Yellanthoor RB, Rajamanickam D. Correlation of cardiac troponin T levels with inotrope requirement, hypoxic-ischemic encephalopathy, and survival in asphyxiated neonates. World J Clin Pediatr 2022; 11(1): 85-92 [PMID: 35096549 DOI: 10.5409/wjcp.v11.i1.85]
Corresponding Author of This Article
Ramesh Bhat Yellanthoor, MBBS, MD, Doctor, Professor, Head of Unit 1, Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education (MAHE) University, Udupi District, Manipal 576104, Karnataka, India. docrameshbhat@yahoo.co.in
Research Domain of This Article
Pediatrics
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Pediatr. Jan 9, 2022; 11(1): 85-92 Published online Jan 9, 2022. doi: 10.5409/wjcp.v11.i1.85
Correlation of cardiac troponin T levels with inotrope requirement, hypoxic-ischemic encephalopathy, and survival in asphyxiated neonates
Ramesh Bhat Yellanthoor, Dineshkumar Rajamanickam
Ramesh Bhat Yellanthoor, Head of Unit 1, Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education (MAHE) University, Manipal 576104, Karnataka, India
Dineshkumar Rajamanickam, Department of Paediatrics, Kasturba Medical College, Manipal Academy of Higher Education (MAHE) University, Manipal 576104, Karnataka, India
Author contributions: Yellanthoor RB and Rajamanickam D conceptualized the study, analyzed and interpreted the data; Rajamanickam D collected the data; Yellanthoor RB wrote the manuscript and critically revised it; both Yellanthoor RB and Rajamanickam D approved the final manuscript.
Institutional review board statement: Ethical approval was obtained from the Institutional Ethical Committee.
Conflict-of-interest statement: Authors declare that there is no conflict of interest.
Data sharing statement: Authors agree to share the data at the reasonable request.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—a checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ramesh Bhat Yellanthoor, MBBS, MD, Doctor, Professor, Head of Unit 1, Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education (MAHE) University, Udupi District, Manipal 576104, Karnataka, India. docrameshbhat@yahoo.co.in
Received: January 9, 2021 Peer-review started: January 9, 2021 First decision: May 6, 2021 Revised: June 20, 2021 Accepted: December 7, 2021 Article in press: December 7, 2021 Published online: January 9, 2022 Processing time: 362 Days and 16.3 Hours
ARTICLE HIGHLIGHTS
Research background
The myocardial ischemic injury in asphyxiated neonates complicates management and may lead to higher mortality. Cardiac troponin T (cTnT) levels are expected to rise early in myocardial ischemia and remain high for about two weeks.
Research motivation
cTnT levels are better markers than Serum creatinine kinase muscle-brain isoenzyme levels and could be predictive of mortality.
Research objectives
The present study determined cTnT levels in asphyxiated neonates and found out its relationship with echocardiography findings, inotrope requirement, hypoxic-ischemic encephalopathy (HIE) stages, and mortality.
Research methods
cTnT levels are estimated in all asphyxiated neonates along with echocardiography evaluation.
Research results
Among asphyxiated neonates, cTnT levels were elevated in 71.9%. Further, the cTnT levels correlated with increasing grades of ischemic changes in echocardiography. Elevated cTnT levels in 58% of neonates with normal echocardiography findings suggested its role as a biomarker. cTnT levels in neonates with HIE stage III were significantly higher than those with HIE stage I and II. cTnT levels were higher in non-survivors than survivors.
Research conclusions
cTnT could be a potential and clinically useful biomarker for asphyxia related myocardial injury in neonates.
Research perspectives
Further studies to determine the exact cut of levels of cTnT predicting mortality are needed.
