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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Dec 9, 2025; 14(4): 110357
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.110357
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.110357
Uncovering hidden vitamin D deficiency in overweight children
Chandra Sekhar Devulapalli, Pediatric Outpatient Clinic, Department of Medicine, Helgeland Hospital, Alstahaug (Sandnessjøen) NO-8800, Nordland, Norway
Author contributions: Devulapalli CS conceptualized the study; curated the data; conducted the formal analyses and investigation; developed the methodology; gathered the resources; supervised the project; contributed to the validation of results and data visualization; and wrote, review, and edited the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chandra Sekhar Devulapalli, MD, PhD, Consultant, Senior Researcher, Senior Scientist, Pediatric Outpatient Clinic, Department of Medicine, Helgeland Hospital, Prestmarkveien 1, Alstahaug (Sandnessjøen) NO-8800, Nordland, Norway.
Received: June 5, 2025
Revised: June 13, 2025
Accepted: August 22, 2025
Published online: December 9, 2025
Processing time: 149 Days and 2.2 Hours
Revised: June 13, 2025
Accepted: August 22, 2025
Published online: December 9, 2025
Processing time: 149 Days and 2.2 Hours
Core Tip
Core Tip: This review challenges the conventional understanding of vitamin D deficiency in children with obesity by proposing a mechanistic framework that integrates adipose tissue dynamics, hepatic metabolism, and inflammatory signaling. It emphasizes that vitamin D status is not solely determined by intake or sun exposure, but rather results from complex physiological interactions. By highlighting the limitations of current diagnostic thresholds and supplementation strategies, the study advocates for a paradigm shift toward individualized, mechanism-based treatment approaches-an essential step to bridge the gap between biochemical adequacy and functional sufficiency in this vulnerable population.