Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Mar 9, 2024; 13(1): 87866
Published online Mar 9, 2024. doi: 10.5409/wjcp.v13.i1.87866
Childhood asthma biomarkers including zinc: An exploratory cross-sectional study
Hoda Atef Abdelsattar Ibrahim, Mona Mohsen, Boles Salep Aziz Hanna, Dina Mahmoud, Khaled Mohamed Abdelhamid El-Khashab
Hoda Atef Abdelsattar Ibrahim, Pediatric Clinical Nutrition Unit, Faculty of Medicine, Cairo University, Cairo 12613, Egypt
Hoda Atef Abdelsattar Ibrahim, Mona Mohsen, Boles Salep Aziz Hanna, Khaled Mohamed Abdelhamid El-Khashab, Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 12613, Egypt
Dina Mahmoud, Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo 12613, Egypt
Author contributions: All the authors have read and approved the final manuscript. Conceptualization, material preparation, manuscript drafting/writing, editing, data interpretation and project methodology were performed by Atef Abdelsattar Ibrahim H; Resources were developed by Mohsen M, Salep Aziz Hanna B and Mahmoud D; The arrangement of diagnostic investigations and project administration were performed by Atef Abdelsattar Ibrahim H, Salep Aziz Hanna B and Mahmoud D; Supervision was performed by Atef Abdelsattar Ibrahim H, Mohsen M, Mahmoud D and Mohamed Abdelhamid El-Khashab K; Formal analysis was performed by Atef Abdelsattar Ibrahim H.
Institutional review board statement: The study was approved by the Research Ethics Committee of the Faculty of Medicine, Cairo University, No. MS-587-2021.
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: The dataset of this study is available from the corresponding author upon reasonable request.
STROBE statement: The authors have read the STROBE statement, and the manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hoda Atef Abdelsattar Ibrahim, MD, Lecturer, Department of Pediatrics, Cairo University, No. 1 Gamaa Street, Giza, Cairo 12613, Egypt. hodaibrahim424@gmail.com
Received: August 30, 2023
Peer-review started: August 30, 2023
First decision: November 1, 2023
Revised: November 11, 2023
Accepted: November 29, 2023
Article in press: November 29, 2023
Published online: March 9, 2024
Processing time: 189 Days and 10 Hours
Core Tip

Core Tip: Serum zinc levels were higher in asthmatic children than in nonasthmatic children. However, the difference was not significant. Serum ferritin levels were significantly higher in asthmatic children, which may be due to its immunosuppressive properties. Serum ferritin should not be considered in the diagnosis of iron deficiency anemia in asthmatic children. Serum immunoglobulin E should not be applied to diagnose the severity of childhood asthma. Further studies that track biomarkers such as ferritin during asthma progression are needed.