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Seward N, Garman E, Davies T, Hanlon C, MacBeth A, Stewart RC, Waqas A, Araya R, Lund C. The importance of social support and food insecurity in improving outcomes for perinatal depression: A causal mediation analysis of the AFFIRM-SA trial. J Affect Disord 2025; 380:552-560. [PMID: 40154807 DOI: 10.1016/j.jad.2025.03.159] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/09/2024] [Revised: 03/17/2025] [Accepted: 03/25/2025] [Indexed: 04/01/2025]
Abstract
BACKGROUND Understanding the mechanisms through which psychological interventions influence symptoms of perinatal depression can inform the development of interventions for improving maternal mental health. The AFFIRM-SA trial, conducted in an underserved settlement on the outskirts of Cape Town, was a task-shared psychological intervention designed to improve symptoms of perinatal depression. We aim to estimate indirect effects of mediators through which the AFFIRM-SA intervention reduced perinatal depressive symptoms. METHODS Interventional Effects, a robust causal inference framework, was used to decompose the total effect of randomisation to the intervention on symptoms of perinatal depression reducing by at least 40 % on the Edinburgh Postnatal Depression Scale (EPDS) at 12 months postpartum in women with complete data (n = 310), into the following indirect effects at three months postpartum: experienced violence, presence of moderate or severe levels of food, and mean levels of perceived social support. RESULTS Of the total effect of the intervention measured through the difference in EPDS scores improving by at least 40 % between treatment arms (mean difference in probability between intervention and control arm: 0.139, bias-corrected 95 % CI -0.056 to 0.224), 8 % was mediated through reduced levels of severe food insecurity (0.011; bias-corrected 95 % CI 0.003, 0.029) and 9 % through increased levels of perceived social support (0.012: bias-corrected 95 % CI: 0.001, 0.032). There was no evidence to support the mediating role of reduced levels of violence. LIMITATIONS The main limitation is the sample size (n = 310) which reduces the certainty of our findings where mediators are uncommon (e.g., domestic violence). CONCLUSIONS Our findings suggest that psychological interventions that combine psychological components with interventions that directly target social determinants of mental health (such as food insecurity and social support) could substantially improve perinatal depression.
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Affiliation(s)
- Nadine Seward
- Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
| | - Emily Garman
- Department of Psychiatry and Mental Health, Alan J Flisher Centre for Public Mental Health, University of Cape Town, South Africa
| | - Thandi Davies
- Department of Psychiatry and Mental Health, Alan J Flisher Centre for Public Mental Health, University of Cape Town, South Africa
| | - Charlotte Hanlon
- Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
| | - Angus MacBeth
- School of Health and Social Science, University of Edinburgh, Edinburgh, UK
| | - Robert C Stewart
- Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
| | - Ahmad Waqas
- Institute of Population Health, University of Liverpool, Liverpool, UK
| | - Ricardo Araya
- Centre for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
| | - Crick Lund
- Department of Psychiatry and Mental Health, Alan J Flisher Centre for Public Mental Health, University of Cape Town, South Africa; Centre for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
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Behl R. Judicial interface with perinatal depression in India: an empirical analysis and thematic review of published judgments. Arch Womens Ment Health 2025; 28:401-414. [PMID: 37987837 DOI: 10.1007/s00737-023-01391-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/31/2023] [Accepted: 10/24/2023] [Indexed: 11/22/2023]
Abstract
In the absence of health law policies focused on perinatal depression (PND) in India, it has primarily remained a biomedical research matter instead of being understood from the human rights perspective. Also, the interplay between PND and the Indian justice delivery system remains unexplored. Hence, it is imperative to understand the medico-legal milieu of PND through the lens of judicial interface with the facet of PND. Most popular Indian electronic legal databases were used to identify the judgments pronounced by the Indian Courts where the PND quotient was involved. The text of the resultant judgments was individually read to evaluate if if the subject claim were affected by PND quotient to fit the inclusion criteria. Using the inductive and latent thematic approach, the different emergent themes from the subject claims of every single judgment were used for developing codes. Myriad themes emerged out of the analysis, which helped identify how PND vastly impacts the justice delivery system in varied types of cases in India. Obliviousness and lack of awareness in Indian judiciary regarding PND, and its consequences was largely observed. Human rights violations were discerned owing to absence of perinatal mental health (PMH) services. This policy gap, in turn, results in absence of data regarding women affected by PND and about administered treatment (if any) for managing PND, and reduced empathy by the law enforcement agencies. The resultant themes depict the urgent and multidimensional benefits of introducing policies for PMH services, which will help create awareness about the human rights dimension of PND amongst the law enforcement agencies including the Indian judiciary, and police.
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Affiliation(s)
- Ritika Behl
- Symbiosis International (Deemed) University, Pune, India.
- Alliance School of Law, Alliance University, Bengaluru, India.
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Desalegn SY, Feleke AE, Germame BF, Samuel AW. Prevalence of anxiety and associated factors among pregnant women in East Africa: A systematic review and meta-analysis, 2023. Public Health 2025; 244:105759. [PMID: 40373543 DOI: 10.1016/j.puhe.2025.105759] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/23/2024] [Revised: 03/27/2025] [Accepted: 04/24/2025] [Indexed: 05/17/2025]
Abstract
OBJECTIVES This review aimed to assess the prevalence of anxiety among pregnant women in East Africa. Additionally, the review seeks to identify the associated risk factors contributing to anxiety during pregnancy within this region. STUDY DESIGN A systematic review and meta-analysis. METHODS A systematic review and meta-analysis were conducted to examine anxiety among pregnant women in East Africa. PubMed, HINARI, Google scholar, and direct Google were searched to retrieve relevant studies. The pooled magnitude of anxiety during pregnancy was estimated using DerSimonian and Laird's random-effects model. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines were used. Data were extracted in Microsoft Excel sheet and STATA/SE 17 was used for meta-analysis. Using Q and the I2 test, heterogeneity among the studies was assessed. Funnel plot and Egger's test were used to test the small study effect. RESULTS A total of 64 studies were initially identified and evaluated. Of these, ten eligible articles with 4023 participants were included. The overall pooled prevalence of anxiety in East Africa was 29 % (95 % CI; 17 %-40 %). CONCLUSIONS This review demonstrated the high prevalence of anxiety during pregnancy among East African women. and it was significantly associated with having intimate partner violence, primary education status, having unwanted pregnancy, unmarried marital status, poor social support, history of depression, and prim gravidity. It is highly recommended that mental health and maternity services be integrated.
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Affiliation(s)
- Selam Yibeltal Desalegn
- Department of Midwifery, School of Nursing and Midwifery, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
| | - Asres Eshetie Feleke
- Department of Midwifery, School of Nursing and Midwifery, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
| | - Betelhem Fekadu Germame
- Department of Psychiatry, School of Nursing and Midwifery, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
| | - Alemtsehay Wossen Samuel
- Department of Midwifery, School of Nursing and Midwifery, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
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Val A, Posse CM, Míguez MC. Risk Factors for Prenatal Anxiety in European Women: A Review. J Clin Med 2025; 14:3248. [PMID: 40364279 PMCID: PMC12072564 DOI: 10.3390/jcm14093248] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/31/2025] [Revised: 04/30/2025] [Accepted: 05/05/2025] [Indexed: 05/15/2025] Open
Abstract
Background: Prenatal anxiety is a common problem affecting a large number of women. The presence of anxiety during pregnancy is associated with adverse consequences for both the mother and the baby. The main objective of this review was to determine the risk factors associated with anxiety during pregnancy in European women. Specifically, we wanted to know if these factors are the same as those found in other continents and if they are similar to those associated with depression during this stage. Methods: A literature review was carried out on studies that were published in the last 10 years in the PsycInfo, Medline, and SCOPUS databases. Thirteen studies were selected for the purposes of this review. Results: Sociodemographic risk factors associated with a higher level of anxiety during pregnancy included having a lower educational level and socioeconomic status. Obstetric and pregnancy-related risk factors included having had complications during pregnancy. Having a history of mental health problems, low social support, high levels of stress, and being exposed to adverse life events were the most relevant psychological factors for presenting prenatal anxiety. Furthermore, these factors are largely common to those associated with prenatal anxiety in other continents of the world and to those associated with prenatal depression. Conclusions: This review shows that there are multiple factors that contribute to women experiencing prenatal anxiety. Most can be identified at the beginning of pregnancy, and some factors, such as psychological ones, are potentially modifiable. This underlines the importance of carrying out a proper screening for anxiety during pregnancy in order to prevent its onset or treat it appropriately. Furthermore, the fact that risk factors are common for both prenatal anxiety and depression implies that the same intervention could reduce the probability of the onset of both pathologies and the possible consequences associated with them.
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Affiliation(s)
| | | | - M. Carmen Míguez
- Faculty of Psychology, Department of Clinical Psychology and Psychobiology, Institute of Psychology (IPsiUS), University of Santiago de Compostela, Campus Vida, 15782 Santiago de Compostela, Spain; (A.V.); (C.M.P.)
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Mahamid S, Chasson M, Taubman-Ben-Ari O. Challenging Social Taboos in Early Caregiving - Assessing Maternal Intrusive Thoughts and Dissociative Experiences Among Arab Mothers. J Trauma Dissociation 2025; 26:452-468. [PMID: 40126134 DOI: 10.1080/15299732.2025.2481481] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/22/2024] [Accepted: 03/14/2025] [Indexed: 03/25/2025]
Abstract
The current investigation consists of two studies aimed at validating an Arabic version of the Maternal Disintegrative Responses Scale (A-MDRS), designed to evaluate maternal intrusive thoughts and dissociative experiences during early caregiving. The participants consisted of Arab mothers in Israel within 12 months post-childbirth. Study 1 (n = 243) assessed the factorial structure and reliability of the scale, and its correlation with maternal background variables. Study 2 (n = 195) further explored its factorial structure and reliability, as well as its construct validity, by examining associations with postpartum depression, maternal role satisfaction, and psychological flexibility. Confirmatory factor analyses in both studies supported a two-factor solution, demonstrating good reliability. In addition, Study 2 revealed a positive correlation between the A-MDRS factors and postnatal depression, and a negative association with maternal role satisfaction and psychological flexibility. The findings endorse the A-MDRS's value in identifying maternal disintegrative responses during the postpartum period, affirming its factorial structure and reliability.
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Affiliation(s)
- Samah Mahamid
- The Bob Shapell School of Social Work, Tel Aviv University, Tel Aviv, Israel
| | - Miriam Chasson
- The Louis and Gabi Weisfeld School of Social Work, Bar Ilan University, Ramat Gan, Israel
- Department of Psychiatry, Cambridge Health Alliance, Harvard Medical School, Cambridge, Massachusetts, USA
| | - Orit Taubman-Ben-Ari
- The Louis and Gabi Weisfeld School of Social Work, Bar Ilan University, Ramat Gan, Israel
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Chang YH, Chang SS, Lu JFR, Chiang TL. Socio-demographic, family, and health-related predictors of maternal mental health trajectories during eight years postpartum in a national cohort of 17,886 mothers in Taiwan. Soc Sci Med 2025; 373:117960. [PMID: 40157306 DOI: 10.1016/j.socscimed.2025.117960] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/06/2024] [Revised: 03/05/2025] [Accepted: 03/12/2025] [Indexed: 04/01/2025]
Abstract
BACKGROUND Previous studies on maternal postpartum mental health are limited by non-representative samples, a narrow focus on mental illness, and a lack of systematic examination of predictors for diverse mental health trajectories. We investigated maternal mental health trajectories during eight years postpartum and their socio-demographic, family, and health-related predictors in a large cohort of mothers in Taiwan. METHODS Participants were 17,886 mothers drawn from the Taiwan Birth Cohort Study (TBCS), a cohort study of a nationally representative sample of children born in Taiwan in 2005 and their parents. Maternal mental health was assessed at 6, 18, 36, 66, and 96 months postpartum using the Mental Component Summary (MCS) from the 36-item Short-Form Health Survey (SF-36) Taiwan version. We used group-based trajectory modeling to identify trajectory groups of maternal mental health and examined their predictors using multinomial logistic regression. RESULTS Five postpartum mental health trajectories were identified: persistently poor (6.7%), improving (12.1%), deteriorating (14.3%), persistently moderate (46.7%), and persistently good (20.1%), with the first two groups having the poorest mental health at six months postpartum. Immigrant status and higher household income were associated with favorable (i.e., improving, or persistently moderate or good) mental health trajectories, while low family function and poor general health at six months postpartum were associated with less favorable (i.e., deteriorating or persistently poor) trajectories. Among mothers with poor mental health at six months postpartum, being divorced or separated was additionally associated with persistently poor mental health. Among mothers with moderate mental health at six months postpartum, being a first-time mother was additionally associated with deteriorating mental health. CONCLUSION Our findings highlight distinct maternal mental health trajectories over eight years postpartum, with one in five mothers experiencing deteriorating or persistently poor mental health. Socio-demographic factors, family function, and early postpartum health were predictors of these trajectories.
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Affiliation(s)
- Yi-Han Chang
- Substance and Addiction Prevention Branch, Center for Healthy Communities, California Department of Public Health, 1616 Capitol Ave, Sacramento, CA, 95814, USA; Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, 111, Section 3, Xing-Long Road, Taipei, 11696, Taiwan
| | - Shu-Sen Chang
- Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, 111, Section 3, Xing-Long Road, Taipei, 11696, Taiwan; Institute of Health Behaviors and Community Sciences, College of Public Health, National Taiwan University, 17 Xuzhou Road, Taipei, 100, Taiwan; Global Health Program, College of Public Health, National Taiwan University, 17 Xuzhou Road, Taipei, 100, Taiwan; Population Health Research Center, College of Public Health, National Taiwan University, 17 Xuzhou Road, Taipei, 100, Taiwan.
| | - Jui-Fen Rachel Lu
- Department of Health Care Management and Graduate Institute of Management, College of Management, Chang Gung University, 259 Wenhua 1st Rd., Guishan Dist., Taoyuan City, 33302, Taiwan; Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou Branch, 5 Fu-Shin Street, Taoyuan, 333, Taiwan
| | - Tung-Liang Chiang
- Institute of Health Policy and Management, College of Public Health, National Taiwan University, 17 Xuzhou Road, Taipei, 100, Taiwan
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Girma B, Sibhat M, Getnet A, Teklehaimanot WZ, Mengstie LA, Gebeyehu MT, Nigussie J. Common mental disorders and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis. BMC Psychiatry 2025; 25:430. [PMID: 40296015 PMCID: PMC12039121 DOI: 10.1186/s12888-025-06880-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/08/2024] [Accepted: 04/17/2025] [Indexed: 04/30/2025] Open
Abstract
BACKGROUND Common mental disorders are the most common public health problems, especially in low and middle-income countries. The burden is high among pregnant women. However, the concern given to this problem is less and isn't assessed during the antenatal period. In Ethiopia, there was no summarized evidence about the problem in this particular population. Therefore, this systematic review and meta-analysis aimed to assess the pooled magnitude of common mental disorders among pregnant mothers and their associated factors in Ethiopia. METHODS We used the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines to write this review and meta-analysis. Only primary studies published in English were included. The Egger's test and funnel plot were done to assess the publication bias Heterogeneity was assessed by I2 and subgroup analysis was conducted to identify the source. A random effect model was used to perform the analysis. An association was declared with a pooled adjusted odds ratio with 95% CI. RESULT A total of 11 studies were included and the pooled magnitude of common mental disorders was 27.00 [95% CI: 20.47, 33.53]. Unplanned pregnancy [pooled AOR: 2.82 with 95% CI (2.23, 3.58)], intimate partner violence [pooled AOR: 2.81 with 95% CI (2.29, 3.46), substance use [pooled AOR: 2.97 with 95% CI (2.29, 3.85)], chronic disease [pooled AOR: 3.60; 95% CI (2.19, 5.91)], obstetric complications [pooled AOR: 2.78 with 95% CI (1.89, 4.07)] and family history of psychiatric illness [pooled AOR: 4.03 with 95% (2.58, 6.30)] were significant predictors for common mental disorders. CONCLUSION In this meta-analysis, the pooled magnitude of common mental disorders was high as compared to the global report. Substance use, chronic disease, unplanned pregnancy, intimate partner violence, having a history of obstetric complications, and a family history of psychiatric illness were significantly associated with common mental disorders. The Federal Ministry of Health should design a strategy that helps to assess the mental health of pregnant women during their antenatal care follow-up. Moreover, healthcare providers should focus on and support pregnant women who have the above factors.
