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For: Shimura R, Tatsumi K, Nakamura A, Kasahara Y, Tanabe N, Takiguchi Y, Kuriyama T. Fat accumulation, leptin, and hypercapnia in obstructive sleep apnea-hypopnea syndrome. Chest 2005;127:543-9. [PMID: 15705994 DOI: 10.1378/chest.127.2.543] [Citation(s) in RCA: 81] [Impact Index Per Article: 4.1] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/10/2023] Open

For:	Shimura R, Tatsumi K, Nakamura A, Kasahara Y, Tanabe N, Takiguchi Y, Kuriyama T. Fat accumulation, leptin, and hypercapnia in obstructive sleep apnea-hypopnea syndrome. Chest 2005;127:543-9. [PMID: 15705994 DOI: 10.1378/chest.127.2.543] [Citation(s) in RCA: 81] [Impact Index Per Article: 4.1] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/10/2023] Open

Number

Cited by Other Article(s)

Tharumakunarajah R, Lee A, Hawcutt DB, Harman NL, Sinha IP. The Impact of Malnutrition on the Developing Lung and Long-Term Lung Health: A Narrative Review of Global Literature. Pulm Ther 2024;10:155-170. [PMID: 38758409 PMCID: PMC11282003 DOI: 10.1007/s41030-024-00257-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/04/2024] [Accepted: 04/12/2024] [Indexed: 05/18/2024] Open

Chang JL, Goldberg AN, Alt JA, Alzoubaidi M, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera JE, Bartley BL, Billings ME, Boon MS, Bosschieter P, Braverman I, Brodie K, Cabrera-Muffly C, Caesar R, Cahali MB, Cai Y, Cao M, Capasso R, Caples SM, Chahine LM, Chang CP, Chang KW, Chaudhary N, Cheong CSJ, Chowdhuri S, Cistulli PA, Claman D, Collen J, Coughlin KC, Creamer J, Davis EM, Dupuy-McCauley KL, Durr ML, Dutt M, Ali ME, Elkassabany NM, Epstein LJ, Fiala JA, Freedman N, Gill K, Boyd Gillespie M, Golisch L, Gooneratne N, Gottlieb DJ, Green KK, Gulati A, Gurubhagavatula I, Hayward N, Hoff PT, Hoffmann OM, Holfinger SJ, Hsia J, Huntley C, Huoh KC, Huyett P, Inala S, Ishman SL, Jella TK, Jobanputra AM, Johnson AP, Junna MR, Kado JT, Kaffenberger TM, Kapur VK, Kezirian EJ, Khan M, Kirsch DB, Kominsky A, Kryger M, Krystal AD, Kushida CA, Kuzniar TJ, Lam DJ, Lettieri CJ, Lim DC, Lin HC, Liu SY, MacKay SG, Magalang UJ, Malhotra A, Mansukhani MP, Maurer JT, May AM, Mitchell RB, Mokhlesi B, Mullins AE, Nada EM, Naik S, Nokes B, Olson MD, Pack AI, Pang EB, Pang KP, Patil SP, Van de Perck E, Piccirillo JF, Pien GW, et alChang JL, Goldberg AN, Alt JA, Alzoubaidi M, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera JE, Bartley BL, Billings ME, Boon MS, Bosschieter P, Braverman I, Brodie K, Cabrera-Muffly C, Caesar R, Cahali MB, Cai Y, Cao M, Capasso R, Caples SM, Chahine LM, Chang CP, Chang KW, Chaudhary N, Cheong CSJ, Chowdhuri S, Cistulli PA, Claman D, Collen J, Coughlin KC, Creamer J, Davis EM, Dupuy-McCauley KL, Durr ML, Dutt M, Ali ME, Elkassabany NM, Epstein LJ, Fiala JA, Freedman N, Gill K, Boyd Gillespie M, Golisch L, Gooneratne N, Gottlieb DJ, Green KK, Gulati A, Gurubhagavatula I, Hayward N, Hoff PT, Hoffmann OM, Holfinger SJ, Hsia J, Huntley C, Huoh KC, Huyett P, Inala S, Ishman SL, Jella TK, Jobanputra AM, Johnson AP, Junna MR, Kado JT, Kaffenberger TM, Kapur VK, Kezirian EJ, Khan M, Kirsch DB, Kominsky A, Kryger M, Krystal AD, Kushida CA, Kuzniar TJ, Lam DJ, Lettieri CJ, Lim DC, Lin HC, Liu SY, MacKay SG, Magalang UJ, Malhotra A, Mansukhani MP, Maurer JT, May AM, Mitchell RB, Mokhlesi B, Mullins AE, Nada EM, Naik S, Nokes B, Olson MD, Pack AI, Pang EB, Pang KP, Patil SP, Van de Perck E, Piccirillo JF, Pien GW, Piper AJ, Plawecki A, Quigg M, Ravesloot MJ, Redline S, Rotenberg BW, Ryden A, Sarmiento KF, Sbeih F, Schell AE, Schmickl CN, Schotland HM, Schwab RJ, Seo J, Shah N, Shelgikar AV, Shochat I, Soose RJ, Steele TO, Stephens E, Stepnowsky C, Strohl KP, Sutherland K, Suurna MV, Thaler E, Thapa S, Vanderveken OM, de Vries N, Weaver EM, Weir ID, Wolfe LF, Tucker Woodson B, Won CH, Xu J, Yalamanchi P, Yaremchuk K, Yeghiazarians Y, Yu JL, Zeidler M, Rosen IM. International Consensus Statement on Obstructive Sleep Apnea. Int Forum Allergy Rhinol 2023;13:1061-1482. [PMID: 36068685 PMCID: PMC10359192 DOI: 10.1002/alr.23079] [Show More Authors] [Citation(s) in RCA: 126] [Impact Index Per Article: 63.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/12/2022] [Revised: 08/12/2022] [Accepted: 08/18/2022] [Indexed: 11/08/2022]

