Amniocentesis: A contemporary review

doi:10.5317/wjog.v5.i1.58

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World Journal of Obstetrics and Gynecology

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World J Obstet Gynecol. Feb 10, 2016; 5(1): 58-65
Published online Feb 10, 2016. doi: 10.5317/wjog.v5.i1.58

Amniocentesis: A contemporary review

Katherine Ann Connolly, Keith Arnold Eddleman

Katherine Ann Connolly, Keith Arnold Eddleman, Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai Hospital, New York, NY 10029, United States

Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.

Conflict-of-interest statement: No potential conflicts of interest. No financial support.

Correspondence to: Katherine Ann Connolly, MD, Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai Hospital, 5 East 98^th Street, Room 256, New York, NY 10029, United States. katherine.connolly@mssm.edu

Telephone: +1-212-2415681 Fax: +1-212-3487438

Received: August 1, 2015
Peer-review started: August 6, 2015
First decision: September 16, 2015
Revised: October 27, 2015
Accepted: December 13, 2015
Article in press: December 15, 2015
Published online: February 10, 2016
Processing time: 183 Days and 14.3 Hours

Core Tip

Core tip: Invasive testing remains the only way to provide comprehensive testing for chromosomal abnormalities. Despite availability of cell free fetal DNA testing, amniocentesis should still be offered to all women who desire complete genetic testing. Amniocentesis is also useful if intraamniotic infection is suspected, but the clinical picture is unclear. Additionally, when late preterm delivery is indicated, amniocentesis need not be used. There are, however, some instances when delivery timing is unclear and amniocentesis for fetal lung maturity may provide information to guide delivery timing. Amniocentesis is a relatively safe procedure. We counsel patients that technique has changed since the original studies in the 1970s and feel comfortable quoting a loss rate of 1/500-1/1000 based on contemporary data.