©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Current approach to disseminated intravascular coagulation related to sepsis - organ failure type
Jose J Zaragoza, Missael V Espinoza-Villafuerte, Intensive Care Unit, Hospital Español, Mexico City 11520, Mexico
Author contributions: Zaragoza JJ and Espinoza-Villafuerte MV contributed equally to the work, participating in collection of the data and writing the manuscript and approving the final version of it.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Correspondence to: Jose J Zaragoza, MD, Intensive Care Unit, Hospital Español, Ejercito Nacional 613 Piso 9, Granada, Mexico City 11520, Mexico. zaragozagalvan@hotmail.com
Telephone: +52-55-52559600
Received: August 29, 2016
Peer-review started: September 1, 2016
First decision: October 26, 2016
Revised: November 18, 2016
Accepted: December 16, 2016
Article in press: December 19, 2016
Published online: February 6, 2017
Processing time: 142 Days and 23.6 Hours
Peer-review started: September 1, 2016
First decision: October 26, 2016
Revised: November 18, 2016
Accepted: December 16, 2016
Article in press: December 19, 2016
Published online: February 6, 2017
Processing time: 142 Days and 23.6 Hours
Core Tip
Core tip: Disseminated intravascular coagulation (DIC) is a syndrome characterized by the systemic activation of blood clotting, which generates large amount of intravascular thrombin and fibrin. In the context of severe sepsis and septic shock, DIC is related to increased severity, greater number and seriousness of organ failures, more frequent side-effects from treatment itself, and worse outcomes. We ought to review the most important and updated information available in the literature about DIC in severe sepsis and septic shock.