Dahiya K, Dalal D, Malhotra V, Aggarwal S, Malik AK, Ghalaut VS, Dahiya P. Is nitric oxide level affected in postmenopausal women with hypothyroidism? World J Obstet Gynecol 2017; 6(3): 16-20 [DOI: 10.5317/wjog.v6.i3.16]
Corresponding Author of This Article
Kiran Dahiya, MD, Professor, Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana 124001, India. biochemistry.pgims@hry.nic.in
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Control Study
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Dahiya K, Dalal D, Malhotra V, Aggarwal S, Malik AK, Ghalaut VS, Dahiya P. Is nitric oxide level affected in postmenopausal women with hypothyroidism? World J Obstet Gynecol 2017; 6(3): 16-20 [DOI: 10.5317/wjog.v6.i3.16]
Kiran Dahiya, Deepika Dalal, Veena Singh Ghalaut, Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana 124001, India
Vani Malhotra, Department of Obstetrics and Gynecology, Pt. BD Sharma PGIMS, Rohtak, Haryana 124001, India
Sameer Aggarwal, Department of Medicine, Pt. BD Sharma PGIMS, Rohtak, Haryana 124001, India
Ashish Kumar Malik, Department of Psychiatry, Pt. BD Sharma PGIMS, Rohtak, Haryana 124001, India
Priya Dahiya, Department of Obstetrics and Gynecology, Rajshree Medical Research Institute, Bareilly, UP 243501, India
Author contributions: Dahiya K and Dalal D contributed equally to the work; Dahiya K, Dalal D, Malhotra V and Aggarwal S designed the research work; Malhotra V and Aggarwal S treated the patients; Dahiya K and Dalal D collected material and clinical data from patients; Dahiya K, Dalal D and Ghalaut VS performed the assays; Dalal D, Malik AK and Dahiya P analyzed data; Dahiya K, Dahiya P and Dalal D wrote the paper. Malhotra V, Aggarwal S, Malik AK and Ghalaut VS approved the final version of the manuscript.
Institutional review board statement: This work was part of MD thesis project of Dr. Deepika Dalal under supervision of Dr. Kiran Dahiya and co-supervision of Dr. Vani Malhotra and Dr. Sameer Aggarwal. It was duly reviewed and approved by Institutional PG Board of Studies.
Informed consent statement: Informed consent was obtained from all the subjects of the study.
Conflict-of-interest statement: None.
Data sharing statement: No additional data are available.
Correspondence to: Kiran Dahiya, MD, Professor, Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana 124001, India. biochemistry.pgims@hry.nic.in
Telephone: +91-98-96111985
Received: May 2, 2017 Peer-review started: May 10, 2017 First decision: May 25, 2017 Revised: June 25, 2017 Accepted: July 10, 2017 Article in press: July 11, 2017 Published online: August 10, 2017 Processing time: 75 Days and 24 Hours
ARTICLE HIGHLIGHTS
Research background
Hypothyroidism and menopause, both pose a risk to the cardiac health of women.
Research objectives
As suggested by literature that estrogen induced cardio protection might be mediated by release of nitric oxide (NO), this study was conducted to estimate and compare serum NO levels in postmenopausal women with and without hypothyroidism.
Research methods
NO was analyzed as nitrite colorimetrically in 30 postmenopausal hypothyroid and euthyroid females each.
Research results
A statistically significant decrease was observed in NO levels in postmenopausal hypothyroid females as compared to their euthyroid counterparts (P < 0.05).
Research conclusions
It may be concluded that cardiovascular health is compromised in postmenopausal women because of low estrogen, which is further deteriorated by hypothyroidism, indicated by lower NO.
Research perspectives
This research directs towards future perspectives in analyzing other endothelial function markers along with actual estimation of NO and its association with reproductive hormone levels in larger study groups.