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Affiliation(s)
- Bekahegn Girma
- Department of Pediatrics and Child Health Nursing, School of Nursing and Midwifery, College of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia.
| | - Migbar Sibhat
- Department of Nursing, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia
| | - Addisu Getnet
- Department of Midwifery, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia
| | - Wegayehu Zeneb Teklehaimanot
- Department of Pediatrics and Child Health Nursing, School of Nursing and Midwifery, College of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia
| | - Leweyehu Alemaw Mengstie
- Department of Pediatrics and Child Health Nursing, School of Nursing and Midwifery, College of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia
| | - Mohammed Tessema Gebeyehu
- Department of Pediatrics and Child Health Nursing, School of Nursing and Midwifery, College of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia
| | - Jemberu Nigussie
- School of Nursing and Midwifery, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia
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de Oliveira CVR, Bordignon SS, Martins RC, Blumenberg C, Martins-Silva T, Costa F, Cesar J, Springer P, de Mola CL. Trajectories of maternal depression, anxiety, stress, and child developmental milestones at 24 months. J Child Adolesc Ment Health 2025:1-15. [PMID: 40202424 DOI: 10.2989/17280583.2025.2452533] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/10/2025]
Abstract
Background: Literature suggests a link between maternal mental health and adverse child developmental outcomes. However, we do not know to what extent this is true in low and middle-income settings, and most studies do not explore mental health longitudinally since birth.Objective: We aimed to assess the association between maternal mental health and early child development outcomes in southern Brazil.Methods: We studied 992 mother-child pairs in a birth cohort from 2019 to 2022. We used standardised instruments to assess maternal depression, anxiety, and distress at different time points during the perinatal period. We used Group Based Trajectory Modelling to create maternal mental health trajectories. We assessed these trajectories associated with the child's social, language, cognitive, and motor development at 24 months using Poisson multiple regression models.Results: Children of mothers with elevated symptoms of depression experienced an 80% [RR = 1.80; 95%CI(1.19-2.71)] increase in language delays, 23% [RR = 1.23; 95%CI(1.01-1.51)] in cognitive delays, and 40% [RR = 1.40; 95%CI(1.07-1.83)] in motor delays. Children of mothers experiencing increasing symptoms of anxiety to moderate levels had 38% [RR = 1.38' 95%CI(1.07-1.82)] more language delays and 20% [RR = 1.20; 95%CI(1.05-1.38)] more cognitive delays. Low subjective distress led to 54% [RR = 1.54; 95%CI(1.15-2.05)] more language delays.Conclusion: Our findings underscore the effect of maternal mental health on child developmental outcomes among this sample in southern Brazil.
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Affiliation(s)
| | | | - Rafaela Costa Martins
- GPIS Grupo de Pesquisa e Inovação em Saúde, Universidade Federal do Rio Grande, Rio Grande, Brazil
- Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande, Brazil
- Causale consultoria, Pelotas, Brazil
| | - Cauane Blumenberg
- GPIS Grupo de Pesquisa e Inovação em Saúde, Universidade Federal do Rio Grande, Rio Grande, Brazil
- Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande, Brazil
- Causale consultoria, Pelotas, Brazil
| | - Thais Martins-Silva
- GPIS Grupo de Pesquisa e Inovação em Saúde, Universidade Federal do Rio Grande, Rio Grande, Brazil
- Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande, Brazil
| | - Francine Costa
- GPIS Grupo de Pesquisa e Inovação em Saúde, Universidade Federal do Rio Grande, Rio Grande, Brazil
- Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande, Brazil
| | - Juraci Cesar
- Postgraduate Program in Public Health, Federal University of Rio Grande, Rio Grande, Brazil
| | - Paul Springer
- Virginia Tech University, Blacksburg, VA 24061, United States of Ameerica
| | - Christian Loret de Mola
- GPIS Grupo de Pesquisa e Inovação em Saúde, Universidade Federal do Rio Grande, Rio Grande, Brazil
- Postgraduate Program in Public Health, Federal University of Rio Grande, Rio Grande, Brazil
- Department, Universidad Científica del Sur, Lima, Peru
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Wagner GJ, Ghosh-Dastidar B, Gwokyalya V, Faherty LJ, Beyeza-Kashesya J, Nakku J, Nabitaka LK, Akena D, Nakigudde J, Ngo V, McBain R, Lukwata H, Kyohangirwe L, Mukasa B, Wanyenze RK. Effects of M-DEPTH model of depression care on maternal depression, functioning, and HIV care adherence, and infant developmental over eighteen months post-partum: results from a cluster randomized controlled trial. BMC Pregnancy Childbirth 2025; 25:400. [PMID: 40188047 PMCID: PMC11971773 DOI: 10.1186/s12884-025-07443-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/27/2023] [Accepted: 03/09/2025] [Indexed: 04/07/2025] Open
Abstract
BACKGROUND Perinatal depression is associated with poor outcomes related to HIV care adherence, maternal functioning, and early child development. We examined whether the M-DEPTH (Maternal Depression Treatment in HIV) depression care model-including antidepressant therapy and individual problem-solving therapy-and depression alleviation would affect improvement in each of these outcome domains. METHODS A sample of 354 pregnant women living with HIV (WLH) with at least mild depressive symptoms (177 in each of intervention and usual care control arms) enrolled in a cluster randomized controlled trial across eight antenatal care clinics in Uganda and had a live birth delivery. Longitudinal mixed effects models were used to examine survey data and chart-abstracted HIV viral load and antiretroviral pharmacy refill data collected at baseline and months 2, 6, 12 and 18 post-partum. RESULTS 69% had clinical depression at enrollment; 70% of women in the intervention group (including 96% of those with clinical depression) received depression treatment. Mixed-effects longitudinal regression analysis showed (1) strong effects of the intervention on maternal depression at each post-partum follow-up assessment; and (2) moderate effects of the intervention and reduced depression on maternal functioning (self-care and infant care, in particular). However, there was little evidence of effects of the intervention and depression reduction on early child development, maternal viral suppression, or ART adherence. CONCLUSION These findings suggest that depression care for pregnant WLH is important for maternal mental health, but it also helps women to better manage parenting and care for their infant. Supplementary interventions may be needed to impact early child development. TRIAL REGISTRATION The trial was registered with the NIH Clinical Trial Registry (clinicaltrials.gov: NCT03892915) on 27/03/2019.
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Affiliation(s)
- Glenn J Wagner
- RAND Corporation, 1776 Main Street, Santa Monica, CA, 90407, USA.
| | | | | | - Laura J Faherty
- RAND Corporation, 1776 Main Street, Santa Monica, CA, 90407, USA
- Boston University School of Medicine, Boston, MA, USA
| | - Jolly Beyeza-Kashesya
- Mulago Specialized Women and Neonatal Hospital, Kampala, Uganda
- School of Medicine, Makerere University, Kampala, Uganda
| | - Juliet Nakku
- Butabika National Referral Mental Hospital, Kampala, Uganda
| | | | - Dickens Akena
- College of Health Sciences, Makerere University, Kampala, Uganda
| | - Janet Nakigudde
- College of Health Sciences, Makerere University, Kampala, Uganda
| | - Victoria Ngo
- RAND Corporation, 1776 Main Street, Santa Monica, CA, 90407, USA
- Graduate School of Public Health and Health Policy, City University of New York, New York, USA
| | - Ryan McBain
- RAND Corporation, 1776 Main Street, Santa Monica, CA, 90407, USA
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10
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Wollie AM, Usher K, Rice K, Islam MS. Health Professionals' Attitudes Towards Traditional Healing for Mental Illness: A Systematic Review. Int J Ment Health Nurs 2025; 34:e70043. [PMID: 40256944 PMCID: PMC12010464 DOI: 10.1111/inm.70043] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/10/2024] [Revised: 01/09/2025] [Accepted: 03/28/2025] [Indexed: 04/22/2025]
Abstract
Combining modern treatments with traditional healing approaches has been proposed as one way to address mental health problems, especially in low-income countries where the costs of pharmaceuticals often prevent or reduce their use. Despite health professionals' involvement being crucial for the integration of this approach, their involvement has been limited to date. This systematic review is designed to explore the attitudes of health professionals towards traditional healing practices for mental illness. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 guidelines were followed. The studies were identified from Scopus, EMBASE, PubMed, PsycINFO, and the Web of Sciences. The qualities of the included articles were assessed using the Mixed Method Appraisal Tool (MMAT) Version 2018, and mixed-method synthesis was used to narrate the results. Of the 2115 identified articles, 36 were included in the data synthesis. From the extracted data, health professionals had negative, mixed, and positive views towards traditional healing approaches for mental illness. Their negative attitude towards traditional healing approaches were due to their concerns that traditional healing may cause harm to service users, and they have no trust in the scientific basis, education, or practices of healers. Despite the fact that it is crucial for healthcare professionals to comprehend the cultural backgrounds of those receiving mental health services in order to offer care appropriately, health professionals' negative and mixed attitudinal expressions towards traditional healing approaches limit their involvement. This might be improved by identifying barriers from the perspective of practitioners and creating culturally appropriate guidelines for communication and referral between traditional healing approaches and biomedical care.
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Affiliation(s)
- Alemayehu Molla Wollie
- School of Health, Faculty of Medicine and HealthUniversity of new EnglandArmidaleNew South WalesAustralia
- Department of Psychiatry, College of Medicine and Health SciencesInjibara UniversityInjibaraEthiopia
| | - Kim Usher
- School of Health, Faculty of Medicine and HealthUniversity of new EnglandArmidaleNew South WalesAustralia
| | - Kylie Rice
- School of Psychology, Faculty of Medicine and HealthUniversity of New EnglandArmidaleNew South WalesAustralia
| | - Md. Shahidul Islam
- School of Health, Faculty of Medicine and HealthUniversity of new EnglandArmidaleNew South WalesAustralia
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Alnaji N, Louis B, Bagenda D. Understanding risk factors for perinatal distress in Syrian refugee mothers: insights from Lebanon. Arch Womens Ment Health 2025; 28:271-278. [PMID: 39627413 DOI: 10.1007/s00737-024-01544-z] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/13/2024] [Accepted: 11/26/2024] [Indexed: 04/25/2025]
Abstract
PURPOSE The perinatal period is a critical phase in a woman's life, marked by unique mental health challenges. This study focuses on Syrian mothers in Lebanon, a vulnerable population often exposed to displacement and conflict-related stressors. The aim is to identify risk factors for perinatal distress, including symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD), among Syrian mothers within one year of giving birth. METHODS Data collection included quantitative assessments using the Refugee Health Screener-13 (RHS-13), and qualitative insights from in-depth interviews. The assessment period was extended to cover the year following childbirth to provide a broader perspective on perinatal distress. RESULTS The study revealed significant risk factors, specifically a history of mental illness and chronic disease. While maternal age and number of children were considered potential risk factors, they were not statistically significant in the quantitativeanalysis but were highlighted in the qualitative interviews. CONCLUSIONS This research offers valuable insights for healthcare providers, policymakers, and organizations working with Syrian refugee women in Lebanon. Addressing these risk factors can improve mental health outcomes for perinatal women affected by war and displacement, underscoring the need for proactive mental health screening during pregnancy and postpartum.
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Affiliation(s)
- Nada Alnaji
- University of Nebraska Medical Center, Omaha, NE, USA.
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12
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Xu J, Xiao Y, Li F, Cui Y, Shi C, Shi J, Yu C, Qi S, Lu C, Li G, Jiang F. Prevalence and impact of parental co-morbid anxiety and depression during the first 2 years postpartum in China. J Affect Disord 2025; 374:63-71. [PMID: 39800070 DOI: 10.1016/j.jad.2025.01.041] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/16/2024] [Revised: 11/28/2024] [Accepted: 01/09/2025] [Indexed: 01/15/2025]
Abstract
BACKGROUND Parental postpartum co-morbid anxiety and depression negatively impact personal well-being, family dynamics, and child developmental outcomes. This study investigates the prevalence of co-morbid anxiety and depression in both mothers and fathers during the first 2 years postpartum in China, and to explore its associations with parental family support, maternal health-related quality of life (HRQoL), and child development. METHODS This cross-sectional study was conducted in China, involving families with children aged 0-2 years who participated in community child health care. Data were collected via questionnaires administered to parents by pediatricians and nurses at community health service (CHS) centers. Path analysis was utilized to test the hypothesized model, which links parental co-morbid anxiety and depression to parental family support, maternal HRQoL, and child development. RESULTS A total of 2073 pairs of both parents who completed the survey were included in the final analyses. The prevalence of maternal and paternal co-morbid anxiety and depression, was 5.7 % and 4.4 %, respectively. Among mothers, the prevalence ranged from 4.3 % to 6.5 % within the first 6 months, and 7.9 % in the second year. After adjusting for covariates, severe family dysfunction was significantly associated with maternal and paternal co-morbid anxiety and depression. The path analysis showed that maternal co-morbid anxiety and depression were directly associated with child development and maternal HRQoL. CONCLUSIONS These findings highlight the importance of prioritizing family support, addressing both depression and anxiety, involving both parents and extending support beyond the first year postpartum.
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Affiliation(s)
- Jianing Xu
- School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China
| | - Yuyin Xiao
- School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Freeman Spogli Institute for International Studies, Stanford University, Stanford, CA, USA
| | - Feifei Li
- China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China
| | - Yujie Cui
- China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China
| | - Chenshu Shi
- Institute of Healthy Yangtze River Delta, Shanghai Jiao Tong University, Shanghai, China
| | - Jiaqi Shi
- School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China
| | - Chenhao Yu
- School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China
| | - Shaofang Qi
- China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China
| | - Chunling Lu
- Division of Global Health Equity, Brigham and Women's Hospital, Boston, MA, USA; Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA
| | - Guohong Li
- School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China; Institute of Healthy Yangtze River Delta, Shanghai Jiao Tong University, Shanghai, China; Department of Developmental and Behavioral Pediatrics and Pediatric Translational Medicine Institute and Shanghai Key Laboratory of Child Brain and Development, National Children's Medical Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
| | - Fan Jiang
- Department of Developmental and Behavioral Pediatrics and Pediatric Translational Medicine Institute and Shanghai Key Laboratory of Child Brain and Development, National Children's Medical Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China.
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13
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Naseem H, Park S, Rowther AA, Atif N, Rahman A, Perin J, Zaidi A, Malik A, Surkan PJ. Perinatal Intimate Partner Violence and Maternal-Infant Bonding in Women With Anxiety Symptoms in Pakistan: The Moderating Role of Breastfeeding. JOURNAL OF INTERPERSONAL VIOLENCE 2025; 40:1934-1958. [PMID: 39189042 DOI: 10.1177/08862605241271364] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 08/28/2024]
Abstract
Intimate partner violence (IPV) during the perinatal period can negatively affect both a woman's health and the bonding with her infant. Research on IPV among pregnant women experiencing psychological distress in South Asia is limited. We examined associations between perinatal exposure to IPV and postnatal maternal-infant bonding in Pakistani women with symptoms of anxiety and assessed if breastfeeding practices moderated these associations. Postnatal data were collected from 720 Pakistani women who reported at least mild levels of anxiety symptoms in pregnancy. We performed Poisson regression with robust variance analyses to examine the associations between IPV during pregnancy or within 6 weeks after delivery (i.e., the perinatal period) and maternal-infant bonding. Interaction terms between IPV and breastfeeding practices were included in the analytic models to examine the moderating effects. About 27% of women were exposed to at least one type of perinatal IPV. Women who were exposed to IPV were more likely to have moderate to severe postpartum anxiety (n = 57, 28.9% of IPV-exposed women), compared to those without IPV (n = 65, 12.4% of unexposed women; p value < .001). Compared to women not reporting IPV, women exposed to any IPV showed a 38% increase in Postpartum Bonding Questionnaire scores, suggesting higher likelihood of impaired bonding (risk ratio [RR] = 1.38, 95% confidence interval [CI] [1.21, 1.56]). Among women who initiated breastfeeding later than 1 hr post-delivery, IPV was associated with impaired bonding (RR = 1.09, 95% CI [1.06, 1.20]), whereas no association was present for women who initiated breastfeeding within 1 hr (RR = 1.03, 95% CI [0.98, 1.08]). In addition to the efforts to reduce IPV, encouraging IPV-exposed women to adhere to the breastfeeding guidelines (e.g., early breastfeeding) may enhance maternal-infant bonding.
