©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Primary cutaneous B cell lymphoma: Clinical features, diagnosis and treatment
Fergun Yilmaz, Nur Soyer, Filiz Vural, Department of Hematology, Ege University, 35100 Izmir, Turkey
Author contributions: Yilmaz F, Soyer N and Vural F contributed to this paper.
Conflict-of-interest: The authors declare no conflict of interest.
Correspondence to: Filiz Vural, MD, Department of Hematology, Ege University Hospital, Bornova, 35100 Izmir, Turkey. fivural@yahoo.com
Telephone: +90-23-23904541
Received: October 2, 2014
Peer-review started: October 3, 2014
First decision: November 27, 2014
Revised: December 18, 2014
Accepted: January 9, 2015
Article in press: Janurary 12, 2015
Published online: February 2, 2015
Processing time: 110 Days and 3.3 Hours
Peer-review started: October 3, 2014
First decision: November 27, 2014
Revised: December 18, 2014
Accepted: January 9, 2015
Article in press: Janurary 12, 2015
Published online: February 2, 2015
Processing time: 110 Days and 3.3 Hours
Core Tip
Core tip: Primary cutaneous B cell lymphoma is a type of lymphoma that presents in the skin without evidence of extra-cutaneous involvement. Prognosis and treatment being different from systemic lymphomas involving the skin makes differential diagnosis very important. It is a heterogeneous group of diseases that consists of indolent (primary cutaneous marginal zone lymphoma, primary cutaneous follicle centre lymphoma) and aggressive forms (primary cutaneous diffuse large B cell lymphoma, leg type and intravascular large B cell lymphoma). The indolent forms are mostly confined to the skin and have good prognosis whereas aggressive forms present with disseminated disease and are treated mostly with systemic combination chemotherapies.