Krishnan S, Anderson MP, Fields DA, Misra M. Abdominal obesity adversely affects bone mass in children. World J Clin Pediatr 2018; 7(1): 43-48 [PMID: 29456931 DOI: 10.5409/wjcp.v7.i1.43]
Corresponding Author of This Article
Sowmya Krishnan, MD, Associate Professor, Department of Pediatrics, University of Oklahoma Health Sciences Center, Harold Hamm Diabetes Center, 1200, N Children’s Avenue, Suite 4500, Oklahoma City, OK 73104, United States. sowmya-krishnan@ouhsc.edu
Research Domain of This Article
Pediatrics
Article-Type of This Article
Case Control Study
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Krishnan S, Anderson MP, Fields DA, Misra M. Abdominal obesity adversely affects bone mass in children. World J Clin Pediatr 2018; 7(1): 43-48 [PMID: 29456931 DOI: 10.5409/wjcp.v7.i1.43]
World J Clin Pediatr. Feb 8, 2018; 7(1): 43-48 Published online Feb 8, 2018. doi: 10.5409/wjcp.v7.i1.43
Abdominal obesity adversely affects bone mass in children
Madhusmita Misra, David A Fields, Michael P Anderson, Sowmya Krishnan
Sowmya Krishnan, David A Fields, Department of Pediatrics, University of Oklahoma Health Sciences Center, Harold Hamm Diabetes Center, Oklahoma City, OK 73104, United States
Michael P Anderson, College of Public Health, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, United States
Madhusmita Misra, Massachusetts General Hospital for Children and Harvard Medical School, Boston, MA 02114, United States
Author contributions: Krishnan S collected data; Anderson MP helped in statistical analysis; Fields DA and Misra M helped in writing the paper.
Supported by Novo-Nordisk, No. C7042301.
Institutional review board statement: The study has been approved by the University of Oklahoma Health sciences Center Institutional review board research ethics committee and has been performed in accordance with the ethical standards as laid down in the 1964 declaration of Helsinki and its later amendments.
Informed consent statement: All study participants or their legal guardians provided informed consent prior to enrollment in the study.
Conflict-of-interest statement: David A Fields has received grant funding from Nestle and Mead Johnson.
Data sharing statement: Consent was not obtained from participants for sharing data but presented data is anonymized and risk of identification is low.
Correspondence to: Sowmya Krishnan, MD, Associate Professor, Department of Pediatrics, University of Oklahoma Health Sciences Center, Harold Hamm Diabetes Center, 1200, N Children’s Avenue, Suite 4500, Oklahoma City, OK 73104, United States. sowmya-krishnan@ouhsc.edu
Received: August 25, 2017 Peer-review started: September 17, 2017 First decision: October 23, 2017 Revised: November 8, 2017 Accepted: November 27, 2017 Article in press: November 27, 2017 Published online: February 8, 2018 Processing time: 143 Days and 14.1 Hours
Abstract
AIM
To determine the effect of childhood obesity and insulin resistance on bone health.
METHODS
We conducted a cross sectional study in pubertal adolescents and young adults 13-20 years old who were either overweight/obese or normal weight. Participants were Tanner 3 or above for pubertal stage, and had fasting blood work done to measure glucose, insulin, C-reactive protein and lipid levels. Homeostatic model of insulin resistance (HOMA-IR) was calculated using the formula (Fasting Blood Glucose *Insulin/405). Body composition and bone mineral density were measured using dual energy X-ray absorptiometry (DXA; Hologic QDR 4500, Waltham, MA, United Kingdom).
RESULTS
Percent trunk fat was associated inversely with whole body bone mineral content (BMC), whereas HOMA-IR was associated positively with whole body BMC.
CONCLUSION
Our results suggest that abdominal adiposity may have an adverse effect on whole body bone parameters and that this effect is not mediated by insulin resistance.
Core tip: Abdominal adiposity has an adverse impact on whole body bone mineral content in adolescents. This effect does not seem to be mediated by the increased insulin resistance associated with increased abdominal adiposity. Attention to body composition rather than just body weight is needed to counsel adolescents regarding optimal bone health.
