Mechanical circulatory support in lung transplantation: Cardiopulmonary bypass, extracorporeal life support, and ex-vivo lung perfusion

doi:10.5320/wjr.v5.i2.78

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Jul 28, 2015 (publication date) through Nov 2, 2025

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World Journal of Respirology

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Respirol. Jul 28, 2015; 5(2): 78-92
Published online Jul 28, 2015. doi: 10.5320/wjr.v5.i2.78

Table 1 Comparison of mechanical circulatory support modalities

	Open/closed	Pump	Cannulation	Indications	Phase of transplant
CPB	Open	Yes (Centrifugal or Roller)	Central (intrathoracic)	Hemodynamic instability	Intraoperative
				Pulmonary hypertension
				Right ventricular failure
				En bloc double-LTx
ECLS/iLA	Closed	No (Pump may be added)	Usually peripheral (also PA-LA)	Refractory:	Bridge to Tx (Awake)
ECLS/iLA	Closed	No (Pump may be added)	Usually peripheral (also PA-LA)	Hypercarbia (PCO2 > 80 mmHg)	Bridge to Tx (Awake)
VV-ECMO	Closed	Yes (Centrifugal or Roller)	Peripheral (BCDLC)	Refractory:	Bridge to Tx (Awake)
				Hypoxia (PaO2:FiO2 < 80 mmHg)	Graft Salvage
				Hypercarbia PCO2 > 80 mmHg
VA-ECMO	Closed	Yes (Centrifugal or Roller)	Peripheral (sometimes Central)	Hemodynamic instability	Bridge to Tx
				Pulmonary hypertension	Intraoperative
				Right heart failure	Graft Salvage

CPB: Cardiopulmonary bypass; ECLS: Extracorporeal lung support; iLA: Interventional lung assist; VV: Venovenous; VA: Venoarterial; ECMO: Extracorporeal membrane oxygenation; PA-LA: Pulmonary artery-left atrium; BCDLC: Bi-caval dual lumen cannula.

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Citation: Bennett SC, Beal EW, Dumond CA, Preston T, Ralston J, Pope-Harman A, Black S, Hayes Jr D, Whitson BA. Mechanical circulatory support in lung transplantation: Cardiopulmonary bypass, extracorporeal life support, and ex-vivo lung perfusion. World J Respirol 2015; 5(2): 78-92
URL: https://www.wjgnet.com/2218-6255/full/v5/i2/78.htm
DOI: https://dx.doi.org/10.5320/wjr.v5.i2.78