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Affiliation(s)
- Hina Naseem
- Human Development Research Foundation, Rawalpindi, Pakistan
| | - Soim Park
- Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
| | | | - Najia Atif
- Human Development Research Foundation, Rawalpindi, Pakistan
| | | | - Jamie Perin
- Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
| | - Ahmed Zaidi
- Human Development Research Foundation, Rawalpindi, Pakistan
| | - Abid Malik
- Human Development Research Foundation, Rawalpindi, Pakistan
- Health Services Academy, Islamabad, Pakistan
| | - Pamela J Surkan
- Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
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14
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Li Y, Yu H, Shen K, Long J. Women's mental health during late pregnancy: A survey conducted in Shandong Province, China. FORTSCHRITTE DER NEUROLOGIE-PSYCHIATRIE 2025; 93:128-137. [PMID: 38959946 PMCID: PMC12020716 DOI: 10.1055/a-2337-4336] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/20/2023] [Accepted: 05/28/2024] [Indexed: 07/05/2024]
Abstract
BACKGROUND The study aimed to investigate the general mental health status and its associated factors in women during late pregnancy. The objective was to provide a scientific basis for developing psychological interventions tailored to this specific population. METHODS The research was conducted from May 2021 to July 2022, involving the recruitment of 200 women attending maternal and child health clinics for their late-pregnancy checkups. Data collection was carried out using a comprehensive approach, involving several validated tools. The participants completed a general demographic and sociological questionnaire along with four standardized psychological assessment scales: the 12-item General Health Questionnaire (GHQ-12), the Athens Insomnia Scale (AIS-8), the Generalized Anxiety Disorder 7 (GAD-7), and the 9-question Patient Health Questionnaire (PHQ-9). A total of 200 valid questionnaires were collected for analysis. RESULTS The study revealed that the overall prevalence of positive detection of general mental health problems in women during late pregnancy was 11%. Significant differences were observed in the positive detection rate of general mental health status based on various factors such as the quality of relationships with husbands, pregnancy intentions, insomnia, anxiety, and depression (p<0.01). Furthermore, participants with general mental health problems displayed notably higher scores on the AIS-8, PHQ-9, and GAD-7 scales compared to those without such problems (p<0.01). Regression analysis indicated that pregnancy intention and PHQ-9 scores were influential factors affecting the general mental health of women during late pregnancy (p<0.05). CONCLUSION The study highlights high rates of general mental health problems during late pregnancy, with unplanned pregnancy and elevated depression scores as key risk factors. Regular mental health screening and targeted interventions are essential to support women during this critical period and enhance the well-being of both mothers and babies.
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Affiliation(s)
- Yijie Li
- Psychological Clinic, Tianjin Anding Hospital, Tianjin,
China
| | - Huihui Yu
- Department of outpatient psychology, Tianjin Anding
Hospital, Tianjin, China
| | - Kaifang Shen
- Department of Maternal Medicine, Linyi Maternal and Child Health
Hospital, Linyi, China
| | - Jing Long
- Tianjin Anding Hospital, Tianjin, China
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Salomão Lopes C, Carvalho RJV, da Silva TL, Barros HLS, Costa LVS, Mota DCAM, Barbosa BF, Vieira LS, de Araújo TM, Costa AR, Awoyinka RO, Mineo TWP, Diniz ALD, Mineo JR. Pregnant Women Chronically Infected by Toxoplasma gondii with Depressive Disorder: Differential Modulation of Pro-Inflammatory and Anti-Inflammatory Cytokines. Pathogens 2025; 14:330. [PMID: 40333139 PMCID: PMC12030257 DOI: 10.3390/pathogens14040330] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/02/2025] [Revised: 03/22/2025] [Accepted: 03/26/2025] [Indexed: 05/09/2025] Open
Abstract
Depressive disorder during pregnancy is a common condition, affecting approximately 10-15% of pregnant women, and is associated with adverse pregnancy outcomes such as inadequate prenatal care, substance abuse, and fetal growth restriction. Beyond neurotransmitter disturbances, increasing evidence suggests that infectious agents may play a role in the pathophysiology of depression through immune system modulation. Toxoplasma gondii infection has been linked to various mental disorders in the general population, including depression and anxiety. This study aimed to investigate whether depressive disorder during pregnancy is associated with chronic T. gondii infection by analyzing cytokine levels involved in inflammatory response modulation. Serum levels of TNF, IFN-γ, TGF-β1, IL-6, IL-8, IL-10, and MIF were measured in 79 pregnant women (18-40 years old) during the third trimester of an uncomplicated pregnancy. Participants were divided into four groups: Group I-depressive disorder and T. gondii seropositive (n = 19); Group II-no depressive disorder and T. gondii seropositive (n = 20); Group III-depressive disorder and T. gondii seronegative (n = 20); and Group IV-no depressive disorder and T. gondii seronegative (n = 20). Depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS) during routine prenatal visits, and blood samples were collected during standard prenatal examinations. Significant differences in cytokine levels were observed among the study groups. Notably, the group with both depressive disorder and chronic T. gondii infection exhibited a distinct cytokine profile characterized by significantly elevated TNF, IL-6, and IL-10 levels and significantly reduced IL-8 and MIF levels compared to the other groups. These findings suggest that pregnant women with depressive disorder and chronic T. gondii infection exhibit an altered balance of pro- and anti-inflammatory cytokines. This is the first study to investigate the association between serum cytokine levels, depressive disorder, and chronic T. gondii infection in pregnant women. Further research is needed to evaluate the potential of these immunobiomarkers as diagnostic tools or for monitoring therapeutic and prognostic strategies in this context.
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Affiliation(s)
- Carolina Salomão Lopes
- Laboratory of Immunoparasitology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (C.S.L.); (R.J.V.C.); (T.L.d.S.); (H.L.S.B.); (L.V.S.C.); (R.O.A.); (T.W.P.M.)
| | - Ricardo José Victal Carvalho
- Laboratory of Immunoparasitology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (C.S.L.); (R.J.V.C.); (T.L.d.S.); (H.L.S.B.); (L.V.S.C.); (R.O.A.); (T.W.P.M.)
- Clinical Department, Faculty of Medicine, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (L.S.V.); (T.M.d.A.); (A.R.C.)
| | - Tamires Lopes da Silva
- Laboratory of Immunoparasitology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (C.S.L.); (R.J.V.C.); (T.L.d.S.); (H.L.S.B.); (L.V.S.C.); (R.O.A.); (T.W.P.M.)
| | - Heber Leão Silva Barros
- Laboratory of Immunoparasitology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (C.S.L.); (R.J.V.C.); (T.L.d.S.); (H.L.S.B.); (L.V.S.C.); (R.O.A.); (T.W.P.M.)
| | - Lucas Vasconcelos Soares Costa
- Laboratory of Immunoparasitology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (C.S.L.); (R.J.V.C.); (T.L.d.S.); (H.L.S.B.); (L.V.S.C.); (R.O.A.); (T.W.P.M.)
| | - Danielly Christine Adriani Maia Mota
- Laboratory of Immunoparasitology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (C.S.L.); (R.J.V.C.); (T.L.d.S.); (H.L.S.B.); (L.V.S.C.); (R.O.A.); (T.W.P.M.)
| | - Bellisa Freitas Barbosa
- Laboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil;
| | - Luan Souza Vieira
- Clinical Department, Faculty of Medicine, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (L.S.V.); (T.M.d.A.); (A.R.C.)
| | - Talyene Marques de Araújo
- Clinical Department, Faculty of Medicine, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (L.S.V.); (T.M.d.A.); (A.R.C.)
| | - Alírio Resende Costa
- Clinical Department, Faculty of Medicine, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (L.S.V.); (T.M.d.A.); (A.R.C.)
| | - Ruth Opeyemi Awoyinka
- Laboratory of Immunoparasitology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (C.S.L.); (R.J.V.C.); (T.L.d.S.); (H.L.S.B.); (L.V.S.C.); (R.O.A.); (T.W.P.M.)
| | - Tiago Wilson Patriarca Mineo
- Laboratory of Immunoparasitology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (C.S.L.); (R.J.V.C.); (T.L.d.S.); (H.L.S.B.); (L.V.S.C.); (R.O.A.); (T.W.P.M.)
| | - Angélica Lemos Debs Diniz
- Gynecology and Obstetrics Department, Faculty of Medicine, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil;
| | - José Roberto Mineo
- Laboratory of Immunoparasitology, Department of Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia 380405-317, MG, Brazil; (C.S.L.); (R.J.V.C.); (T.L.d.S.); (H.L.S.B.); (L.V.S.C.); (R.O.A.); (T.W.P.M.)
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16
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Akkineni R, Ganjekar S, Satyanarayana V, Kondapuram N, Tiwari K, Medisetti S, Padmaja S, Karnan RV, Chandra PS. The impact of perinatal mental health training on knowledge and practice of primary care physicians: a systems strengthening initiative in Telangana, India. BMC PRIMARY CARE 2025; 26:88. [PMID: 40158152 PMCID: PMC11954265 DOI: 10.1186/s12875-025-02782-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Subscribe] [Scholar Register] [Received: 08/19/2024] [Accepted: 03/10/2025] [Indexed: 04/01/2025]
Abstract
BACKGROUND In India, despite the high prevalence of perinatal mental health (PMH) conditions most primary care physicians (PCPs) have inadequate knowledge and skills to identify and provide appropriate interventions. The Health and Family Welfare Department of Telangana, India, partnered with the United Nations Children's Fund (UNICEF) and the Perinatal Mental Health service of the National Institute of Mental Health and Neurosciences to address this gap. The initial step in integrating PMH into the Maternal and child health (MCH) program involved training PCPs. This study aimed to outline the knowledge improvements regarding PMH among PCPs after the training. METHODS The training, conducted from June to January 2023-2024 across 30 districts, employed various interactive and reflective educational methods. Pre and post-training assessments evaluated knowledge enhancement and skill development, focusing on identifying perinatal anxiety and depression, assessing severity, recognizing risk factors, identifying the need for referrals, and rational psychopharmacology. This study aimed to assess the impact of training on improving knowledge and skills among PCPs which would influence perinatal mental health service delivery in Telangana. RESULTS Out of 863 PCPs in the 30 districts, 465 (53.8%) were able to complete the one-day training. Valid pre and post-training responses were available for 374 PCPs. A comparison of pre and post-training scores showed improvement in knowledge in a mean number of risk factors identified (pre: 3.05, post: 5.4; p < 0.001), ability to recognize depression (pre: 2.75, post: 4.33; p < 0.001) and anxiety symptoms (pre: 4.16, post: 6.08; p < 0.001), assess the severity of depression (pre: 0.46, post: 0.85; p < 0.001) and anxiety (pre: 0.57, post: 0.98, p < 0.001), safe medication use during pregnancy (pre: 0.89, post: 2.18;p < 0.001), and during breastfeeding (pre: 1.07, post: 2.13; p < 0.001) and identifying the need for referral to a psychiatrist (pre: 1.90, post: 3.13; p = 0.003). CONCLUSION The one-day training for PCPs enhanced knowledge across various PMH domains. However, studies with follow-up data are necessary to assess the retention of this knowledge and skills related to case identification and referrals. Such studies will provide a more comprehensive evaluation of the effectiveness of the training program.
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Affiliation(s)
| | | | | | | | | | | | - S Padmaja
- Maternal Health and Nutrition, Health Services, Hyderabad, India
| | - R V Karnan
- IAS, DMHS Campus, Sultan Bazar, Koti, Hyderabad, India
| | - Prabha S Chandra
- Department of Psychiatry, NIMHANS, Hosur Road, Bengaluru, India.
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17
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Tessema M, Abera M, Birhanu Z. Improving postnatal social support using antenatal group-based psychoeducation: a cluster randomized controlled trial. Front Glob Womens Health 2025; 6:1510725. [PMID: 40225206 PMCID: PMC11986638 DOI: 10.3389/fgwh.2025.1510725] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/13/2024] [Accepted: 03/03/2025] [Indexed: 04/15/2025] Open
Abstract
Background Inadequate social support is the predominant cause of postnatal depression, which needs to be promoted through interventions. The objective of this study was to investigate the effect of antenatal group-based psychoeducation on improving postnatal social support. Methods The trial design was a cluster randomized controlled trial. The study was conducted on 32 non-adjusted health centers (clusters) among 550 pregnant women. Using simple randomization, health centers were randomized into 16 intervention and 16 control groups. The intervention group received both standard prenatal care and group-based psychoeducation sessions, whereas the control group received standard prenatal care alone. The study included all pregnant women who were between 12 and 20 weeks gestation and had a Patient Health Questionnaire-9 <10 level of depression. We used a functional social support questionnaire in a face-to-face interview to assess social support at 12-20 weeks of gestation and 6 weeks postpartum. An intention-to-treat analysis was done. We used relative risk and a mixed-effects multilevel logistic regression for data analysis. Result Out of 550 enrolled pregnant women, end-line data were collected from 511 participants, with an overall end-line response rate of 92.9%. Statistical analysis revealed that the intervention resulted in a substantial difference in all dimensions of social support between arms, although no difference was detected at baseline. As compared to that in controls, the total postnatal social support in the intervention clusters was considerably higher [190 (66.4%) vs. 88 (33.3%)], P = 0.001). Mothers who were under the intervention arms and received antenatal group-based psychoeducation were 2.04 times more likely to have postnatal social support (RR = 2.044, 95% CI: 1.684-2.481) compared to those who were under the control arms and received the usual care. Finally, mixed-effect analysis indicates that after adjusting for individual and community-level variables, the final model shows the intervention increased the total social support by 3.61 (AOR = 3.61, 95% CI: 2.14-6.09). Conclusion The implementation of antenatal group-based psychoeducation intervention resulted in a statistically significant effect in improving postnatal social support. This intervention approach must therefore be implemented and promoted in maternal healthcare services. Clinical Trial Registration https://pactr.samrc.ac.za/, identifier (PACTR 202203616584913).
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Affiliation(s)
- Marta Tessema
- School of Midwifery, Institute of Health, Jimma University, Jimma, Ethiopia
| | - Muluemebet Abera
- Department of Population and Family Health, Faculty of Public Health, Jimma, Ethiopia
| | - Zewdie Birhanu
- Department of Health, Behavior and Society, Faculty of Public Health, Jimma, Ethiopia
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18
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Laughlin HM, Khan K, Rashid F, Scarbrough A, Bick JR. Social and Economic Correlates of Prenatal Depression in Rural Bangladeshi Women. Matern Child Health J 2025:10.1007/s10995-025-04087-6. [PMID: 40148712 DOI: 10.1007/s10995-025-04087-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 03/04/2025] [Indexed: 03/29/2025]
Abstract
OBJECTIVE Prevalence rates of perinatal depression are especially high among women living in lower-middle-income countries (LMICs) when compared to higher-income countries. This is especially true for women living in Bangladesh, an LMIC in South Asia, a country that has limited mental health infrastructure and high rates of poverty. Women living in rural, impoverished communities in Bangladesh have been identified as being at high risk for prenatal depression. However, there is limited understanding of variability of prevalence rates across rural communities. To address this gap in understanding, we examined prevalence rates and correlates of prenatal depression among women living in two rural Bangladesh communities, Matlab and Ariahizar. METHODS During a prenatal health care visit, 60 women in two rural communities in Bangladesh, completed a survey battery asking about household income, education, depression symptoms, autonomy over household technology, and financial decision-making ability. RESULTS On average, prenatal depression was experienced by 31.6%, of women enrolled in this study, although rates varied significantly across communities. Around 50% of all women in the higher-risk, more underserved, Arihaizar community experienced clinically significant symptoms of prenatal depression in comparison with only 13.3% of women who experienced clinically significant levels of prenatal depression in Matlab, a higher resourced rural community. Across both communities, perceived autonomy and independence (based on reports of having control over resources in the home) were associated with lower depression symptoms. CONCLUSIONS FOR PRACTICE Prevalence of prenatal depression is highest in the most underserved communities. Additionally, we found preliminary associations between women's autonomy and depression during pregnancy.
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Affiliation(s)
- H M Laughlin
- Department of T.I.M.E.S/Psychology, University of Houston, Houston, TX, USA
| | - K Khan
- Department of Public Health, Sam Houston State University, Huntsville, TX, USA
| | - F Rashid
- Department of Public Health, Sam Houston State University, Huntsville, TX, USA
| | - A Scarbrough
- Department of Public Health, Sam Houston State University, Huntsville, TX, USA
| | - J R Bick
- Department of T.I.M.E.S/Psychology, University of Houston, Houston, TX, USA.
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19
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Holmes L, Bitew T, Haile A, Van Lith LM, Burgess S, Vandermark J, Babalola S, Amare H, Tilahun A, Shattuck D, Hendrickson ZM. Mothers Time: A Cluster Randomized Controlled Trial of the Effects of a Community-Based Cognitive Behavioral Therapy Intervention on Postpartum Mental Health and Family Planning in Northwest Ethiopia. Stud Fam Plann 2025; 56:9-39. [PMID: 40163252 DOI: 10.1111/sifp.70000] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/02/2025]
Abstract
Depression and anxiety symptoms are associated with increased unmet need for family planning (FP) postpartum, yet solutions promoting the integration of mental health into FP service settings remain scarce. The aims of this study were to quantitatively examine the immediate and longer term effects of participation in a group-based cognitive behavioral therapy (CBT) intervention called Mothers Time on (1) symptoms of depression and anxiety, (2) the use of a modern family planning method, and (3) intermediate FP-related factors among postpartum women in Ethiopia. Building from lessons learned during a feasibility study, we implemented a cluster randomized controlled design, with structured interviews delivered before (baseline), immediately following (endline), and fourxst months after implementation of the intervention (follow-up). A total of 302 postpartum women were recruited from 10 health clusters in northwest Ethiopia. In comparison to control clusters where participants received standard of care, intervention clusters showed significantly greater reductions in symptoms for both depression and anxiety from baseline to follow-up. Modern FP use also increased significantly more in intervention clusters as compared to control clusters from baseline to follow-up. Results suggest that more holistic FP services that consider postpartum mental health can both reduce postpartum depression and anxiety and support women in fulfilling their reproductive intentions.
