Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Clin Pediatr. Jun 9, 2026; 15(2): 112551
Published online Jun 9, 2026. doi: 10.5409/wjcp.v15.i2.112551
Published online Jun 9, 2026. doi: 10.5409/wjcp.v15.i2.112551
Study of the gut microbiome profile in full-term infants with necrotizing enterocolits
Eman Hamza Hassan, Wessam Zaghloul, Department of Pediatrics, Faculty of Medicine Alexandria University, Alexandria 21526, Egypt
Shwikar Mahmoud Ahmed, Department of Medical Microbiology and Immunology, Faculty of Medicine Alexandria University, Alexandria 21526, Egypt
Ahmed M Ghozi, Department of Clinical Pharmacy, Pediatric Surgery and Internal Medicine Units, Alexandria 21526, Egypt
Ibrahim A Abdelwahab, Department of Microbiology and Immunology, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria 21648, Egypt
Author contributions: Hassan EH obtained ethical approval, and was major contributor to the writing of the manuscript; Zaghloul W analyzed and interpreted the data from cases and controls regarding necrotizing enterocolitis disease; Ahmed SM performed the laboratory examination of stool samples via real-time polymerase chain reaction and reported the individual case results; Ghozi AM was responsible data collection, as well as for collecting and transporting stool samples; Abdelwahab IA conceptualized and designed the study, supervised the research process, and critically reviewed and revised the manuscript for important intellectual content. All authors have read and approved the final manuscript.
Institutional review board statement: Ethical approval was obtained from the Local Ethical Committee, Faculty of Medicine, Alexandria University (IRB No. 00012098).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: All the data generated or analyzed during this study are included in this published article. The underlying datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Corresponding author: Wessam Zaghloul, MD, PhD, Department of Pediatrics, Faculty of Medicine Alexandria University, 22 El-Guish Road, El-Shatby, Alexandria 21526, Egypt.
Received: July 31, 2025
Revised: September 10, 2025
Accepted: December 23, 2025
Published online: June 9, 2026
Processing time: 287 Days and 4.9 Hours
Revised: September 10, 2025
Accepted: December 23, 2025
Published online: June 9, 2026
Processing time: 287 Days and 4.9 Hours
Core Tip
Core Tip: The study aims to map the gut microbiome profile of full-term infants with non-Hirschsprung’s [necrotizing enterocolitis (NEC)] in Egypt and to relate the gut microbiome profile of non-Hirschsprung’s NEC in full-term infants to the source of the feeding factor. The study aims to compare the gut microbiome profile between NEC infants and healthy controls. The study was conducted in the Department of Pediatrics, Alexandria University.