©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Jun 9, 2023; 12(3): 68-76
Published online Jun 9, 2023. doi: 10.5409/wjcp.v12.i3.68
Published online Jun 9, 2023. doi: 10.5409/wjcp.v12.i3.68
Hirschsprung's disease associated enterocolitis: A comprehensive review
Eric M Gershon, Leonel Rodriguez, Ricardo A Arbizu, Section of Pediatric Gastroenterology, Yale University School of Medicine, New Haven, CT 06520, United States
Author contributions: Gerson EM, Rodriguez L and Arbizu RA contributed equally with initial manuscript draft and final approval; Arbizu RA performed concept design, revisions, and final approval.
Conflict-of-interest statement: The authors have nothing to disclose and have no potential conflict of interest.
Corresponding author: Ricardo A Arbizu, MD, MS, Assistant Professor, Section of Pediatric Gastroenterology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, United States. ricardo.arbizu@yale.edu
Received: December 29, 2022
Peer-review started: December 29, 2022
First decision: January 31, 2023
Revised: February 9, 2023
Accepted: March 21, 2023
Article in press: March 21, 2023
Published online: June 9, 2023
Processing time: 161 Days and 7.1 Hours
Peer-review started: December 29, 2022
First decision: January 31, 2023
Revised: February 9, 2023
Accepted: March 21, 2023
Article in press: March 21, 2023
Published online: June 9, 2023
Processing time: 161 Days and 7.1 Hours
Core Tip
Core Tip: Hirschsprung’s disease associated enterocolitis (HAEC) is an inflammatory complication of Hirschsprung’s disease (HSCR) with variable degrees of severity. It is important for pediatric providers to be aware of the signs and symptoms of HAEC as it can affect patients before or after corrective surgery. The pathogenesis of HAEC is multifactorial and previous and ongoing studies continue to improve our knowledge of this potentially fatal complication of HSCR and will ultimately allow clinicians to provide personalized care for these patients. In the meantime, current preventive measures and treatment guidelines have helped decrease the morbidity and mortality associated with HAEC.