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20
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Do HP, Dunne MP, Vo TV, Nguyen LH, Luong-Thanh BY, Valdebenito S, Baker PRA, Tran BX, Hoang TD, Eisner M. Applying the WHO INSPIRE Framework to Ending Violence Against Pregnant Women and Unborn Children: A Case Study in Vietnam. Violence Against Women 2025; 31:813-840. [PMID: 38380997 DOI: 10.1177/10778012241230324] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/22/2024]
Abstract
This article adapted the INSPIRE framework, developed by the World Health Organization to prevent violence against children, to the systematic analysis of city-level healthcare services for pregnant women who experienced intimate partner violence. A mixed-methods study conducted in-depth interviews with 22 health and social care professionals and 140 pregnant women in Vietnam. The women were more likely to report limited system-level support for partners regarding violence and mental health, while the professionals perceived more weaknesses in policies and management of services. Traditional values tend to isolate abused women from receiving social services. The INSPIRE framework is innovative and could be applied in other contexts.
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Affiliation(s)
- Huyen Phuc Do
- School of Public Health and Social Work, Faculty of Health, Queensland University of Technology (QUT), Brisbane, QLD, Australia
- Institute of Health Economics and Technology, Hanoi, Vietnam
| | - Michael P Dunne
- Australian Centre for Health Law Research, Faculty of Business and Law, Queensland University of Technology (QUT), Brisbane, QLD, Australia
- Institute for Community Health Research, University of Medicine and Pharmacy, Hue University, Hue, Vietnam
| | - Thang Van Vo
- Institute for Community Health Research, University of Medicine and Pharmacy, Hue University, Hue, Vietnam
- Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue, Vietnam
| | - Lan Hoang Nguyen
- Institute for Community Health Research, University of Medicine and Pharmacy, Hue University, Hue, Vietnam
- Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue, Vietnam
| | - Bao-Yen Luong-Thanh
- Institute for Community Health Research, University of Medicine and Pharmacy, Hue University, Hue, Vietnam
- Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue, Vietnam
| | - Sara Valdebenito
- Institute of Criminology, University of Cambridge, Cambridge, UK
| | - Philip R A Baker
- School of Public Health and Social Work, Faculty of Health, Queensland University of Technology (QUT), Brisbane, QLD, Australia
| | - Bach Xuan Tran
- Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam
- Department of Health, Behaviours and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
| | - Tuyen Dinh Hoang
- Institute for Community Health Research, University of Medicine and Pharmacy, Hue University, Hue, Vietnam
- Faculty of Public Health, University of Medicine and Pharmacy, Hue University, Hue, Vietnam
| | - Manuel Eisner
- Institute of Criminology, University of Cambridge, Cambridge, UK
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Oladeji O, Lai J, Velazquez NR, Bammai MI, Kandel G, Spyridou A, Beer NL, Baitwabusa AE, Simmons J, Cuellar FL, Quintanilla I, Augustine J. Barriers to and facilitators of access to mental health services among pregnant adolescents and young mothers in Belize. Rev Panam Salud Publica 2025; 49:e3. [PMID: 39959761 PMCID: PMC11829315 DOI: 10.26633/rpsp.2025.3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/15/2024] [Accepted: 11/20/2024] [Indexed: 02/18/2025] Open
Abstract
Objective To identify barriers to and facilitators of access to perinatal mental health services among pregnant adolescents and young mothers in Belize. Methods This was an exploratory descriptive qualitative study using focus group discussions conducted in August 2023. The study sample was selected through purposeful sampling. Participants included pregnant adolescents, adolescent mothers and young mothers from rural and urban areas in three regions of the country (Southern, Northern, and Western). The data were analyzed using thematic analysis and the results were organized into themes. Results The barriers and facilitators identified fell into four themes. The first theme was individual factors and showed that respondents had good knowledge about mental health problems and a desire to seek mental health services. However, awareness about their availability was limited. The second theme was health systems and highlighted a lack of trust and confidence in health care providers, as well as limited access to mental health services due to insufficient human resources, long waiting times, and transportation costs. The third theme was stigma about teenage pregnancy and mental health issues. The fourth theme was social support, with both family and peer group support identified as facilitators for help-seeking among the respondents. Conclusion This study highlights important barriers to using mental health services for pregnant adolescents and young mothers in Belize. These include stigma, lack of awareness of mental health services, and limited access to them. Implementing targeted strategies to address the barriers are recommended to improve provision and uptake of mental health services among the study population.
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Affiliation(s)
| | - Joanna Lai
- UNICEFNew York, NYUnited States of AmericaUNICEF, New York, NY, United States of America.
| | - Natalia R. Velazquez
- Yale UniversityNew Haven, CTUnited States of AmericaYale University, New Haven, CT, United States of America.
| | - Mohammed I. Bammai
- Yale UniversityNew Haven, CTUnited States of AmericaYale University, New Haven, CT, United States of America.
| | - Ghanshyam Kandel
- UNICEFNew York, NYUnited States of AmericaUNICEF, New York, NY, United States of America.
| | - Andria Spyridou
- UNICEF Latin America and Caribbean Regional OfficePanama CityPanamaUNICEF Latin America and Caribbean Regional Office, Panama City, Panama.
| | - Natalia L. Beer
- Ministry of Health and WellnessBelmopanBelizeMinistry of Health and Wellness, Belmopan, Belize.
| | | | - Juliet Simmons
- Ministry of Health and WellnessBelmopanBelizeMinistry of Health and Wellness, Belmopan, Belize.
| | - Fidel L. Cuellar
- Ministry of Health and WellnessBelmopanBelizeMinistry of Health and Wellness, Belmopan, Belize.
| | - Iveth Quintanilla
- Ministry of Health and WellnessBelmopanBelizeMinistry of Health and Wellness, Belmopan, Belize.
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22
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Oladeji BD, Ayinde OO, Bello T, Kola L, Zelkowitz P, Seedat S, Gureje O. Screening and detection of perinatal depression by non-physician primary healthcare workers in Nigeria. BMC PRIMARY CARE 2025; 26:35. [PMID: 39939906 PMCID: PMC11816751 DOI: 10.1186/s12875-025-02730-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/26/2024] [Accepted: 01/28/2025] [Indexed: 02/14/2025]
Abstract
BACKGROUND Detection of perinatal depression by healthcare providers remain an important barrier to receiving treatment. This study reports on the detection of perinatal depression by frontline non-physician primary healthcare workers (PHCWs) as well as the feasibility, effectiveness and acceptability of routine screening using the 2-item patient health questionnaire (PHQ-2) during antenatal care. METHOD Twenty-seven primary healthcare facilities were assigned to screening (n = 11) and non-screening (n = 16) arms. All PHCWs in both arms were trained to diagnose and treat perinatal depression using the WHO mental health gap action intervention guide (mhGAP-IG) while those in the screening arm were trained to routinely screen with PHQ-2 first to determine need for further mhGAP-IG assessment. Perceived usefulness, feasibility and acceptability of routine screening for perinatal depression was explored in key informant interviews on a purposive sample of PHCWs (n = 20) and study participants (n = 22). RESULTS In the first 6-months following training, the detection rate of perinatal depression was 4.6% at the clinics where PHCW were not routinely screening with the PHQ-2 compared to 11% at the screening clinics. Over the next six months, with refresher training for PHCW in the screening arm and the introduction of monthly supportive supervision for PHCW in both arms, detection rates increased from 4.6 to 7.6% at non-screening clinics and from 11 to 40% at the screening clinics. Over the entire study period only 81 (15.7%) out of the 517 cases of perinatal depression were detected by the PHCWs. Detection of depression by PHCWs was associated with the severity of depression symptoms and routine screening with PHQ-2. The introduction of routine screening was acceptable to both PHCWs and perinatal women. PHCWs reported that the PHQ-2 was useful, easy to administer and feasible for routine use. CONCLUSIONS Improving detection and subsequently the treatment gap for perinatal depression require not just training of frontline healthcare workers but the introduction of additional measures such as universal screening along with supportive supervision. TRIAL REGISTRATION NUMBER The main study from which the data for this report was extracted was retrospectively registered 03 December 2019. REGISTRATION NUMBER ISRCTN 94,230,307.
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Affiliation(s)
- Bibilola D Oladeji
- Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
- WHO Collaborating Centre for Research and Training in Mental Health, Neurosciences and Drug and Alcohol Abuse, Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
| | - Olatunde O Ayinde
- Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria
| | - Toyin Bello
- WHO Collaborating Centre for Research and Training in Mental Health, Neurosciences and Drug and Alcohol Abuse, Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria
| | - Lola Kola
- WHO Collaborating Centre for Research and Training in Mental Health, Neurosciences and Drug and Alcohol Abuse, Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria
| | | | - Soraya Seedat
- Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
| | - Oye Gureje
- Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria
- WHO Collaborating Centre for Research and Training in Mental Health, Neurosciences and Drug and Alcohol Abuse, Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria
- Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
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Yevoo LL, Manzano A, Gyimah L, Kane S, Awini E, Danso-Appiah A, Agyepong IA, Mirzoev T. Conceptualizing maternal mental health in rural Ghana: a realist qualitative analysis. Health Policy Plan 2025; 40:244-258. [PMID: 39611444 PMCID: PMC11800984 DOI: 10.1093/heapol/czae116] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/01/2024] [Revised: 11/12/2024] [Accepted: 11/28/2024] [Indexed: 11/30/2024] Open
Abstract
In low- and middle-income countries, maternal mental health needs remain neglected, and common mental disorders during pregnancy and after birth are routinely associated with hormonal changes. The psycho-social and spiritual components of childbirth are often downplayed. A qualitative study was conducted as part of a wider realist evaluation on health systems responsiveness to examine the interrelationships between pregnant and postnatal women, their families, and their environment, and how these influence women's interactions with healthcare providers in Ghana. Data collection methods combined six qualitative interviews (n = 6) and 18 focus group discussions (n = 121) with pregnant and postnatal women, their relatives, and healthcare providers (midwives, community mental health nurses) at the primary healthcare level. Data analysis was based on the context-mechanism-outcome heuristic of realist evaluation methodology. A programme theory was developed and iteratively refined, drawing on Crowther's ecology of birth theory to unpack how context shapes women's interactions with public and alternative healthcare providers. We found that context interacts dynamically with embodiment, relationality, temporality, spatiality, and mystery of childbirth experiences, which in turn influence women's wellbeing in three primary areas. There is an intricate intersection of pregnancy with mental health impacting women's expectations of temporality, which does not always coincide with the timings provided by formal healthcare services. Societal deficiencies in social support structures for women facing economic challenges become particularly evident during the pregnancy and postnatal period, where women need heightened assistance. Socio-cultural beliefs associated with the mystery of childbirth, the supportive role of private providers and faith healing practices offered women a feeling of protection from uncertainty. Co-production of context-specific interventions, including the integration of maternal and mental health policies, with relevant stakeholders can help formal healthcare providers accommodate women's perspectives on spirituality and mental health, which can subsequently help to make health systems responsive to maternal mental health conditions.
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Affiliation(s)
- Linda Lucy Yevoo
- Research and Development Division, Dodowa Health Research Centre, Ghana Health Service, Dodowa-Accra, P.O. Box DD1, Ghana
| | - Ana Manzano
- School of Sociology & Social Policy, University of Leeds, Leeds, Woodhouse Lane, LS2 9JT, United Kingdom
| | - Leveana Gyimah
- Department of Psychiatry, Pantang Hospital, Accra, P.O. Box PL81, Legon-Accra, Ghana
| | - Sumit Kane
- Nossal Institute for Global Health, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia
| | - Elizabeth Awini
- Research and Development Division, Dodowa Health Research Centre, Ghana Health Service, Dodowa-Accra, P.O. Box DD1, Ghana
| | - Anthony Danso-Appiah
- Centre for Evidence Synthesis and Policy, School of Public Health, University of Ghana, Legon-Accra, P.O. Box LG 25, Ghana
| | - Irene A Agyepong
- Research and Development Division, Dodowa Health Research Centre, Ghana Health Service, Dodowa-Accra, P.O. Box DD1, Ghana
- Faculty of Public Health, Ghana College of Physicians and Surgeons, Ministries-Accra, P.O. Box MB 429, Ghana
| | - Tolib Mirzoev
- Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, Keppel Strees, WC1E 7HT, United Kingdom
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Lee B, Sheth S, Gandhi R. Impact of the Fetal Echocardiogram on Maternal Depression and Well-Being. Pediatr Cardiol 2025; 46:409-419. [PMID: 38424310 DOI: 10.1007/s00246-024-03435-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/30/2023] [Accepted: 01/27/2024] [Indexed: 03/02/2024]
Abstract
Fetal echocardiography allows for prenatal diagnosis of congenital heart disease (CHD). The objective of this study is to assess for the impact of fetal echocardiogram on levels of well-being and depression in pregnant women. Adult pregnant women carrying a fetus < 31-week gestational age were enrolled in the prospective observational study from February 2022 to June 2022. These subjects were split into two cohorts: those with CHD and those without CHD. Surveys were distributed prior to the fetal echocardiogram, six weeks later and six weeks after delivery. These surveys consisted of the Edinburgh Postpartum Depression Scale (EPDS) and questions about topics, such as anxiety and social support. Of the 152 subjects enrolled, 14 women had a fetus with CHD and 138 women had a fetus without CHD. Initial EPDS scores were elevated for the study population compared to the general population. Six weeks later, EPDS scores remained elevated. For the post-partum surveys, the EPDS scores were decreased below the rate of the general population for the group without CHD and similar to the general population rate for the CHD group. Anxiety, worry, and guilt remained low for both groups after the initial survey. Counseling from the pediatric cardiologist may help decrease anxiety and worry. Social support, like support groups, may be helpful for women carrying a fetus with CHD.
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Affiliation(s)
- Brian Lee
- Division of Pediatric Cardiology, Advocate Children's Hospital, Oak Lawn, IL, USA.
- Division of Pediatric Cardiology, Valley Children's Hospital, Madera, CA, USA.
| | - Saloni Sheth
- Division of Pediatric Cardiology, Advocate Children's Hospital, Oak Lawn, IL, USA
| | - Rupali Gandhi
- Division of Pediatric Cardiology, Advocate Children's Hospital, Oak Lawn, IL, USA
- Division of Pediatric Cardiology, University of Chicago, Chicago, IL, USA
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25
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Cribb E, Spring B, Galbally M, Gardiner F, Coleman M. Perinatal psychiatric emergencies in rural Australia: In urgent need of attention. Aust N Z J Psychiatry 2025; 59:109-114. [PMID: 39885733 DOI: 10.1177/00048674241308689] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/01/2025]
Abstract
OBJECTIVES The burden of perinatal mental illness is a significant global concern, affecting approximately 10-20% of women at this stage of life. It is well recognised that Rural Australia has far less health services and mental health specialists per capita than metropolitan regions. While women have more babies in rural settings, their access to maternal health care is conversely limited or absent. We highlight the urgent need for research, adaptation of clinical practice guidelines and service development to address the lack of specialist perinatal mental health services for women in rural Australia for emergency episodes of mental ill health in the perinatal period. While telehealth services have been utilised to bridge the gap in service provision, in this paper we articulate the need for innovative research to identify suitable and sustainable models of care in rural settings. CONCLUSION Perinatal psychiatric emergencies represent a highly interventional area of psychiatry. Across the spectrum of psychiatric disorders, few can be attributed with such specificity in anticipated time of disease onset and severity of outcome. It is imperative that we address the lack of access to speciality perinatal psychiatric care for women who reside in rural Australia.
