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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hematol. Jan 21, 2026; 12(1): 115355
Published online Jan 21, 2026. doi: 10.5315/wjh.v12.i1.115355
Published online Jan 21, 2026. doi: 10.5315/wjh.v12.i1.115355
Nomogram-based prediction of post-splenectomy thrombocytosis in children with hereditary spherocytosis
Tao Zhang, Zhong-Ce Li, Zhu-Bin Pan, Shi-Qin Qi, Ran Tang, Department of Pediatric Surgery, Anhui Provincial Children’s Hospital, Hefei 231000, Anhui Province, China
Co-first authors: Tao Zhang and Zhong-Ce Li.
Author contributions: Zhang T and Li ZC contributed equally to data acquisition and analysis as co-first authors; Pan ZB and Qi SQ assisted with data interpretation and literature review; Tang R conceptualized the study, supervised the analysis, and critically revised the manuscript. All authors reviewed and approved the final version.
Supported by Anhui Provincial Health and Wellness Scientific Research Project, No. AHWJ2024Aa30300.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Anhui Provincial Children’s Hospital (approval No. EYLL-2024-005). All procedures were conducted in accordance with the ethical standards of the institutional and national research committees and with the 1964 Helsinki Declaration and its later amendments.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request. De-identified clinical data supporting the findings of this study will be made available six months after publication and can be accessed by contacting the corresponding author via email (njmutr@163.com).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ran Tang, MD, Department of Pediatric Surgery, Anhui Provincial Children’s Hospital, No. 39 Wangjiang East Road, Baohe District, Hefei 231000, Anhui Pro
Received: October 16, 2025
Revised: October 24, 2025
Accepted: December 29, 2025
Published online: January 21, 2026
Processing time: 96 Days and 18.9 Hours
Revised: October 24, 2025
Accepted: December 29, 2025
Published online: January 21, 2026
Processing time: 96 Days and 18.9 Hours
Core Tip
Core Tip: Postoperative thrombocytosis is a frequent complication following splenectomy in children with hereditary spherocytosis, yet its predictors remain unclear. In this large cohort of 230 patients, we identified elevated reticulocyte count, low preoperative platelet count, and higher transfusion volume as independent risk factors. Based on these parameters, we developed and validated a nomogram with excellent discriminative power, good calibration, and strong clinical utility. This practical tool enables early risk stratification and individualized perioperative management, potentially reducing thrombotic complications and improving outcomes in pediatric hereditary spherocytosis patients undergoing splenectomy.