Affiliation(s)

Jolie L. Chang University of California, San Francisco, California, USA
Andrew N. Goldberg University of California, San Francisco, California, USA
Jeremiah A. Alt University of Utah, Salt Lake City, Utah, USA
Mohammed Alzoubaidi Northwestern University, Chicago, Illinois, USA
Liza Ashbrook University of California, San Francisco, California, USA
Dennis Auckley Case Western Reserve University, Cleveland, Ohio, USA
Indu Ayappa Icahn School of Medicine at Mount Sinai, New York, New York, USA
Hira Bakhtiar Norwalk Hospital, Norwalk, Connecticut, USA
José E. Barrera Uniformed Services University, Washington D.C., USA
Bethany L. Bartley Harvard Medical School, Boston, Massachusetts, USA
Martha E. Billings University of Washington, Seattle, Washington, USA
Maurits S. Boon Sidney Kimmel Medical Center at Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Pien Bosschieter Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands
Itzhak Braverman Hillel Yaffe Medical Center, Hadera Technion, Faculty of Medicine, Hadera, Israel
Kara Brodie University of California, San Francisco, California, USA
Cristina Cabrera-Muffly University of Colorado School of Medicine, Aurora, Colorado, USA
Ray Caesar Stone Oak Orthodontics, San Antonio, Texas, USA
Michel B. Cahali University of Sao Paulo, São Paulo, Brazil
Yi Cai University of California, San Francisco, California, USA
Michelle Cao Stanford University, Palo Alto, California, USA
Robson Capasso Stanford University, Palo Alto, California, USA
Sean M. Caples Mayo Clinic, Rochester, Minnesota, USA
Lana M. Chahine University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Corissa P. Chang University of Pennsylvania, Philadelphia, Pennsylvania, USA
Katherine W. Chang Washington University, St. Louis, Missouri, USA
Nilika Chaudhary Brigham and Women’s Hospital, Boston, MA, USA
Crystal S. J. Cheong National University Hospital, Singapore
Susmita Chowdhuri Wayne State University and John D. Dingell VA Medical Center, Detroit, Michigan, USA
Peter A. Cistulli Faculty of Medicine and Health, University of Sydney, Sydney, Australia
David Claman University of California, San Francisco, California, USA
Jacob Collen Uniformed Services University, Bethesda, Maryland, USA
Kevin C. Coughlin University of Tennessee, Memphis, Tennessee, USA
Jennifer Creamer Uniformed Services University, Bethesda, Maryland, USA
Eric M. Davis University of Virginia, Charlottesville, Virginia, USA
Kara L. Dupuy-McCauley Mayo Clinic, Rochester, Minnesota, USA
Megan L. Durr Kaiser Permanente, Oakland, California, USA
Mohan Dutt University of Michigan, Ann Arbor, Michigan, USA
Mazen El Ali University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Nabil M. Elkassabany University of Virginia, Charlottesville, Virginia, USA
Lawrence J. Epstein Harvard Medical School, Boston, Massachusetts, USA
Justin A. Fiala Northwestern University, Chicago, Illinois, USA
Neil Freedman University of Chicago, Chicago, Illinois, USA
Kirat Gill Stanford University, Palo Alto, California, USA
M. Boyd Gillespie University of Tennessee, Memphis, Tennessee, USA
Lea Golisch University Hospital Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
Nalaka Gooneratne University of Pennsylvania, Philadelphia, Pennsylvania, USA
Daniel J. Gottlieb Harvard Medical School, Boston, Massachusetts, USA