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Affiliation(s)
- Emma Cribb
- WA Country Health Service, Perth, WA, Australia
| | - Breeanna Spring
- Molly Wardaguga Institute for First Nations Birth Rights, Faculty of Health, Charles Darwin University, Darwin, NT, Australia
- Townsville Institute of Health Research and Innovation, Townsville Hospital and Health Service, Townsville, QLD, Australia
- Centre for Women's and Children's Mental Health, Department of Psychiatry, Monash University, Clayton, VIC, Australia
| | - Megan Galbally
- Mental Health Program, Monash Health, Clayton, VIC, Australia
- Health Futures Institute, Murdoch University, Perth, WA, Australia
- School of Medicine and Psychology, The Australian National University, Canberra, ACT, Australia
| | - Fergus Gardiner
- Molly Wardaguga Institute for First Nations Birth Rights, Faculty of Health, Charles Darwin University, Darwin, NT, Australia
- The Rural Clinical School of WA, The University of Western Australia, Perth, WA, Australia
| | - Mathew Coleman
- Telethon Kids Institute, Perth, WA, Australia
- WA Country Health Service, Geraldton, WA, Australia
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26
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Eshetu T, Fekadu E, Abdella A, Mulushoa A, Medhin G, Belina M, Alem A, Keynejad R, Robbins T, Seward N, Shennan A, Howard LM, Prince M, Sandall J, Hanlon C. Towards person-centred maternal and newborn care in Ethiopia: a mixed method study of satisfaction and experiences of care. BMC Pregnancy Childbirth 2025; 25:85. [PMID: 39885399 PMCID: PMC11780771 DOI: 10.1186/s12884-024-07116-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/20/2024] [Accepted: 12/25/2024] [Indexed: 02/01/2025] Open
Abstract
BACKGROUND Person-centred maternal care is associated with positive experiences in high-income countries. Little is known about the transferability of this concept to non-Western, low-income settings. We aimed to explore women's experiences of care and investigate satisfaction with antenatal care (ANC) in relation to person-centred care and unmet psychosocial needs in rural Ethiopia. METHODS Design: facility-based, convergent mixed-method study. A cross-sectional survey included 2079 consecutive women attending ANC at eight health centres. Service satisfaction was measured using a 21-item validated measure. INDEPENDENT VARIABLES [1] person-centred care (1A: receipt of information; 1B: perceived adequacy of health worker responses) and [2] unmet psychosocial needs (2A: Patient Health Questionnaire for depressive symptoms; 2B: screening questionnaire for intimate partner violence (IPV)). Linear mixed effect regression assessed hypothesized associations between person-centred care/unmet psychosocial needs and service satisfaction, accounting for clustering at the health centre level. A linked qualitative study comprised eight in-depth interviews with women accessing ANC. Structured observations of ANC consultations rated health worker competencies (n = 65) and adherence to guidance promoting person-centred care (n = 53). Qualitative data were analysed thematically and triangulated with quantitative and observational data. RESULTS Women reported lowest satisfaction in relation to family involvement (71.5% dissatisfied) and continuity of care (65.7% dissatisfied). As hypothesised, satisfaction increased with more information received (adjusted regression coefficient (ARC) 0.96 95%CI 0.71,1.20) but reported adequacy of help from health workers did not show a dose-response relationship (test-for-trend p = 0.157). Undetected depressive symptoms (ARC - 0.21 95%CI -0.27,-0.15) and IPV (ARC - 1.52; 95%CI -2.43,-0.61) were associated with lower service satisfaction scores. Most observed consultations scored low on most indicators of person-centred care. In qualitative interviews, women valued respectful and responsive communication from health workers, which affected their willingness to disclose psychosocial problems. Triangulation of findings indicated a mismatch between what women valued about care, their reported satisfaction with care and the actual care they were observed to receive. CONCLUSIONS Systems strengthening interventions to support person-centred maternal care appear contextually relevant but need to increase women's expectations of care and agency to demand change. Prioritization of person-centred care could improve women's experience of maternal care and better address psychosocial needs.
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Affiliation(s)
- Tigist Eshetu
- Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
| | - Eshcolewyine Fekadu
- Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
| | - Ahmed Abdella
- Department of Obstetrics and Gynaecology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
| | - Adiyam Mulushoa
- Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
| | - Girmay Medhin
- Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
- Aklilu-Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
| | - Merga Belina
- Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
| | - Atalay Alem
- Department of Psychiatry, WHO Collaborating Centre for Mental Health Research and Capacity Building, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
| | - Roxanne Keynejad
- Section of Women's Mental Health, Department of Health Service and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
| | - Tanya Robbins
- Department of Women and Children's Health, School of Life and Population Sciences, King's College London, London, UK
| | - Nadine Seward
- Centre for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
| | - Andrew Shennan
- Department of Women and Children's Health, School of Life and Population Sciences, King's College London, London, UK
| | - Louise M Howard
- Section of Women's Mental Health, Department of Health Service and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
| | - Martin Prince
- King's Global Health Institute, King's College London, London, UK
| | - Jane Sandall
- Department of Women and Children's Health, School of Life and Population Sciences, King's College London, London, UK
| | - Charlotte Hanlon
- Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
- Department of Psychiatry, WHO Collaborating Centre for Mental Health Research and Capacity Building, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
- Centre for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
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Lasi S, Afshan G, Iqbal J, Ayub L. "We feel ashamed to talk about it". Navigating mental health problems for women in rural Pakistan: An interplay of financial, sociocultural, and environmental factors. Health Care Women Int 2025; 46:545-564. [PMID: 39850979 DOI: 10.1080/07399332.2025.2454579] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/22/2024] [Revised: 01/06/2025] [Accepted: 01/07/2025] [Indexed: 01/25/2025]
Abstract
The authors of this research explored community perspectives on women's mental health in rural Pakistan, using a qualitative approach to identify beliefs hindering women's access to mental healthcare. Data were collected through 15 Focus Group Discussions (FGDs) and 15 Key Informant Interviews (KIIs) with stakeholders in Gilgit-Baltistan, using purposive sampling. The researchers revealed low community awareness of mental health and a lack of diagnostic and treatment services for women. Financial, sociocultural, and environmental factors, along with gender discrimination, poverty, and violence, worsened women's mental health. The COVID-19 pandemic further escalated issues due to lockdowns, school closures, increased workload, and reduced income. The authors' results suggest that women living in rural Pakistan face a significant burden of mental health challenges, coupled with obstacles that limit their access to treatment. The authors underscored the need for both universal and targeted interventions to address mental health challenges among rural women.
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Affiliation(s)
- Seema Lasi
- Human Development Programme, Aga Khan University, Pakistan
| | - Gul Afshan
- Human Development Programme, Aga Khan University, Pakistan
| | - Javed Iqbal
- Human Development Programme, Aga Khan University, Pakistan
| | - Laiba Ayub
- Human Development Programme, Aga Khan University, Pakistan
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28
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Abajobir A, Maina D, Wambui E, Sidze EM. Association between maternal mental health and early childhood development, nutrition, and common childhood illnesses in Khwisero subcounty, Kenya. PLoS One 2025; 20:e0317762. [PMID: 39823401 PMCID: PMC11741660 DOI: 10.1371/journal.pone.0317762] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/14/2024] [Accepted: 01/04/2025] [Indexed: 01/19/2025] Open
Abstract
BACKGROUND Despite the significant public health burden of maternal mental health disorders in sub-Saharan Africa (SSA), limited data are available on their effects on early childhood development (ECD), nutritional status, and child health in the region. AIMS This study investigated the association between maternal mental health and ECD, nutritional status, and common childhood illnesses, while controlling for biological, social, financial, and health-related factors and/or confounders. METHOD As part of the Innovative Partnership for Universal and Sustainable Healthcare (i-PUSH) program evaluation study, initiated in November 2019, a cohort of low-income rural families, including pregnant women or women of childbearing age with children under five, was recruited for this study. A total of 24 villages were randomly selected from a list of villages near two health facilities. Following a census to identify eligible households, 10 households per village were randomly selected. Data collection included maternal mental health, assessed using Centre for Epidemiological Studies Depression (CES-D) scale, ECD, nutritional status (anthropometric measurements), and common childhood illnesses, their symptoms, and healthcare utilization. This study presents a cross-sectional analysis of the data drawn from endline survey of 299 target mothers and 315 children. RESULTS The majority of the mothers were aged between 25 and 34 years. The mean age of children was 3.2 years, with 53% being male. The overall maternal mental health score, as measured by the CES-D scale, was 28. Children of mothers with higher CES-D scores exhibited poorer ECD domains, lower nutritional status indicators, and increased incidence of ill-health in the previous two weeks, in both unadjusted and adjusted analyses. Individual, parental, and household factors-including maternal age, household wealth index, and decision-making regarding child healthcare-were significantly associated with children's development, nutrition status, and health outcomes. CONCLUSION Children of mothers with low mental health scores demonstrated suboptimal developmental outcomes, nutritional status, and overall well-being, particularly for those from impoverished households. These findings suggest that improving the socioeconomic conditions of low-income households is essential for promoting children's development, nutritional status, and well-being. Longitudinal studies are needed to further investigate the impact of maternal mental health on child development, nutrition, and health outcomes, considering additional factors across the maternal, newborn, and child health continuum. TRIAL REGISTRATION FOR THE PARENT AND NESTED STUDY ClinicalTrials.gov (NCT04068571), AEA Registry (AEARCTR-0006089) and PACTR (PACTR202204635504887).
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Affiliation(s)
| | - Daniel Maina
- African Population and Health Research Center, Nairobi, Kenya
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Namatovu HK, Magumba MA, Akena D. E-Screening for Prenatal Depression in Kampala, Uganda Using the Edinburgh Postnatal Depression Scale: Survey Results. Online J Public Health Inform 2025; 17:e51602. [PMID: 39810415 PMCID: PMC11750128 DOI: 10.2196/51602] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/11/2023] [Revised: 08/23/2024] [Accepted: 10/14/2024] [Indexed: 01/16/2025] Open
Abstract
Background Perinatal depression remains a substantial public health challenge, often overlooked or incorrectly diagnosed in numerous low-income nations. Objective The goal of this study was to establish statistical baselines for the prevalence of perinatal depression in Kampala and understand its relationship with key demographic variables. Methods We employed an Android-based implementation of the Edinburgh Postnatal Depression Scale (EPDS) to survey 12,913 women recruited from 7 government health facilities located in Kampala, Uganda. We used the standard EPDS cutoff, which classifies women with total scores above 13 as possibly depressed and those below 13 as not depressed. The χ2 test of independence was used to determine the most influential categorical variables. We further analyzed the most influential categorical variable using odds ratios. For continuous variables such as age and the weeks of gestation, we performed a simple correlation analysis. Results We found that 21.5% (2783/12,913, 95% CI 20.8%-22.3%) were possibly depressed. Respondents' relationship category was found to be the most influential variable (χ21=806.9, P<.001; Cramer's V=0.25), indicating a small effect size. Among quantitative variables, we found a weak negative correlation between respondents' age and the total EPDS score (r=-0.11, P<.001). Similarly, a weak negative correlation was also observed between the total EPDS score and the number of previous children of the respondent (r=-0.07, P<.001). Moreover, a weak positive correlation was noted between weeks of gestation and the total EPDS score (r=0.02, P=.05). Conclusions This study shows that demographic factors such as spousal employment category, age, and relationship status have an influence on the respondents' EPDS scores. These variables may serve as proxies for latent factors such as financial stability and emotional support.
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Affiliation(s)
- Hasifah Kasujja Namatovu
- Department of Information Systems, College of Computing and Information Sciences, Makerere University Kampala, Makerere University, P.O Box 7062, Kampala, Uganda, 256 774049030
| | - Mark Abraham Magumba
- Department of Information Systems, College of Computing and Information Sciences, Makerere University Kampala, Makerere University, P.O Box 7062, Kampala, Uganda, 256 774049030
| | - Dickens Akena
- Department of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda
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Kokkinaki T, Anagnostatou N, Markodimitraki M, Roumeliotaki T, Tzatzarakis M, Vakonaki E, Giannakakis G, Tsatsakis A, Hatzidaki E. The development of preterm infants from low socio-economic status families: The combined effects of melatonin, autonomic nervous system maturation and psychosocial factors (ProMote): A study protocol. PLoS One 2025; 20:e0316520. [PMID: 39792923 PMCID: PMC11723634 DOI: 10.1371/journal.pone.0316520] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/08/2024] [Accepted: 12/11/2024] [Indexed: 01/12/2025] Open
Abstract
Preterm births constitute a major public health issue and a chronic, cross-generational condition globally. Psychological and biological factors interact in a way that women from low socio-economic status (SES) are disproportionally affected by preterm delivery and at increased risk for the development of perinatal mental health problems. Low SES constitutes one of the most evident contributors to poor neurodevelopment of preterm infants. Maternal perinatal mental health disorders have persistent effects on behavioral and physiological functioning throughout the lifespan and may even be evident across generations. The overall objective of the proposed longitudinal, multi-disciplinary and multi-method study is to compare the association of psychosocial (maternal mental health, intersubjectivity, attachment, family functioning, dyadic coping and perceived social support), and biological factors (melatonin and heart rate variability) with preterm infants' development at 9 months (corrected age), between low and high SES families. We will collect data from preterm neonates (<37 weeks gestational age) hospitalized in the Department of Neonatology/Neonatal Intensive Care Unit of the University General Hospital of Heraklion, Greece, and their mothers. Data collection of psychosocial and biological factors will be carried out at birth, and at the corrected age of 6 and 9 months, while preterm infants' cognitive and social development will be assessed at 9 months corrected age. The findings of this study may highlight the need for early interventions for new mothers coming from low SES in order to promote their preterm infants' optimal early neurodevelopment and for community-evidence-based prevention efforts to restrict the cycle of health inequities and intergenerational mental disorders.
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Affiliation(s)
- Theano Kokkinaki
- Child Development and Education Unit, Laboratory of Applied Psychology, Department of Psychology, University of Crete, Rethymnon, Crete, Greece
| | - Nicole Anagnostatou
- Department of Neonatology/Neonatal Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Crete, Greece
| | - Maria Markodimitraki
- Department of Preschool Education, University of Crete, Rethymnon, Crete, Greece
| | - Theano Roumeliotaki
- Department of Social Medicine, School of Medicine, University of Crete, Heraklion, Crete, Greece
| | - Manolis Tzatzarakis
- Laboratory of Toxicology, School of Medicine, University of Crete, Heraklion, Crete, Greece
| | - Elena Vakonaki
- Laboratory of Toxicology, School of Medicine, University of Crete, Heraklion, Crete, Greece
| | - Giorgos Giannakakis
- Institute of Computer Science, Foundation for Research and Technology Hellas, Heraklion, Crete, Greece
- Department of Electronic Engineering, Hellenic Mediterranean University, Chania, Crete, Greece
| | - Aristidis Tsatsakis
- Laboratory of Toxicology, School of Medicine, University of Crete, Heraklion, Crete, Greece
| | - Eleftheria Hatzidaki
- Department of Neonatology/Neonatal Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Crete, Greece
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Adhikari S, Rana H, Joshi MP, Cheng S, Castillo T, Huang KY. Parental wellbeing, parenting, and child mental health in families with young children in Arghakhanchi, Nepal. BMC Pediatr 2025; 25:6. [PMID: 39762775 PMCID: PMC11702219 DOI: 10.1186/s12887-024-05358-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/12/2023] [Accepted: 12/23/2024] [Indexed: 01/11/2025] Open
Abstract
BACKGROUND Children's social-emotional development and mental well-being are critical to adult mental health. However, little is known about the mechanisms or factors that contribute to poor child mental health in low- and middle-income countries. Given the lack of child mental health research to guide interventions or social-emotional learning programs and policy planning, the present study aimed to address these knowledge gaps by examining the psychopathology mechanism involved in the development of childhood mental health problems. METHODS This cross-sectional study recruited parents (N = 393) whose children attended preschool to primary classes in the Arghakhanchi district of Nepal. Data were gathered through parent interviews. Structural Equation Modeling was used to examine the pathways of the mediational mechanism that examined the influence of parental well-being on parenting and children's mental health outcomes. RESULTS Approximately 22% of the parents were at risk for moderate to severe mental health problems (anxiety: 24%, depression:19%). Parental mental health problems were higher in families who reported food insecurity, among female parents, less educated parents, and those who perceived themselves on a lower social ladder. Parental mental health, social support, and perceived class were associated with parent-child conflict. Greater parent-child conflict was associated with decreased social competence and increased anger, anxiety, and depression in children. CONCLUSION The results partially support the mediational model that Nepali parents' well-being (especially in mental health symptoms, social support, and perception of family's social class domains) is associated with less optimal parenting and, in turn, greater child mental health problems and lower social competence. This study provides new evidence of cross-cultural consistency in child psychopathology and guides the development of evidence-based programs to prevent and promote mental health among Nepali children and families.
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Affiliation(s)
- Sirjana Adhikari
- CWIN-Nepal, Ravi Bhawan, Kathmandu, Nepal.
