©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Respirol. Jul 28, 2015; 5(2): 126-134
Published online Jul 28, 2015. doi: 10.5320/wjr.v5.i2.126
Published online Jul 28, 2015. doi: 10.5320/wjr.v5.i2.126
Caveolae, caveolin-1 and cavin-1: Emerging roles in pulmonary hypertension
Sukrutha Chettimada, Jincheng Yang, Hyung-geun Moon, Yang Jin, Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, United States
Author contributions: All the authors equally contributed to this work.
Conflict-of-interest statement: All the authors have no conflict of interests.
Correspondence to: Yang Jin, MD, PhD, Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, United States. yjin@rics.bwh.harvard.edu
Telephone: +1-617-7324334 Fax: +1-617-7325500
Received: August 8, 2014
Peer-review started: August 8, 2014
First decision: December 26, 2014
Revised: February 25, 2015
Accepted: June 15, 2015
Article in press: June 16, 2015
Published online: July 28, 2015
Processing time: 361 Days and 7.5 Hours
Peer-review started: August 8, 2014
First decision: December 26, 2014
Revised: February 25, 2015
Accepted: June 15, 2015
Article in press: June 16, 2015
Published online: July 28, 2015
Processing time: 361 Days and 7.5 Hours
Core Tip
Core tip: Pulmonary hypertension is a disease condition that is associated with a wide range of underlying medical conditions and environmental exposures. Currently, the exact molecular mechanisms underlying the pathogenesis of pulmonary hypertension remain unclear. This review is to outline and discuss the current understandings on the novel roles of a group of cell surface proteins, cav-1, -2 and cavin-1, on the development of pulmonary hypertension and vascular remodeling.