Katherine K. Green University of Colorado, Aurora, Colorado, USA
Arushi Gulati University of California, San Francisco, California, USA
Indira Gurubhagavatula University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nathan Hayward Monash Health, Victoria, Australia
Paul T. Hoff University of Michigan, Ann Arbor, Michigan, USA
Oliver M.G. Hoffmann University Hospital Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
Steven J. Holfinger Ohio State University, Columbus, Ohio, USA
Jennifer Hsia University of Minnesota, Minneapolis, Minnesota, USA
Colin Huntley Sidney Kimmel Medical Center at Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Kevin C. Huoh University of California, Irvine, California, USA
Phillip Huyett Harvard Medical School, Boston, Massachusetts, USA
Sanjana Inala Icahn School of Medicine at Mount Sinai, New York, New York, USA
Stacey L. Ishman University of Cincinnati, Cincinnati, Ohio, USA
Tarun K. Jella Case Western Reserve University, Cleveland, Ohio, USA
Aesha M. Jobanputra Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Andrew P. Johnson University of Colorado School of Medicine, Aurora, Colorado, USA
Mithri R. Junna Mayo Clinic, Rochester, Minnesota, USA
Jenna T. Kado University of Toledo, Toledo, Ohio, USA
Thomas M. Kaffenberger University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Vishesh K. Kapur University of Washington, Seattle, Washington, USA
Eric J. Kezirian University of Southern California, Los Angeles, California, USA
Meena Khan Ohio State University, Columbus, Ohio, USA
Douglas B. Kirsch University of North Carolina School of Medicine, Charlotte
Alan Kominsky Cleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA
Meir Kryger Yale School of Medicine, New Haven, Connecticut, USA
Andrew D. Krystal University of California, San Francisco, California, USA
Clete A. Kushida Stanford University, Palo Alto, California, USA
Thomas J. Kuzniar University of Chicago, Chicago, Illinois, USA
Derek J. Lam Oregon Health and Science University, Portland, Oregon, USA
Christopher J. Lettieri Uniformed Services University, Bethesda, Maryland, USA
Diane C. Lim University of Miami, Miami, Florida, USA
Hsin-Ching Lin Chang Gung University, Kaohsiung, Taiwan
Stanley Y.C. Liu Stanford University, Palo Alto, California, USA
Stuart G. MacKay University of Wollongong, Wollongong, Australia
Ulysses J. Magalang Ohio State University, Columbus, Ohio, USA
Atul Malhotra University of California, San Diego, California, USA
Meghna P. Mansukhani Mayo Clinic, Rochester, Minnesota, USA
Joachim T. Maurer University Hospital Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
Anna M. May Case Western Reserve University, Cleveland, Ohio, USA
Ron B. Mitchell University of Texas, Southwestern and Children’s Medical Center Dallas, Texas, USA
Babak Mokhlesi Rush University Medical Center, Chicago, IL, USA
Anna E. Mullins University of Chicago, Chicago, Illinois, USA
Eman M. Nada Stony Brook University, New York, New York, USA
Sreelatha Naik Geisinger Health System, Danville, California, USA
Brandon Nokes University of California, San Diego, California, USA
Michael D. Olson Mayo Clinic, Rochester, Minnesota, USA
Allan I. Pack University of Pennsylvania, Philadelphia, Pennsylvania, USA
Edward B. Pang University of Glasgow, Glasgow, UK