- Adolescent Mental Health Unit, Mental Hospital, Lagankhel, Nepal.
| | - Hari Rana
- HealthRight International, Jwagal, Lalitpur, Nepal
| | | | - Sabrina Cheng
- Department of Population Health, New York University Grossman School of Medicine, New York, USA
| | | | - Keng-Yen Huang
- Department of Population Health, New York University Grossman School of Medicine, New York, USA
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Aziz HA, Yahya HDB, Ang WW, Lau Y. Global prevalence of depression, anxiety, and stress symptoms in different trimesters of pregnancy: A meta-analysis and meta-regression. J Psychiatr Res 2025; 181:528-546. [PMID: 39700731 DOI: 10.1016/j.jpsychires.2024.11.070] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/04/2023] [Revised: 07/02/2024] [Accepted: 11/27/2024] [Indexed: 12/21/2024]
Abstract
The global prevalence of psychological problems in different trimesters is unclear due to methodological constraints in previous reviews. A precise estimate would be a key first step in raising awareness and allocating resources. This review aims to (1) calculate the global prevalence of depression, anxiety, and stress symptoms during different trimesters and (2) determine the factors influencing their prevalence estimates. A comprehensive search across eight databases was conducted. The meta packages in R software were used to perform meta-analysis, subgroup analysis, and meta-regression analysis. The Newcastle Ottawa Scale was used to assess the study quality, while the Grading of Recommendations, Assessment, Development, and Evaluation method was utilized to assess the certainty of the evidence. A total of 88 studies with 61,719 participants across 48 countries were included. The prevalences of depression, anxiety, and stress symptoms during all trimesters were 27% (95% CI: 23-31), 37% (95% CI: 31-42), and 26% (95% CI: 9-49), respectively. The second trimester had the highest prevalence of depression (30%) and anxiety (28%) symptoms, whereas the third trimester had the highest prevalence of stress symptoms (52%). A series of subgroup and meta-regression analyses revealed that regions, economic levels of the country, setting, the COVID-19 pandemic, and quality of study were significant factors. Most studies were high quality, but the certainty of the evidence was very low. Findings can contribute as evidence to raising awareness about specific psychological problems during different trimesters. Implementing effective policies and launching targeted interventions can help minimize the prevalence.
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Affiliation(s)
- Halimatusaadiyah Abdul Aziz
- Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
| | - Huda Dianah Binte Yahya
- Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
| | - Wen Wei Ang
- Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
| | - Ying Lau
- The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
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Islas-Preciado D, Estrada-Camarena E, Galea LAM. Menstrually-related mood disorders and postpartum depression: Convergent aspects in aetiology. Front Neuroendocrinol 2025; 76:101171. [PMID: 39638001 DOI: 10.1016/j.yfrne.2024.101171] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/27/2024] [Revised: 11/13/2024] [Accepted: 12/02/2024] [Indexed: 12/07/2024]
Abstract
Females diagnosed with Menstrually-related mood disorders (MRMDs) have more risk to develop postpartum depression (PPD). There are overlapping symptoms between MRMDs and PPD such as anxiety, depressed mood, irritability, that can contribute to a lower quality of life. MRMDs and PPD share components in their etiology such as dramatic hormonal oscillations, and alterations in Hypothalamus-Pituitary-Adrenal (HPA) axis activity that may impair GABAergic neurotransmission. As well, stressful events that impact HPA regulation may play an important role in the etiology of MRMDs and PPD. Here we review common hormone fluctuations across the menstrual cycle and pregnancy/postpartum to identify shared pathways that could contribute to greater sensitivity in people with MRMDs and PPD. This review summarizes hormone sensitivity, HPA axis activity and neurosteroids effects on GABAergic transmission and the potential role of chronic stress in developing MRMDs and PPD. In addition, other potential etiopathological factors, such as serotonin and the immune system, are discussed. Investigating the etiopathology of MRMDs and PDD will help to better understand the complexity of factors involved in these disorders that affect females across the reproductive years.
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Affiliation(s)
- D Islas-Preciado
- Laboratorio de Neuropsicofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñíz", Ciudad de México, México; Centre for Brain Health, University of British Columbia, Vancouver, Canada; Laboratorio de Neuromodulación, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñíz", Ciudad de México, México.
| | - E Estrada-Camarena
- Laboratorio de Neuropsicofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñíz", Ciudad de México, México
| | - L A M Galea
- Centre for Brain Health, University of British Columbia, Vancouver, Canada; Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, ON, Canada.
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Kansagra DJ, Amin CD, Chauhan RB. The Prevalence and Risk Factors of Postpartum Depression in Western India: A Cross-Sectional Study. Indian J Community Med 2025; 50:70-75. [PMID: 40124799 PMCID: PMC11927844 DOI: 10.4103/ijcm.ijcm_232_23] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/13/2023] [Accepted: 04/21/2024] [Indexed: 03/25/2025] Open
Abstract
Background Postpartum depression (PPD) is a nonpsychotic mental health condition associated with child birth. It poses a major global public health challenge as it remains unrecognized most of the time and impairs both the immediate and long-term health of both the mother and child. The study was conducted to estimate the prevalence and associated risk factors for PPD. Materials and Methods A cross-sectional study was conducted among 450 women who delivered babies within the past 1-12 months and attending a tertiary care hospital during April to November 2021. Systemic random sampling was used to obtain the desired sample size. Basic sociodemographic variables (age, duration of postpartum period, residence, religion, education, occupation, birth spacing, complication during pregnancy, desired gender of child, birth weight of baby) related to pregnancy were collected. The Edinburgh Postnatal Depression Scale was used to estimate the prevalence of PPD. Results The prevalence of PPD in the study was 14.2%. The mean ± standard deviation age of women was 27.1 ± 4.7 years. Sociodemographic factors such as maternal age, low level of education, and family type and obstetric factors such as age at first pregnancy, parity, and history of abortion were significantly associated with PPD (P < 0.05). Conclusion Risk factors related to sociodemographic and obstetric history were found to be significantly associated with PPD. To prevent major depression in postpartum, early detection and timely referral are needed.
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Affiliation(s)
- Dharti J. Kansagra
- Community Medicine Department, P D U Govt. Medical College, Rajkot, Gujarat, India
| | - Chikitsa D. Amin
- Community Medicine Department, P D U Govt. Medical College, Rajkot, Gujarat, India
| | - Rajendra B. Chauhan
- Community Medicine Department, P D U Govt. Medical College, Rajkot, Gujarat, India
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Rodríguez-Reynaldo M, Rivera-Orraca Z, Ramos Monserrate G, Martínez-González K. Mental health impact of the COVID-19 pandemic in perinatal women living in Puerto Rico. J Reprod Infant Psychol 2025; 43:181-194. [PMID: 37427837 PMCID: PMC10776800 DOI: 10.1080/02646838.2023.2232388] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/21/2022] [Accepted: 06/26/2023] [Indexed: 07/11/2023]
Abstract
BACKGROUND Studies have reported an increase in mental health disorders during the perinatal period as a result of the COVID-19 pandemic and the quarantine restrictions imposed. The effects of untreated maternal mental health have an adverse impact on the mother, the development of the baby, and the family system. Determinants of health, recent natural disasters, and disparities in perinatal care that impact perinatal women in Puerto Rico place them at a higher risk of mental health difficulties. AIM It is therefore, of extreme importance, to evaluate the effect that the COVID-19 pandemic has had on this vulnerable population. DESIGN This is a cross-sectional observational study that interviewed 100 women in the perinatal period during the COVID-19 lockdown measures in Puerto Rico. Participants completed the Spanish version of the COVID-19 Perinatal Experiences (COPE-IS) questionnaire and assessments of clinical depression (PHQ-9) and anxiety (GAD-7). RESULTS The prevalence of moderate to severe risk of depression in this sample is 14%, while 17% showed clinical signs of anxiety. Concerns about social impact and the quarantine mandate were the most common stressors reported. Additionally, our sample reported concerns about the impact the pandemic would have on future employment and finances. CONCLUSION Perinatal women showed significantly higher prevalence of depression and anxiety during the COVID -19 pandemic when compared to the mental health prevalence of the general population pre-pandemic in Puerto Rico. The concerns identified during the pandemic provide information on the importance of a biopsychosocial approach to perinatal mental health care.
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Affiliation(s)
- Marianela Rodríguez-Reynaldo
- Department of Obstetrics and Gynecology, University of Puerto Rico- Conceptualization, Investigation, Methodology, Resources, Writing - Original Draft, Writing - Review & Editing, San Juan, Puerto Rico
| | - Zilkia Rivera-Orraca
- Department of Psychiatry, University of Puerto Rico- Investigation, Methodology, Analysis, Resources, Review & Editing, San Juan, Puerto Rico
| | - Gian Ramos Monserrate
- Department of Psychiatry, University of Puerto Rico- Investigation, Methodology, Analysis, Resources, Review & Editing, San Juan, Puerto Rico
| | - Karen Martínez-González
- Department of Psychiatry, University of Puerto Rico- Investigation, Methodology, Analysis, Resources, Review & Editing, San Juan, Puerto Rico
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Hossain SJ, Tofail F, Rahman A, Fisher J, Hamadani JD, Rahman SM. Parenting with nutrition education and unconditional cash reduce maternal depressive symptoms and improve quality of life: findings from a cluster randomised controlled trial in urban Bangladesh. Glob Health Action 2024; 17:2426784. [PMID: 39560615 PMCID: PMC11578405 DOI: 10.1080/16549716.2024.2426784] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/28/2024] [Accepted: 11/04/2024] [Indexed: 11/20/2024] Open
Abstract
BACKGROUND Maternal post-natal depression is a global public health problem. Parenting interventions targeting children's development may also bring benefits to mothers, but few parenting interventions have been studied thoroughly. OBJECTIVES The study aimed to measure the effect of a parenting intervention using culturally appropriate and locally made toys, along with nutrition education and unconditional cash, on maternal depressive symptoms (MDS) and quality of life (QoL). METHODS The study was a cluster randomised controlled trial with two arms: i) intervention: parenting with nutrition education and unconditional cash and ii) comparison: unconditional cash in an urban setting in Bangladesh. Twenty clusters were randomised to either the intervention or control group. Community Health Workers (CHWs) delivered parenting and nutrition education sessions fortnightly in households for one year. The participants were mother-child (6-16 months) dyads. The MDS and QoL were measured using the Self-Reporting Questionnaire-20 and a brief version of the QoL questionnaire. Linear regression analysis was used to assess the treatment effects. RESULTS After one year of intervention, 547 mothers (93%) completed the study. The mothers in the intervention group had lower MDS [Regression coefficient (β)=-1.53, Confidence interval (95% CI)=-2.28, -0.80] and higher QoL scores in physical health [β = 4.21 (95% CI = 1.71, 6.73)], psychological health [β = 3.14 (95% CI = 1.10, 5.19)], social relationships [β = 3.21 (95% CI = 0.76, 5.66)] and environment [β = 3.40 (95% CI = 1.37, 5.44)] compared with the comparison group. CONCLUSION Parenting interventions including nutrition education and unconditional cash, aimed at improving children's development, resulted in a reduction in maternal depressive symptoms and improvement in quality of life.
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Affiliation(s)
- Sheikh Jamal Hossain
- Global Health and Migration Unit, Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
- Maternal and Child Health Division (MCHD), International Centre for Diarrhoeal Disease Research Bangladesh (icddr, b), Mohakhali, Dhaka, Bangladesh
| | - Fahmida Tofail
- Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Mohakhali, Dhaka, Bangladesh
| | - Anisur Rahman
- Maternal and Child Health Division (MCHD), International Centre for Diarrhoeal Disease Research Bangladesh (icddr, b), Mohakhali, Dhaka, Bangladesh
| | - Jane Fisher
- Global and Women’s Health, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia
| | - Jena Derakhshani Hamadani
- Maternal and Child Health Division (MCHD), International Centre for Diarrhoeal Disease Research Bangladesh (icddr, b), Mohakhali, Dhaka, Bangladesh
| | - Syed Moshfiqur Rahman
- Global Health and Migration Unit, Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
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Djatche Miafo J, Nzebou D, Stoll B, Yimga Ngambia JC, Kouo Ngamby Ekedy M, von Overbeck Ottino S, Moayedoddin A. Validation of the Edinburgh postnatal depression scale and prevalence of depression among adolescent mothers in a Cameroonian context. Sci Rep 2024; 14:30670. [PMID: 39730398 DOI: 10.1038/s41598-024-79370-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/26/2024] [Accepted: 11/08/2024] [Indexed: 12/29/2024] Open
Abstract
The Edinburgh Postnatal Depression Scale (EPDS) is the screening tool for perinatal depression, and its cut-off score varies according to context and population. In Cameroon, no study has yet defined a cut-off score or the prevalence of perinatal depression in adolescent mothers. Our aim is to determine the cut-off for teenage mothers in Cameroon. The study is cross-sectional and analytical in nature. The EPDS was used to screen for symptoms of depression and an interview based on the DSM-5 criteria for depression was conducted to diagnose the depressive syndrome. The data were processed with Epidata 3.1 and was analysed with SPSS 25. Positive and negative predictive values (PPV, NVP) were calculated. The optimal EPDS score was determined by taking into account the importance of false-negative and false-positive test results. 1633 adolescent mothers were recruited. The prevalence of perinatal depression was 60.8% (95% CI = 58.5, 63.2). The cut-off score for this population was ≥ 11. Sensitivity was 92.6% (95% CI = 0.913, 0.939) specificity 53.2% (95% CI = 0.508, 0.556), PPV 75.5% and NPV 80.2%. This score of ≥ 11 is retained because false-negative results have important adverse consequences. This study on the validation of the EPDS and the prevalence of perinatal depression in a population of teenage mothers is new in Cameroon and central Africa.
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Affiliation(s)
| | - Daniel Nzebou
- Uni-Psy Et Bien-Être (UNIPSY), Centre, Yaoundé, 99322, Cameroon
| | - Beat Stoll
- Actions en Santé Publique, 1204, Geneva, Switzerland
- Institut de Santé Globale de L'Université de Genève, 1205, Geneva, Switzerland
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Tadesse A, Helton JJ, Kong V. Intimate Partner Violence and Level of Household Food Scarcity in Mozambique. JOURNAL OF INTERPERSONAL VIOLENCE 2024:8862605241307633. [PMID: 39727153 DOI: 10.1177/08862605241307633] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/28/2024]
Abstract
Although food insecurity in its various forms is consistently associated with the presence of intimate partner violence (IPV), it is still unknown if various levels of severity of hunger predict IPV when important extraneous mental health, interpersonal, and social support indicators are considered. The study applied a posttest-only comparison group quasi-experimental design. The samples were randomly drawn from married women (n = 202) in Mozambique. The logistic regression model showed a significant association between multiple forms of IPV and multiple forms of food scarcity; women experiencing severe hunger were consistently between 3.5- and 5-times greater odds of reporting IPV compared to those without hunger, even when controlling for important covariates.
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Alao MA, Ibrahim OR, Yekinni SA, Sotimehin SA, Diala UM, Briggs DC, Musa AZ, Imam ZO, Famutimi EO, Idris AA, Ayuk AC, Iloh KK, Odimegwu CL, Adeyemi AT, Medupin PF, Adeniyi YC, Nnamani KO, Tongo OO. Breastfeeding support as predictors of sustainable breastfeeding practices of nursing mothers with common mental disorders in tertiary hospital nurseries in Nigeria: a cross sectional study. BMC Pregnancy Childbirth 2024; 24:834. [PMID: 39707225 PMCID: PMC11660493 DOI: 10.1186/s12884-024-07031-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/08/2023] [Accepted: 12/02/2024] [Indexed: 12/23/2024] Open
Abstract
BACKGROUND The postpartum period is associated with an increased risk of maternal mental disorders. The combined effect of having the mother's infant admitted to a tertiary hospital in a low-resource setting and the need to exclusively breastfeed the infant may exaggerate this risk. This study aimed to determine the breastfeeding support provided to mothers whose infants were hospitalised in Nigerian tertiary hospital nurseries and the prevalence of common mental health disorders among this population. METHODS This was a national cross-sectional study involving mothers of hospitalised infants from eleven Nigerian tertiary hospitals between May and August 2022. To assess mothers' mental health and breastfeeding support, we utilised the WHO self-reporting Questionnaire 20 and an adapted WHO/UNICEF ten-step breastfeeding support package. RESULTS Of the 1,120 mothers recruited from neonatal nurseries in the six geopolitical zones in Nigeria, only 895 had a complete dataset for analysis. The mean age of the mothers was 29.9 ± 6.2; with 54.7% belonging to the low-socioeconomic class. Most of the mothers (835, 93.3%) received antenatal care, and 591: 66.0% were delivered at term. Overall, less than half (427; 47.7%) of the mother received optimal breastfeeding support. One in every four, 216; 24.0% of nursing mothers (95% CI: 21.235 to 26.937%) had common mental disorders (CMD). Pre-pregnant mental health disorders were reported in 41; 4.6% of the nursing mothers. Overall, the lowest performing areas of breastfeeding support were family-centred care (198, 22.1%), practical skill demonstration in the ward (n = 279, 31.2%), and antenatal clinics (n = 294, 32.8%). CMDs were significantly associated with the healthcare provider's practical breastfeeding skill demonstration and the provision of storage facilities for breastmilk and family-centered-care. Across Nigeria's six geopolitical zones, there was an inverse relationship between optimal breastfeeding support and the proportion of mothers with CMDs. The northern zone provided better breastfeeding support and had fewer CMDs than the southern region of the country. CONCLUSION Common mental disorders are prevalent among nursing mothers in Nigerian tertiary hospital nurseries, and they are inversely related to breastfeeding support. Urgently required in tertiary hospitals for improved and sustainable breastfeeding practices are a focus on family-centred care and enhanced health workers' practical breastfeeding support skills.
