©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Obstet Gynecol. Feb 10, 2015; 4(1): 16-23
Published online Feb 10, 2015. doi: 10.5317/wjog.v4.i1.16
Published online Feb 10, 2015. doi: 10.5317/wjog.v4.i1.16
Hepatoma-derived growth factor expression as a prognostic marker in cervical cancer
Misa Song, Miki Tomoeda, Yu-Feng Jin, Chiaki Kubo, Hidenori Yoshizawa, Masanori Kitamura, Shigenori Nagata, Yasuhiko Tomita, Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan
Yukinobu Ohta, Shoji Kamiura, Department of Gynecology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan
Hideji Nakamura, Department of Internal Medicine, Nissay Hospital, Osaka 550-0012, Japan
Author contributions: Song M contributed to the study design, data interpretation and preparation of the final manuscript; Tomoeda M, Jin YF, Kubo C, Yoshizawa H, Kitamura M and Nagata S contributed to the histological and immunohistochemical analysis; Ohta Y and Kamiura S contributed to the clinical study procedures; Nakamura H contributed to the antibody preparation and immunohistochemical analysis; Tomita Y contributed to the study design and preparation of the final manuscript; all authors read and approved the final manuscript.
Supported by The Japan Society for the Promotion of Science, No. 21590412; and The Osaka Foundation for the Prevention of Cancer and Cardiovascular Diseases
Correspondence to: Yasuhiko Tomita, MD, PhD, Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537-8511, Japan. yasuhiko-tomita@umin.ac.jp
Telephone: +81-6-69721181 Fax: +81-6-69818336
Received: January 16, 2014
Peer-review started: January 17, 2014
First decision: February 13, 2014
Revised: October 29, 2014
Accepted: October 31, 2014
Article in press: November 3, 2014
Published online: February 10, 2015
Processing time: 391 Days and 18.9 Hours
Peer-review started: January 17, 2014
First decision: February 13, 2014
Revised: October 29, 2014
Accepted: October 31, 2014
Article in press: November 3, 2014
Published online: February 10, 2015
Processing time: 391 Days and 18.9 Hours
Core Tip
Core tip: Hepatoma-derived growth factor (HDGF) is a unique nuclear growth factor, playing an important role in the development and progression of carcinomas. Prognostic importance of HDGF expression has been reported in several cancers. In the present study, HDGF expression in cervical cancer was examined by immunohistochemistry, showing increased HDGF expression as a marker of deep invasion, lymphatic invasion, and lymph node metastasis. In addition, HDGF expression was an independent prognostic factor for overall survival.