Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Jun 9, 2025; 14(2): 103608
Published online Jun 9, 2025. doi: 10.5409/wjcp.v14.i2.103608
Disorders of gut-brain interaction are a new challenge of our increasingly complex society, with worldwide repercussions
Earl B Ettienne, Klaus Rose
Earl B Ettienne, College of Pharmacy, Howard University College of Pharmacy, Washington, DC 20059, United States
Klaus Rose, Pediatric Drug Development and More, Medical Science, Riehen CH-4125, Switzerland
Author contributions: Rose K provided a first draft; Ettienne EB revised and expanded the draft. Both authors worked jointly on the final version.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Klaus Rose, MD, Chief Physician, Pediatric Drug Development and More, Medical Science, Äussere Baselstrasse 308, Riehen CH-4125, Switzerland. klaus.rose@klausrose.net
Received: November 25, 2024
Revised: January 23, 2025
Accepted: February 14, 2025
Published online: June 9, 2025
Processing time: 113 Days and 15.8 Hours
Core Tip

Core Tip: Disorders of gut-brain interaction can seriously challenge patients‘ health and quality of life (QoL). This new approach no longer differentiates organic from functional (or psychiatric) disorders. This former, now outdated distinction did not help patients whose QoL was and is seriously impaired. Instead, todays symptom-based criteria attempts to better understand patients. The traditional explanations did not allow satisfying clinical treatment nor inclusion into exploratory trials with new drugs or biologics. With this new approach, the hope is to overcome the shortcomings of traditional approaches.