Kenny P. Pang Paragon Medical Centre, Singapore
Susheel P. Patil Case Western Reserve University, Cleveland, Ohio, USA
Eli Van de Perck University of Antwerp, Belgium
Jay F. Piccirillo Washington University, St. Louis, Missouri, USA
Grace W. Pien Johns Hopkins University, Baltimore, Maryland, USA
Amanda J. Piper University of Sydney, Sydney, Australia
Andrea Plawecki Henry Ford Health, Detroit, Michigan, USA
Mark Quigg University of Virginia, Charlottesville, Virginia, USA
Madeline J.L. Ravesloot OLVG, Amsterdam, The Netherlands
Susan Redline Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Brian W. Rotenberg Western University, Ontario, Canada
Armand Ryden Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
Kathleen F. Sarmiento University of California, San Francisco, California, USA
Firas Sbeih Cleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA
Amy E. Schell University of Colorado, Aurora, Colorado, USA
Christopher N. Schmickl University of California, San Diego, California, USA
Helena M. Schotland Icahn School of Medicine at Mount Sinai, New York, New York, USA
Richard J. Schwab University of Pennsylvania, Philadelphia, Pennsylvania, USA
Jiyeon Seo University of California, Los Angeles, California, USA
Neomi Shah Icahn School of Medicine at Mount Sinai, New York, New York, USA
Anita Valanju Shelgikar University of Michigan, Ann Arbor, Michigan, USA
Isaac Shochat Hillel Yaffe Medical Center, Hadera, Israel
Ryan J. Soose University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Toby O. Steele University of California, Davis, California, USA
Erika Stephens University of California, San Francisco, California, USA
Carl Stepnowsky University of California, San Diego, California, USA
Kingman P. Strohl Case Western Reserve University, Cleveland, Ohio, USA
Kate Sutherland University of Sydney, Sydney, Australia
Maria V. Suurna Weill Cornell Medicine, New York, New York, USA
Erica Thaler University of Pennsylvania, Philadelphia, Pennsylvania, USA
Sritika Thapa Yale School of Medicine, New Haven, Connecticut, USA
Olivier M. Vanderveken University of Antwerp, Belgium
Nico de Vries Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands
Edward M. Weaver University of Washington, Seattle, Washington, USA
Ian D. Weir Yale School of Medicine, New Haven, Connecticut, USA
Lisa F. Wolfe Northwestern University, Chicago, Illinois, USA
B. Tucker Woodson Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Christine H.J. Won Yale School of Medicine, New Haven, Connecticut, USA
Josie Xu University of Toronto, Ontario, Canada
Pratyusha Yalamanchi University of Michigan, Ann Arbor, Michigan, USA
Kathleen Yaremchuk Henry Ford Health, Detroit, Michigan, USA
Yerem Yeghiazarians University of California, San Francisco, California, USA
Jason L. Yu Emory University, Georgia, USA
Michelle Zeidler University of California, Los Angeles, California, USA
Ilene M. Rosen University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Moreno-Fernandez J, Ochoa J, Ojeda ML, Nogales F, Carreras O, Díaz-Castro J. Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review. J Physiol Biochem 2022;78:581-591. [PMID: 35316507 PMCID: PMC8938224 DOI: 10.1007/s13105-022-00887-4] [Citation(s) in RCA: 15] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/27/2021] [Accepted: 03/03/2022] [Indexed: 02/06/2023]

