Prospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Mar 9, 2025; 14(1): 100453
Published online Mar 9, 2025. doi: 10.5409/wjcp.v14.i1.100453
Cardiovascular involvement in multisystem inflammatory syndrome in children and midterm follow-up from a pediatric tertiary center in India
Poovazhagi Varadarajan, Ritchie Sharon Solomon, Seenivasan Subramani, Ramesh Subramanian, Gomathy Srividya, Elilarasi Raghunathan
Poovazhagi Varadarajan, Seenivasan Subramani, Ramesh Subramanian, Gomathy Srividya, Department of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600003, Tamil Nādu, India
Ritchie Sharon Solomon, Department of Pediatric Cardiology, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600003, Tamil Nādu, India
Elilarasi Raghunathan, Department of Pediatrics, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600003, Tamil Nādu, India
Author contributions: Varadarajan P and Raghunathan E designed and conceptualized the study, analyzed data and edited the manuscript; Solomon RS contributed to the study design, analyzed the data and prepared the manuscript; Subramani S, Subramanian R and Srividhya G analyzed the data and revised the manuscript; all the authors have read, edited and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Madras Medical College, Institutional Review Board (Approval No. 44042020).
Clinical trial registration statement: Not applicable.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ritchie Sharon Solomon, DM, MBBS, MD, Assistant Professor, Department of Pediatric Cardiology, Institute of Child Health and Hospital for Children, Madras Medical College, Periyar Salai, Park Town, Chennai 600003, Tamil Nādu, India. ritchie_sharon@yahoo.com
Received: August 16, 2024
Revised: October 2, 2024
Accepted: October 30, 2024
Published online: March 9, 2025
Processing time: 125 Days and 16 Hours
Core Tip

Core Tip: Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus can affect the cardiovascular system leading to morbidity and mortality. This prospective study analysed the spectrum of cardiovascular involvement and aimed at determining the associations with clinical and laboratory parameters. Of the 211 patients with cardiac involvement, shock was the predominant finding followed by pericardial effusion, left ventricular (LV) dysfunction, mitral regurgitation and coronary aneurysm. LV function normalized in majority of children within two weeks. Most of the coronary abnormalities normalized within 6 months. None of the laboratory parameter was predictive of cardiac involvement.