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Affiliation(s)
- Michael Abel Alao
- Department of Pediatrics, College of Medicine University of Ibadan & University College Hospital, Ibadan, Ibadan, Oyo State, Nigeria.
| | - Olayinka Rasheed Ibrahim
- Department of Pediatrics, University of Ilorin Teaching Hospital, Kwara State, Ilorin, Nigeria
- Department of Paediatrics, Federal Medical Centre, Kastina State, Kastina, Nigeria
| | | | - Sikirat Adetoun Sotimehin
- Paediatrics Department, Faculty of Clinical Sciences, College of Health Sciences, Nile University of Nigeria, Abuja, Nigeria
| | - Udochukwu Michael Diala
- Department of Paediatrics, Faculty of Clinical Sciences, College of Health Sciences, University of Jos, Jos, Plateau State, Nigeria
| | - Datonye Christopher Briggs
- Department of Paediatrics, Faculty of Clinical Sciences, College of medical Sciences, Rivers State University & Rivers State University Teaching Hospital, Port Harcourt, Rivers State, Nigeria
| | - Aishatu Zaidu Musa
- Department of Paediatrics, Abubakar Tafewa Balewa University, Bauchi, Bauchi State, Nigeria
| | | | | | - Adedeji Abiodun Idris
- Department of Paediatrics, Abubakar Tafewa Balewa University, Bauchi, Bauchi State, Nigeria
| | - Adaeze C Ayuk
- Department of Paediatrics, College of Medicine, University of Nigeria & University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria
| | - Kenechukwu Kosisochukwu Iloh
- Department of Paediatrics, College of Medicine, University of Nigeria & University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria
| | - Chioma Laura Odimegwu
- Department of Paediatrics, College of Medicine, University of Nigeria & University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria
| | - Ayomide Toluwanimi Adeyemi
- Department of Paediatrics, College of Medicine, University College Hospital Ibadan Centre for African Newborn Health and Nutrition, University College Hospital, Ibadan, Oyo State, Nigeria
| | - Patricia F Medupin
- Department of Paediatrics Federal Teaching Hospital, Lokoja, Kogi State, Nigeria
| | - Yetunde C Adeniyi
- Department of Psychiatry, College of Medicine & Department of Child and Adolescent Psychiatry, University of Ibadan & University College Hospital, Ibadan, Oyo State, Nigeria
| | - Kenechi Ogbodo Nnamani
- Department of Paediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria
| | - Olukemi Oluwatoyin Tongo
- Department of Pediatrics, College of Medicine University of Ibadan & University College Hospital, Ibadan, Ibadan, Oyo State, Nigeria
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Peng Y, Wu Y, Huang Y, Zhou N, Fang W, Xi J. Unidimensional or multidimensional? Revisiting the psychometrics of PHQ-9 and EPDS using bifactor model and item response theory in 2939 Chinese perinatal women. J Affect Disord 2024; 367:686-695. [PMID: 39218318 DOI: 10.1016/j.jad.2024.07.148] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/28/2023] [Revised: 06/17/2024] [Accepted: 07/03/2024] [Indexed: 09/04/2024]
Abstract
BACKGROUND Perinatal depression often goes undetected and untreated in low- and middle-income countries like China. Reliable screening tools can improve this situation. The Patient Health Questionnaire-9 (PHQ-9) and the Edinburgh Postnatal Depression Scale (EPDS), two widely used tools, often exhibit inconsistent factor structures, leading to debates regarding their unidimensionality versus multidimensionality and casting doubts on their psychometric properties. METHODS Our study aimed to assess the utility of PHQ-9 and EPDS in Chinese perinatal women and to address the debate by employing the bifactor model and item response theory (IRT). We enrolled 2939 perinatal women from a maternity and infant health hospital serving all 16 districts of Shanghai. The bifactor model was used to examine the factor structure of PHQ-9 and EPDS, while IRT analysis evaluated the psychometric properties. RESULTS The indices derived from the bifactor model indicated that both PHQ-9 and EPDS should be used as unidimensional measurements. All items in PHQ-9 and EPDS showed adequate discriminative ability and difficulty, but certain items require further refinement. PHQ-9 demonstrated better measurement precision at high levels of latent depression than EPDS. LIMITATIONS These findings might not generalize to perinatal women in impoverished areas. The absence of clinical diagnoses limited the exploration of sensitivity and specificity. CONCLUSIONS PHQ-9 and EPDS are effective tools for detecting depression in Chinese perinatal women and should be used as unidimensional tools. Our study expands upon existing psychometric findings related to PHQ-9 and EPDS, offering valuable insights for their application in research and clinical settings.
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Affiliation(s)
- Yanan Peng
- Shanghai Key Laboratory of Mental Health and Psychological Crisis Intervention, Affiliated Maternity and Infant Health Hospital (ECNU), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
| | - Yuancheng Wu
- Shanghai Key Laboratory of Mental Health and Psychological Crisis Intervention, Affiliated Maternity and Infant Health Hospital (ECNU), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
| | - Ying Huang
- Shanghai Changning Maternity and Infant Health Hospital, Affiliated Maternity and Infant Health Hospital, East China Normal University, Shanghai, China.
| | - Ningning Zhou
- Shanghai Key Laboratory of Mental Health and Psychological Crisis Intervention, Affiliated Maternity and Infant Health Hospital (ECNU), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
| | - Wenli Fang
- Shanghai Changning Maternity and Infant Health Hospital, Affiliated Maternity and Infant Health Hospital, East China Normal University, Shanghai, China.
| | - Juzhe Xi
- Shanghai Key Laboratory of Mental Health and Psychological Crisis Intervention, Affiliated Maternity and Infant Health Hospital (ECNU), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China; Positive Education China Academy (PECA) of Han-Jing Institute for Studies in Classics, Juzhe Xi's Master Workroom of Shanghai School Mental Health Service, China Research Institute of Care and Education of Infants and Young Children, East China Normal University, Shanghai, China.
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Asefa A, Hanlon C, Marchal B, Homer C, Gebremedhin S, Tunçalp Ö, Sarkar N, Delamou A, McNab S, Beňová L. Revisiting health systems to integrate perinatal mental health into maternal and child health services: perspectives from research, policy and implementation. BMJ Glob Health 2024; 9:e015820. [PMID: 39663124 PMCID: PMC11784375 DOI: 10.1136/bmjgh-2024-015820] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/02/2024] [Accepted: 11/15/2024] [Indexed: 12/13/2024] Open
Affiliation(s)
- Anteneh Asefa
- Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium
| | - Charlotte Hanlon
- Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK
- Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
- Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
| | - Bruno Marchal
- Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium
| | - Caroline Homer
- Maternal, Child and Adolescent Health Program, Burnet Institute, Melbourne, Victoria, Australia
| | | | - Özge Tunçalp
- UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland
| | - Nandini Sarkar
- Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium
| | - Alexandre Delamou
- Centre National de Formation et de Recherche en Santé Rurale, Maférinyah, Forécariah, Guinea
- Africa Center of Excellence (CEA-PCMT), Gamal Abdel Nasser University of Conakry, Conakry, Guinea
| | - Shanon McNab
- MOMENTUM Country and Global Leadership, Jhpiego, Baltimore, Maryland, USA
| | - Lenka Beňová
- Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium
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Wong EF, Saini AK, Accortt EE, Wong MS, Moore JH, Bright TJ. Evaluating Bias-Mitigated Predictive Models of Perinatal Mood and Anxiety Disorders. JAMA Netw Open 2024; 7:e2438152. [PMID: 39625723 PMCID: PMC11615713 DOI: 10.1001/jamanetworkopen.2024.38152] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/29/2024] [Accepted: 08/15/2024] [Indexed: 12/06/2024] Open
Abstract
Importance Machine learning for augmented screening of perinatal mood and anxiety disorders (PMADs) requires thorough consideration of clinical biases embedded in electronic health records (EHRs) and rigorous evaluations of model performance. Objective To mitigate bias in predictive models of PMADs trained on commonly available EHRs. Design, Setting, and Participants This diagnostic study collected data as part of a quality improvement initiative from 2020 to 2023 at Cedars-Sinai Medical Center in Los Angeles, California. The study inclusion criteria were birthing patients aged 14 to 59 years with live birth records and admission to the postpartum unit or the maternal-fetal care unit after delivery. Exposure Patient-reported race and ethnicity (7 levels) obtained through EHRs. Main Outcomes and Measures Logistic regression, random forest, and extreme gradient boosting models were trained to predict 2 binary outcomes: moderate to high-risk (positive) screen assessed using the 9-item Patient Health Questionnaire (PHQ-9), and the Edinburgh Postnatal Depression Scale (EPDS). Each model was fitted with or without reweighing data during preprocessing and evaluated through repeated K-fold cross validation. In every iteration, each model was evaluated on its area under the receiver operating curve (AUROC) and on 2 fairness metrics: demographic parity (DP), and difference in false negatives between races and ethnicities (relative to non-Hispanic White patients). Results Among 19 430 patients in this study, 1402 (7%) identified as African American or Black, 2371 (12%) as Asian American and Pacific Islander; 1842 (10%) as Hispanic White, 10 942 (56.3%) as non-Hispanic White, 606 (3%) as multiple races, 2146 (11%) as other (not further specified), and 121 (<1%) did not provide this information. The mean (SD) age was 34.1 (4.9) years, and all patients identified as female. Racial and ethnic minority patients were significantly more likely than non-Hispanic White patients to screen positive on both the PHQ-9 (odds ratio, 1.47 [95% CI, 1.23-1.77]) and the EPDS (odds ratio, 1.38 [95% CI, 1.20-1.57]). Mean AUROCs ranged from 0.610 to 0.635 without reweighing (baseline), and from 0.602 to 0.622 with reweighing. Baseline models predicted significantly greater prevalence of postpartum depression for patients who were not non-Hispanic White relative to those who were (mean DP, 0.238 [95% CI, 0.231-0.244]; P < .001) and displayed significantly lower false-negative rates (mean difference, -0.184 [95% CI, -0.195 to -0.174]; P < .001). Reweighing significantly reduced differences in DP (mean DP with reweighing, 0.022 [95% CI, 0.017-0.026]; P < .001) and false-negative rates (mean difference with reweighing, 0.018 [95% CI, 0.008-0.028]; P < .001) between racial and ethnic groups. Conclusions and Relevance In this diagnostic study of predictive models of postpartum depression, clinical prediction models trained to predict psychometric screening results from commonly available EHRs achieved modest performance and were less likely to widen existing health disparities in PMAD diagnosis and potentially treatment. These findings suggest that is critical for researchers and physicians to consider their model design (eg, desired target and predictor variables) and evaluate model bias to minimize health disparities.
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Affiliation(s)
- Emily F. Wong
- Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, California
| | - Anil K. Saini
- Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, California
| | - Eynav E. Accortt
- Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California
| | - Melissa S. Wong
- Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California
| | - Jason H. Moore
- Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, California
| | - Tiffani J. Bright
- Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, California
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Hasan M, Al Amin M. Determinants of depression among ever-married adolescent girls in Bangladesh: Evidence from the Bangladesh Adolescent Health and Wellbeing Survey 2019-2020. PLoS One 2024; 19:e0314283. [PMID: 39585812 PMCID: PMC11588215 DOI: 10.1371/journal.pone.0314283] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/02/2024] [Accepted: 11/07/2024] [Indexed: 11/27/2024] Open
Abstract
BACKGROUND Common mental health disorders in early life represent a major challenge and these conditions become more complicated and substantial during the development period of adolescence. Despite the global concern over the increasing prevalence of mental health issues among adolescents, it remains largely a neglected area of research and health policy in Bangladesh, where the burden of child marriage is significantly higher. This study aimed to investigate the prevalence and factors associated with depression among married adolescent girls in Bangladesh. METHODS The study utilized the data from first-ever Bangladesh Adolescent Health and Wellbeing Survey (BAHWS), conducted in 2019-2020. A total of 1,693 married adolescent girls were included in the final analysis. Depressive symptoms were measured using the standardized Patient Health Questionnaire-9 (PHQ-9) tool. Descriptive statistics were applied to assess the prevalence of depression, while bivariate analysis was done to measure the significance of the variables. Furthermore, logistic regression was used to examine the association between any form of depression and selected covariates. RESULTS The overall prevalence of mild to severe levels of depression among the participants was 53.1% (Mild: 40.3%; Moderate: 9.9%; Moderately severe: 2.3%; Severe: 0.6%). In the multivariable logistic regression model, it was found that adolescents from richest wealth quintile were 35% less likely to suffer from depression (AOR = 0.65; 95% CI = 0.45-0.92; P value = 0.02). Additionally, physical violence (AOR = 1.55; 95% CI = 1.14-2.09; P value = 0.004), sexual harassment (AOR = 1.50; 95% CI = 1.11-2.01; P value = 0.007), social bullying (AOR = 2.25; 95% CI = 1.73-2.91; P value < .001), and cyberbullying (AOR = 1.75; 95% CI = 1.10-2.77; P value = 0.01) were associated with depression. CONCLUSIONS This study demonstrated that more than half of the married adolescents suffer from mild to severe levels of depression, while any form of violence and harassment significantly increases their risk of depression. Therefore, a more inclusive policy is needed, engaging with communities and local stakeholders, to lay out key actions and intervention pathways to address the issue of violence against married adolescent girls as the extent and spectrum of violence continue to evolve.
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Affiliation(s)
- Mehedi Hasan
- Research Monitoring and Evaluation Division, Room to Read, Dhaka, Bangladesh
| | - Md Al Amin
- Health Systems and Population Studies Division, International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh
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Rtbey G, Andualem F, Nakie G, Takelle GM, Mihertabe M, Fentahun S, Melkam M, Tadesse G, Birhan B, Tinsae T. Perinatal depression and associated factors in Ethiopia: a systematic review and meta-analysis. BMC Psychiatry 2024; 24:822. [PMID: 39563272 PMCID: PMC11577585 DOI: 10.1186/s12888-024-06246-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/23/2023] [Accepted: 11/04/2024] [Indexed: 11/21/2024] Open
Abstract
BACKGROUND Perinatal depression is a significant public health issue affecting one in four women globally. It occurs at a critical time of a woman's life; affecting her relationships with family, and child's emotional, behavioral, and cognitive development. Considering the burden of the problem to the whole family, this systematic review and meta-analysis was conducted to estimate the pooled prevalence of perinatal depression and its determinants in Ethiopia to provide up-to-date evidence at a national level. METHODS All observational studies conducted on perinatal depression in Ethiopia were included based on the selection criteria. Data was extracted using Microsoft Excel and then exported to STATA version-11 for analysis. The random-effects model was employed to estimate the pooled effect size of perinatal depression and its determinants with 95% confidence intervals. Funnel plots analysis and Egger regression tests were conducted to check the publication bias. Sub-group and sensitivity analyses were also performed. RESULTS This systematic review and meta-analysis included thirty studies and the pooled prevalence of perinatal depression in Ethiopia was 24.29% (95% CI (21.98, 26.59)). According to the subgroup analysis, the pooled prevalence of antenatal depression and others (postnatal and perinatal depression) was 24.24% and 24.52% respectively. Regarding determinants of perinatal depression, having unplanned pregnancy [OR = 3.04 (2.2, 4.2)], intimate partner violence [OR = 3.09(2.14, 4.46)], poor social support [OR = 3.3(2.38, 4.57)], and a history of depression [OR = 3.68(2.45, 5.52)] were significantly associated with depression. CONCLUSION AND RECOMMENDATION This study showed that the pooled prevalence of perinatal depression in Ethiopia was found to be high. To ensure the mental health of both the mother and child, health professionals should routinely screen perinatal women for depression giving special focus for those with a history of depression and managing them accordingly.