Huang YC, Huang SH, Chung RJ, Wang BL, Chung CH, Chien WC, Sun CA, Yu PC, Lu CH. Obese Patients Experience More Severe CSA than Non-Obese Patients. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022;19:ijerph19031289. [PMID: 35162313 PMCID: PMC8835470 DOI: 10.3390/ijerph19031289] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 12/22/2021] [Revised: 01/17/2022] [Accepted: 01/18/2022] [Indexed: 12/04/2022]

Affiliation(s)

Yao-Ching Huang Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan; (Y.-C.H.); (S.-H.H.); (R.-J.C.) Department of Medical Research, Tri-Service General Hospital, Taipei 11490, Taiwan;
Shi-Hao Huang Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan; (Y.-C.H.); (S.-H.H.); (R.-J.C.)
Ren-Jei Chung Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan; (Y.-C.H.); (S.-H.H.); (R.-J.C.)
Bing-Long Wang School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan;
Chi-Hsiang Chung Department of Medical Research, Tri-Service General Hospital, Taipei 11490, Taiwan; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan Taiwanese Injury Prevention and Safety Promotion Association (TIPSPA), Taipei 11490, Taiwan
Wu-Chien Chien Department of Medical Research, Tri-Service General Hospital, Taipei 11490, Taiwan; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan Taiwanese Injury Prevention and Safety Promotion Association (TIPSPA), Taipei 11490, Taiwan Correspondence: (W.-C.C.); (C.-H.L.)
Chien-An Sun Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City 242062, Taiwan; Big Data Center, College of Medicine, Fu-Jen Catholic University, New Taipei City 242062, Taiwan
Pi-Ching Yu Graduate Institute of Medicine, National Defense Medical Center, Taipei 11490, Taiwan; Cardiovascular Intersive Care Unit, Department of Critical Care Medicine, Far-Eastern Memorial Hospital, New Taipei City 10602, Taiwan
Chieh-Hua Lu Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei 11490, Taiwan Correspondence: (W.-C.C.); (C.-H.L.)

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Herkenrath SD, Treml M, Hagmeyer L, Matthes S, Randerath WJ. Severity stages of obesity-related breathing disorders - a cross-sectional cohort study. Sleep Med 2022;90:9-16. [PMID: 35051737 DOI: 10.1016/j.sleep.2021.12.015] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/29/2021] [Revised: 12/22/2021] [Accepted: 12/27/2021] [Indexed: 11/16/2022]

Kaw R, Wong J, Mokhlesi B. Obesity and Obesity Hypoventilation, Sleep Hypoventilation, and Postoperative Respiratory Failure. Anesth Analg 2021;132:1265-1273. [PMID: 33857968 DOI: 10.1213/ane.0000000000005352] [Citation(s) in RCA: 20] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/05/2022]

Obesity Hypoventilation: Traditional Versus Nontraditional Populations. Sleep Med Clin 2020;15:449-459. [PMID: 33131656 DOI: 10.1016/j.jsmc.2020.08.001] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/21/2022]

Keskin N, Keskin S. Association between adenotonsillar hypertrophy and leptin, ghrelin and IGF-1 levels in children. Auris Nasus Larynx 2020;48:248-254. [PMID: 32826092 DOI: 10.1016/j.anl.2020.08.002] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/20/2020] [Revised: 07/11/2020] [Accepted: 08/03/2020] [Indexed: 10/23/2022]

Abstract

OBJECTIVE

Developmental and growth retardation is a condition that is often encountered among children with adenotonsillar hypertrophy (ATH). Leptin, ghrelin and IGF-1 are important factors in growth and development for children. The aim of the study was to investigate serum leptin, ghrelin and IGF-1 levels in children with ATH compare with healthy controls.

