, suppressed plasma renin activity, normal serum sodium and chloride with low serum bicarbonate, consistent with aldosterone resistance. Additionally, a short synacthen test confirmed adrenal insufficiency, with normal serum 17-hydroxyprogesterone excluding (congenital adrenal hyperplasia). He required escalating fludrocortisone alongside hydrocortisone and potassium binders, indicating mineralocorticoid resistance. Genetic testing was not performed, but clinical and biochemical findings strongly support coexisting aldosterone resistance and adrenal insufficiency; an exceptionally rare dual endocrinopathy.