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Affiliation(s)
- Gidey Rtbey
- Department of Psychiatry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
| | - Fantahun Andualem
- Department of Psychiatry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
| | - Girum Nakie
- Department of Psychiatry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
| | - Girmaw Medfu Takelle
- Department of Psychiatry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
| | - Milen Mihertabe
- Department of Psychiatry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
| | - Setegn Fentahun
- Department of Psychiatry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
| | - Mamaru Melkam
- Department of Psychiatry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
| | - Gebresilassie Tadesse
- Department of Psychiatry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
| | - Belete Birhan
- School of Nursing, College of Health Science and Medicine , Wolaita Sodo University, Sodo, Ethiopia
| | - Techilo Tinsae
- Department of Psychiatry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
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Desrosiers A, Saran I, Albanese AM, Antonaccio CM, Neville SE, Esliker R, Jambai M, Feika M, Betancourt TS. Task-sharing to promote caregiver mental health, positive parenting practices, and violence prevention in vulnerable families in Sierra Leone: a pilot feasibility study. BMC Psychiatry 2024; 24:787. [PMID: 39529061 PMCID: PMC11555851 DOI: 10.1186/s12888-024-06209-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/17/2024] [Accepted: 10/22/2024] [Indexed: 11/16/2024] Open
Abstract
BACKGROUND The prevalence of household violence in low- and middle-income countries (LMICs) is high, and exposure to violence has significant adverse effects on both mental health and child development across generations. Evidence-based services to improve parenting practices and reduce household violence in LMICs are scarce, particularly across rural regions of West Africa. This study explored the feasibility, acceptability, and potential benefits of an evidence-based home-visiting intervention to promote early childhood development and reduce household violence-the Family Strengthening Intervention for Early Childhood Development and Violence-Prevention (FSI-ECD + VP)-among vulnerable families in rural regions of Sierra Leone. METHODS Eighty dual-caregiver households in the Makeni region of Sierra Leone were included in the study (N = 160 caregivers; 73% female). Eligibility criteria included having at least one child aged 6-36 months and elevated scores (> 62.5) on the Difficulties in Emotion Regulation Scale (DERS). Community Health Workers (CHWs) employed in the Makeni region completed a 3-week FSI-ECD + VP training. Families were randomized to receive either the FSI-ECD + VP or treatment as usual (TAU). Research assistants blinded to treatment assignment assessed caregiver mental health, caregiver-child interactions, and household violence at baseline, post-intervention, and 3-month follow-up time points. RESULTS Triangulation of quantitative and qualitative data showed that caregivers, CHWs, and supervisors generally perceived the intervention as beneficial, feasible, and acceptable. Mixed effects models showed that caregivers who received the FSI-ECD + VP had significantly improved caregiver-child relationship outcomes compared to TAU as assessed by the Home Observation for Measurement of the Environment and the Observation of Caregiver-Child Interactions at post-intervention. Preliminary data also suggests that caregivers receiving the FSI-ECD + VP were less likely to have experienced intimate partner physical violence during the post-intervention period, and had lower symptoms of anxiety and depression at 3-month follow-up. CONCLUSIONS FSI-ECD + VP delivery by CHWs in Sierra Leone may be feasible and acceptable; it may also help improve caregiver-child interactions and reduce the likelihood of household violence among vulnerable families with young children. Task-sharing approaches may help increase acceptability and access to evidence-based behavioral interventions that promote early childhood development and violence prevention among families in rural regions of Sierra Leone and other similar settings. TRIAL REGISTRATION The study is registered in clinicaltrials.gov (NCT03045640; 07/22/2020). This study follows the Consort 2010 guidelines for reporting of clinical trials.
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Affiliation(s)
- Alethea Desrosiers
- Department of Psychiatry and Human Behavior, Brown University, Warren Alport Medical School, 345 Blackstone Blvd, Providence, RI, 02906, USA.
| | - Indrani Saran
- Boston College School of Social Work, 140 Commonwealth Avenue, Chestnut Hill, MA, 02496, USA
| | - Ariana M Albanese
- Department of Psychiatry and Human Behavior, Brown University, Warren Alport Medical School, 345 Blackstone Blvd, Providence, RI, 02906, USA
| | - Cara M Antonaccio
- Department of Psychiatry and Human Behavior, Brown University, Warren Alport Medical School, 345 Blackstone Blvd, Providence, RI, 02906, USA
| | - Sarah E Neville
- Department of Psychiatry and Human Behavior, Brown University, Warren Alport Medical School, 345 Blackstone Blvd, Providence, RI, 02906, USA
| | - Rebecca Esliker
- University of Makeni, VWQV+54G, Lunsar-Makeni Highway, Makeni, Sierra Leone
| | - Musu Jambai
- Caritas-Freetown, Savage Road, Freetown, Sierra Leone
| | - Mahmoud Feika
- Caritas-Freetown, Savage Road, Freetown, Sierra Leone
| | - Theresa S Betancourt
- Boston College School of Social Work, 140 Commonwealth Avenue, Chestnut Hill, MA, 02496, USA
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Khadka N, Fassett MJ, Oyelese Y, Mensah NA, Chiu VY, Yeh M, Peltier MR, Getahun D. Trends in Postpartum Depression by Race, Ethnicity, and Prepregnancy Body Mass Index. JAMA Netw Open 2024; 7:e2446486. [PMID: 39565621 PMCID: PMC11579791 DOI: 10.1001/jamanetworkopen.2024.46486] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/11/2024] [Accepted: 09/30/2024] [Indexed: 11/21/2024] Open
Abstract
Importance Postpartum depression (PPD) poses significant risks to maternal and child health. Understanding temporal trends is crucial for evaluating prevalence and identifying populations at risk. Objective To evaluate recent trends in PPD and assess how these trends are associated with race, ethnicity, and prepregnancy body mass index (BMI). Design, Setting, and Participants A serial, cross-sectional analysis using data from the Kaiser Permanente Southern California (KPSC) electronic health records (EHRs), with live and stillbirths at 20 or more weeks of gestation who were KPSC members at the time of delivery between 2010 and 2021. Data were analyzed from July 2022 to August 2023. Exposures Self-reported race, ethnicity, and recorded prepregnancy BMI. Main outcome measures PPD cases were identified using validated diagnostic codes and prescription records within 12 months postpartum in the KPSC EHRs. Patients with an Edinburgh Postnatal Depression Scale score of 10 or more within 6 months postpartum were further evaluated by a mental health specialist for formal PPD diagnosis. Results In this study of 442 308 pregnancies, the median (IQR) maternal age at delivery was 31 (27-34) years. The cohort was racially and ethnically diverse, with 62 860 individuals (14.2%) identifying as Asian/Pacific Islander, 231 837 (52.4%) as Hispanic, 33 207 (7.5%) as non-Hispanic Black, 108 201 (24.5%) as non-Hispanic White, 5903 (1.3%) as multiple or other, and 300 (0.1%) unknown. PPD prevalence doubled over the study period, increasing from 9.4% in 2010 to 19.0% in 2021. The largest increases were observed among Asian and Pacific Islander participants (280% increase) and non-Hispanic Black participants (140% increase). PPD rates increased across all BMI categories, particularly among individuals with obesity (class I) and morbid obesity (class II/III). Conclusions and Relevance In this cross-sectional study, PPD diagnosis increased significantly across all racial and ethnic groups and BMI categories over the past decade. While rising PPD may reflect improved screening and diagnosis practices, the persistently high rates highlight the need to develop and implement interventions to prevent the condition while expanding efforts to mitigate the impact of PPD on maternal and child health.
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Affiliation(s)
- Nehaa Khadka
- Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena
| | | | - Yinka Oyelese
- Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts
| | - Nana A. Mensah
- Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena
- Now with Brigham Young University, Provo, Utah
| | - Vicki Y. Chiu
- Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena
| | - Meiyu Yeh
- Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena
| | - Morgan R. Peltier
- Department of Psychiatry and Behavioral Health, Jersey Shore University Medical Center, Neptune, New Jersey
- Department of Psychiatry and Behavioral Health, Hackensack-Meridian School of Medicine, Nutley, New Jersey
| | - Darios Getahun
- Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena
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Malik A, Waqas A, Atif N, Perin J, Zaidi A, Sharif M, Rahman A, Surkan PJ. Multiple mediation analysis of a task-shared psychosocial intervention for perinatal anxiety: Exploratory findings from a randomized controlled trial in Pakistan. J Affect Disord 2024; 364:41-47. [PMID: 39137833 PMCID: PMC11905935 DOI: 10.1016/j.jad.2024.08.021] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/29/2023] [Revised: 07/16/2024] [Accepted: 08/09/2024] [Indexed: 08/15/2024]
Abstract
BACKGROUND The "Healthy Mother Healthy Baby" (HMHB) study is a phase three, single-blind randomized clinical trial conducted at Holy Family Hospital (HFH) in association with Rawalpindi Medical University (RMU). We aimed to examine the mediators of a specialized psychosocial approach based on Cognitive Behavioural Therapy principles, targeting pregnant women experiencing anxiety. The HMHB intervention was effective in treating perinatal anxiety symptoms and preventing future depressive episodes. METHODS The trial randomized participants into two arms: the HMHB intervention or Enhanced Usual Care (EUC), following World Health Organization guidelines. The HMHB intervention comprised strategies to strengthen social support networks, improving mother-baby bonding and strategies to deal with interpersonal conflicts, economic challenges, and societal gender preferences using cognitive and behavioural techniques and culturally resonant illustrations. Participants underwent rigorous data collection at three pivotal timepoints: baseline, third trimester, and 6-weeks postnatal. The primary outcome was anxiety symptom severity scores using the Hospital Anxiety and Depression Scale (HADS) at 6-weeks post-childbirth. Four potential mediators - social support, behavioural activation, perceived stress, and pregnancy experience - were assessed in the third trimester of pregnancy. RESULTS A total of 1200 participants were randomized to the HMHB and EUC arms. In the six-week follow-up time point, 379 participants remained in the EUC group, and 387 continued in the HMHB group. Post-intervention, HMHB participants displayed significant improvements in postnatal anxiety and depression scores. Mediation analyses revealed social support and pregnancy hassles as significant mediators of the intervention's effect on postnatal anxiety outcomes, while only social support emerged as a significant mediator for depression outcomes. CONCLUSION The HMHB intervention showed promising results in improving anxiety and depression scores among pregnant women. Significant mediation effects suggest the importance of targeting social support and managing pregnancy-related hassles for optimal intervention effectiveness.
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Affiliation(s)
- A Malik
- Department of Public Mental Health, Health Services Academy, Islamabad, Pakistan
| | - A Waqas
- Department of Primary Care and Mental Health, Institute of Population Health, University of Liverpool, Liverpool, United Kingdom.
| | - N Atif
- Human Development Research Foundation, Rawalpindi, Pakistan
| | - J Perin
- Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
| | - A Zaidi
- Human Development Research Foundation, Rawalpindi, Pakistan
| | - M Sharif
- Human Development Research Foundation, Rawalpindi, Pakistan
| | - A Rahman
- Department of Primary Care and Mental Health, Institute of Population Health, University of Liverpool, Liverpool, United Kingdom
| | - P J Surkan
- Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
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Kumari P, Basu S. Postpartum Depression and Its Determinants: A Cross-Sectional Study. Cureus 2024; 16:e74044. [PMID: 39712834 PMCID: PMC11659481 DOI: 10.7759/cureus.74044] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 11/19/2024] [Indexed: 12/24/2024] Open
Abstract
Background Postpartum depression (PPD) is the most prevalent psychological disorder after childbirth associated with a negative impact on the daily functioning of mothers and the cognitive development of infants. Inequitable primary mental health access in lower-middle-income countries (LMICs) further aggravates this major public health problem. Objective The objective of this study is to estimate the prevalence and determinants of PPD among women reporting to secondary care facilities in Delhi, India. Methods A cross-sectional study was conducted in the outpatient settings of two secondary care (one government and one private) hospitals in the Delhi-National Capital Region among mothers of infants aged below six months. The study was conducted from January to June 2023. Data were collected by a single trained investigator using a self-designed interview schedule, while PPD was measured by administering the Edinburgh Postnatal Depression Scale (EPDS). Data were analyzed with Stata statistical software, version 15.1 (StataCorp LLC, College Station, TX). P < 0.05 was considered statistically significant. Results The mean age of the study participants was 28.49 ± 3.77 years with 53 (18.28%) detected as having possible postpartum depression on screening with the EPDS. On adjustment for covariates, the participants with husbands consuming alcohol (adjusted odds ratio, 6.97; 95% confidence interval {CI}, 2.73-17.8), those who underwent C-section (adjusted odds ratio, 4.39; 95% CI, 1.02-18.85), and those giving birth in private hospitals (adjusted odds ratio, 5.48; 95% CI, 1.53-19.55) had significantly higher odds of having PPD. In contrast, mothers staying at home (not employed) (adjusted odds ratio, 0.08; 95% CI, 0.02-0.41), without specific preference for the newborn's gender (adjusted odds ratio, 0.07; 95% CI, 0.01-0.78), and those living in nuclear families (adjusted odds ratio, 0.03; 95% CI, 0.005-0.19) had significantly lower odds of PPD. Conclusion Nearly one in five mothers were screened for having possible PPD. Prioritizing birth preparedness during the antenatal period and strengthening health system screening protocols may prevent and mitigate the effects of PPD.
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Affiliation(s)
- Puja Kumari
- Epidemiology and Public Health, Indian Institute of Public Health-Delhi, Delhi, IND
| | - Saurav Basu
- Community Medicine, Employees' State Insurance Corporation (ESIC) Medical College and Hospital, Kolkata, IND
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Waqas A, Sikander S, Malik A, Atif N, Rahman A. Optimizing psychotherapies for perinatal depressive symptom dimensions by strengthening social support networks: an exploratory mediation analysis approach. Glob Ment Health (Camb) 2024; 11:e91. [PMID: 39464560 PMCID: PMC11504941 DOI: 10.1017/gmh.2024.116] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/21/2024] [Revised: 08/29/2024] [Accepted: 09/16/2024] [Indexed: 10/29/2024] Open
Abstract
The Thinking Healthy Program (THP) is a multicomponent low-intensity cognitive behavioral therapy-based psychosocial intervention. This intervention has been shown to be clinically effective in perinatal depression (PND) and feasible for implementation in low-resourced settings. It has also been shown to work universally for different phenotypes of PND. However, the mechanism through which THP resolves different phenotypes of PND are unclear. The present investigation presents secondary mediation analyses of a dataset curated from a cluster randomized controlled trial conducted in Pakistan assessing the effectiveness of the THP. Women aged 16-45 years in their third pregnancy trimester, with a diagnosis of PND, underwent 16 sessions of the intervention. The severity of depression was assessed using the Hamilton Depression Rating Scale (HDRS). 2-1-1 mediation models revealed that social support exerted significant mediation in driving the intervention effects for improving the severity of depressive symptoms on the HDRS [B (SE) = 0.45 (0.09), 95% CI: 0.30-0.60] and its symptom dimensions of core emotional symptoms [B (SE) = 0.27 (0.06), 95% CI: 0.18-0.37], somatic symptoms [B (SE) = 0.24 (0.04), 95% CI: 0.16-0.31] and insomnia symptoms [B (SE) = 0.04 (0.02), 95% CI: 0.02-0.07].
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Affiliation(s)
- Ahmed Waqas
- Department of Primary Care and Mental Health, Institute of Population Health, University of Liverpool, Liverpool, UK
| | - Siham Sikander
- Department of Primary Care and Mental Health, Institute of Population Health, University of Liverpool, Liverpool, UK
| | - Abid Malik
- Human Development Research Foundation, Islamabad, Pakistan
- Department of Public Mental Health, Health Services Academy, Islamabad, Pakistan
| | - Najia Atif
- Human Development Research Foundation, Islamabad, Pakistan
| | - Atif Rahman
- Department of Primary Care and Mental Health, Institute of Population Health, University of Liverpool, Liverpool, UK
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Sergi MR, Saggino A, Balsamo M, Picconi L, Anchora L, Tommasi M. Risk factors of the antenatal depression in a sample of Italian pregnant women: a preliminary study. BMC Pregnancy Childbirth 2024; 24:689. [PMID: 39433991 PMCID: PMC11494958 DOI: 10.1186/s12884-024-06704-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/06/2023] [Accepted: 07/16/2024] [Indexed: 10/23/2024] Open
Abstract
BACKGROUND Antenatal depression is characterized by low mood, insomnia, disorganised behaviour, irritability, and agitation during the pregnancy. If underestimated, antenatal depression is untreated during the pregnancy. It is associated to higher levels of suicide, higher risk of depression after childbirth, preeclampsia, preterm birth, low birth weight, poor interactions between child and mother and severe obstetric outcomes. New data underlined the importance to prevent the risk of depression during the pregnancy. This study examines the predictive validity of potential risk factors, such as socio-demographic and psychological factors, in developing the antenatal depression. METHODS The sample was composed by Italian pregnant women (N = 247, mean age of 33.77, SD = 4.78 years). This sample completed the Edinburg Postnatal Depression Scale (EPDS), the Teate Depression Inventory (TDI) and questionnaires about demographic variables. To study associations among variables examined bivariate correlations were computed. To analyse the role of socio-demographic factors and the psychological dimension to predict the severity of the antenatal depression a logistic regression was performed. RESULTS Results showed significantly positive correlations between the EPDS and the TDI, and no associations among the EPDS and all socio-demographic factors. Therefore, only the psychological factors were significant predictive risk factors of antenatal period. Finally, higher score of the depression measured via TDI predicted higher score of the EPDS. CONCLUSIONS Our results had implications in clinical field. Indeed, the early diagnosis of depression during the pregnancy can help operators in the gynaecological field to prevent the depression in the post-partum period.
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Affiliation(s)
- Maria Rita Sergi
- Department of Psychology, University of Chieti-Pescara, Chieti, Italy.
| | - Aristide Saggino
- Department of Psychology, University of Chieti-Pescara, Chieti, Italy
| | - Michela Balsamo
- Department of Psychology, University of Chieti-Pescara, Chieti, Italy
| | - Laura Picconi
- Department of Psychology, University of Chieti-Pescara, Chieti, Italy
| | | | - Marco Tommasi
- Department of Psychology, University of Chieti-Pescara, Chieti, Italy
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