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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Nov 9, 2022; 11(6): 455-462
Published online Nov 9, 2022. doi: 10.5409/wjcp.v11.i6.455
Published online Nov 9, 2022. doi: 10.5409/wjcp.v11.i6.455
Tangled relationship between insulin resistance and microalbuminuria in children with obesity
Alberto Maria Colasante, Mario Bartiromo, Michele Nardolillo, Stefano Guarino, Pierluigi Marzuillo, Giuseppe Salvatore R C Mangoni di S Stefano, Emanuele Miraglia del Giudice, Anna Di Sessa, Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80138, Italy
Author contributions: Colasante AM and Di Sessa A wrote the manuscript; Miraglia del Giudice E, Di Sessa A and Marzuillo P conceived the manuscript; Miraglia del Giudice E, Di Sessa A, and Marzuillo P supervised the manuscript drafting; Nardolillo M, Bartiromo M, Guarino S and Mangoni di S Stefano GSRC reviewed the literature data; Colasante AM and Nardolillo M prepared the table and the figure; each author contributed important intellectual content during manuscript drafting or revision.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Anna Di Sessa, MD, PhD, Research Fellow, Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Via De Crecchio, Naples 80138, Italy. anna.disessa@libero.it
Received: July 31, 2022
Peer-review started: July 31, 2022
First decision: September 5, 2022
Revised: September 19, 2022
Accepted: October 27, 2022
Article in press: October 27, 2022
Published online: November 9, 2022
Processing time: 99 Days and 6.6 Hours
Peer-review started: July 31, 2022
First decision: September 5, 2022
Revised: September 19, 2022
Accepted: October 27, 2022
Article in press: October 27, 2022
Published online: November 9, 2022
Processing time: 99 Days and 6.6 Hours
Core Tip
Core Tip: In addition to the well-known cardiometabolic consequences of obesity (including fatty liver, type 2 diabetes, metabolic syndrome, and cardiovascular disease), early kidney damage has been also demonstrated in children with obesity. As a consequence of the dysmetabolism, the occurrence of microalbuminuria as an early marker of kidney dysfunction has been widely described in these subjects and closely linked to insulin resistance. Given the lack of extensive pediatric data and the prognostic implications of this intriguing association, a better knowledge in this field is needed to counteract the intrinsic increased cardiometabolic risk of children with obesity.