MATERIAL METHOD

82 children between ages 6-12 were included in this study, divided into two groups. The first group being the study-group consisted of 42 children with obstructive adenotonsillar hypertrophy and the second group being the control-group consisted of 40 healthy children. At 08:30 a.m., peripheral blood samples were extracted from children from both groups to examine the serum levels, and kept in -40 °C until the Elisa test.

RESULTS

Leptin serum level of the control-group was found to be statistically significantly higher than the serum leptin level of the ATH group (p = 0,049; p < 0.05). Body mass indexes of the children with ATH were found to be statistically significantly lower than the body mass index (BMI) of the control group (p = 0,001; p < 0.05). In contrast, there was no statistically significant difference between ghrelin and IGF-1 levels between the ATH and control group (p = 0.193, p > 0.05 and p = 0.478, p > 0.05, respectively).

CONCLUSION

Upper airway infections are common in children with ATH. Increased airway infections and obstructive enlarged adenotonsillar lymphoid tissue which are caused swallowing difficulties can lead to reduced oral intake and fat tissue. It has led us to think that, ghrelin levels may be increasing secondary to these problems in children with ATH. Furthermore, BMI and leptin would be lower in children with ATH, considering adipose tissue was lesser and leptin was being synthesized and oscillated out of the fat cells of the tissue in these children.

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Herkenrath S, Randerath W. Adipositasassoziierte Atmungsstörungen –„State of the Art“. SOMNOLOGIE 2020. [DOI: 10.1007/s11818-020-00258-5] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/21/2022]

Perioperative management of OSA in the obese patient population. Int Anesthesiol Clin 2020;58:47-52. [PMID: 32282579 DOI: 10.1097/aia.0000000000000282] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]

Kimura Y, Kasai T, Tomita Y, Kasagi S, Takaya H, Kato M, Kawana F, Narui K. Relationship between metabolic syndrome and hypercapnia among obese patients with sleep apnea. World J Respirol 2020;10:1-10. [DOI: 10.5320/wjr.v10.i1.1] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/23/2019] [Revised: 12/16/2019] [Accepted: 12/23/2019] [Indexed: 02/06/2023] Open

Herkenrath SD, Randerath WJ. Neues zur Pathophysiologie schlafbezogener Atmungsstörungen. SOMNOLOGIE 2019. [DOI: 10.1007/s11818-019-00220-0] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/31/2022]

Mashaqi S, Badr MS. The Impact of Obstructive Sleep Apnea and Positive Airway Pressure Therapy on Metabolic Peptides Regulating Appetite, Food Intake, Energy Homeostasis, and Systemic Inflammation: A Literature Review. J Clin Sleep Med 2019;15:1037-1050. [PMID: 31383242 DOI: 10.5664/jcsm.7890] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/17/2018] [Accepted: 04/04/2019] [Indexed: 12/13/2022]

Herkenrath SD, Randerath WJ. More than Heart Failure: Central Sleep Apnea and Sleep-Related Hypoventilation. Respiration 2019;98:95-110. [PMID: 31291632 DOI: 10.1159/000500728] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/09/2018] [Accepted: 05/02/2019] [Indexed: 12/29/2022] Open

Bingol Z, Karaayvaz EB, Telci A, Bilge AK, Okumus G, Kiyan E. Leptin and adiponectin levels in obstructive sleep apnea phenotypes. Biomark Med 2019;13:865-874. [PMID: 31210052 DOI: 10.2217/bmm-2018-0293] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/11/2022] Open

