Effectiveness of oral vs intravenous acetaminophen on pain management following total joint arthroplasty: A systematic review and meta-analysis

Table 1 Description of included studies

Studies	Cases	Mean age (year)	Female gender (%)	Type	Anesthesia	Surgical approach	Intervention group	Control group	Follow-up
Barrington et al[15], 2019	56475/134216	66/67	61.4/63.3	Retrospective study	Unclear	TKA	1000 mg of intravenous acetaminophen	1000 mg of oral acetaminophen	Unclear
O'Neal et al[8], 2017	57/58	68/67	44/55	RCT	Spinal anesthesia	TKA	1000 mg of intravenous acetaminophen	1000 mg of oral acetaminophen	1 month
Suarez et al[11], 2018	52/52	66.6/67.3	28/26	RCT	Spinal anesthesia	TKA	4000 mg of intravenous acetaminophen	4000 mg of oral acetaminophen	6 weeks
Hickman et al[10], 2018	245/241	67/67	57.1/61.4	RCT	General or spinal anesthesia	TKA	1000 mg of intravenous acetaminophen	2500 mg of oral acetaminophen	8 weeks
Yu et al[12], 2020	318/527	66/65	70/73	Retrospective study	Spinal anesthesia	TKA	1000 mg of intravenous acetaminophen	1000 mg of oral acetaminophen	Unclear
Politi et al[13], 2017	63/57	66/69	45/40	RCT	General anesthesia	THA and TKA	1000 mg of intravenous acetaminophen	1000 mg of oral acetaminophen	2 months
Westrich et al[14], 2019	77/77	63/65	64/55	RCT	Spinal anesthesia	THA	1000 mg of intravenous acetaminophen	1000 mg of oral acetaminophen	Unclear

RCT: Randomized controlled trial; TKA: Total knee arthroplasty; THA: Total hip arthroplasty.

Table 2 The Methodological Index for Non-Randomized Studies scale

Quality assessment for non-RCT	Barrington	Yu
A clearly stated aim	2	2
Inclusion of consecutive patients	2	2
Prospective of data collection	2	2
Endpoints appropriate to the aim of the study	2	2
Unbiased assessment of the study endpoint	1	1
A follow-up period appropriate to the aims of study	1	1
Less than 5% loss to follow-up	0	0
Prospective calculation of the sample size	2	2
An adequate control group	2	2
Contemporary groups	2	2
Baseline equivalence of groups	2	2
Adequate statistical analyses	2	2
Total score	20	20

RCT: Randomized controlled trial.