Sunwoo BY. Obesity Hypoventilation: Pathophysiology, Diagnosis, and Treatment. CURRENT PULMONOLOGY REPORTS 2019. [DOI: 10.1007/s13665-019-0223-x] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/30/2022]

Kaw RK. Spectrum of postoperative complications in pulmonary hypertension and obesity hypoventilation syndrome. Curr Opin Anaesthesiol 2018;30:140-145. [PMID: 27906717 DOI: 10.1097/aco.0000000000000420] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/25/2022]

Tzelepis GE. Chest Wall Diseases. Clin Chest Med 2018;39:281-296. [DOI: 10.1016/j.ccm.2018.01.002] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/28/2022]

Kaczyńska K, Zając D, Wojciechowski P, Kogut E, Szereda-Przestaszewska M. Neuropeptides and breathing in health and disease. Pulm Pharmacol Ther 2017;48:217-224. [PMID: 29223509 DOI: 10.1016/j.pupt.2017.12.001] [Citation(s) in RCA: 21] [Impact Index Per Article: 2.6] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/06/2017] [Revised: 11/20/2017] [Accepted: 12/05/2017] [Indexed: 12/18/2022]

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The Bariatric Airway. Int Anesthesiol Clin 2016;55:65-85. [PMID: 27941367 DOI: 10.1097/aia.0000000000000133] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/20/2022]

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Polotsky M, Elsayed-Ahmed AS, Pichard L, Harris CC, Smith PL, Schneider H, Kirkness JP, Polotsky V, Schwartz AR. Effects of leptin and obesity on the upper airway function. J Appl Physiol (1985) 2012;112:1637-43. [PMID: 22345430 DOI: 10.1152/japplphysiol.01222.2011] [Citation(s) in RCA: 62] [Impact Index Per Article: 4.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022] Open

Abstract

Obesity is associated with alterations in upper airway collapsibility during sleep. Obese, leptin-deficient mice demonstrate blunted ventilatory control, leading us to hypothesize that (1) obesity and leptin deficiency would predispose to worsening neuromechanical upper airway function and that (2) leptin replacement would acutely reverse neuromuscular defects in the absence of weight loss. In age-matched, anesthetized, spontaneously breathing C57BL/6J (BL6) and ob(-)/ob(-) mice, we characterized upper airway pressure-flow dynamics during ramp decreases in nasal pressure (P(N)) to determine the passive expiratory critical pressure (P(CRIT)) and active responses to reductions in P(N), including the percentage of ramps showing inspiratory flow limitation (IFL; frequency), the P(N) threshold at which IFL developed, maximum inspiratory airflow (Vi(max)), and genioglossus electromyographic (EMG(GG)) activity. Elevations in body weight were associated with progressive elevations in P(CRIT) (0.1 ± 0.02 cmH(2)O/g), independent of mouse strain. P(CRIT) was also elevated in ob(-)/ob(-) compared with BL6 mice (1.6 ± 0.1 cmH(2)O), independent of weight. Both obesity and leptin deficiency were associated with significantly higher IFL frequency and P(N) threshold and lower VI(max). Very obese ob(-)/ob(-) mice treated with leptin compared with nontreated mice showed a decrease in IFL frequency (from 63.5 ± 2.9 to 30.0 ± 8.6%) and P(N) threshold (from -0.8 ± 1.1 to -5.6 ± 0.8 cmH(2)O) and increase in VI(max) (from 354.1 ± 25.3 to 659.0 ± 71.8 μl/s). Nevertheless, passive P(CRIT) in leptin-treated mice did not differ significantly from that seen in nontreated ob(-)/ob(-) mice. The findings suggest that weight and leptin deficiency produced defects in upper airway neuromechanical control and that leptin reversed defects in active neuromuscular responses acutely without reducing mechanical loads.

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