Long-term assessment of collagenase treatment for Dupuytren’s contracture: A 10-year follow-up study

Table 1 Inclusion and exclusion criteria of the prospective study

Inclusion criteria	Exclusion criteria
DC with a PED of at least 20° at MCPJ and any degree at PIPJ	Breastfeeding or pregnant (or planning to be) during the treatment phase
No oral anticoagulant therapy; patient in therapy with anti-platelet drugs (discontinued for at least 7 d before treatment)	Undergoing any treatment of the affected hand up to 90 d prior to commencement of the trial
Positive table-top test (a patient fails to lay the palm of the hand and the fingers flat on a table surface)	Known systemic hypersensitivity to collagenase or any of the other components of the product
TPED ≥ 45° (that is greater than or equal to the second stage according to the Tubiana-Michon classification)	Presence of other psychiatric or organic conditions that could jeopardize the patient’s compliance
Palpable cord
Informed consent from the patient
Consent for examination according to the plan

DC: Dupuytren’s contracture; PED: Passive extension deficit; MCPJ: Metacarpophalangeal joint; PIPJ: Proximal interphalangeal joint; TPED: Total passive extension deficit.

Table 2 Results for patients injected at the metacarpophalangeal joint

Patient	MCPJ PED in degrees				MCPJ TPED in degrees				10-yr recurrence
	Before	12 wk	7 yr	10 yr	Before	12 wk	7 yr	10 yr
1	60	0	0	5	70	10	10	25	Yes
2	75	0	5	5	75	10	10	25	Yes
3	50	0	5	5	50	5	10	15	No
4	45	0	0	0	60	10	10	20	No
5	45	0	5	5	55	10	10	15	No
6	90	0	5	30	100	10	10	40	Yes
7	50	0	5	5	50	5	10	15	No
8	50	0	5	5	50	5	10	15	No
9	45	0	5	10	95	10	10	20	No
10	70	0	5	35	75	10	10	40	Yes
11	70	0	0	0	70	10	10	10	No
12	45	5	5	5	50	5	10	15	No
13	45	5	5	10	45	10	10	20	No
14	50	5	5	5	50	10	15	40	Yes
15	50	0	5	5	50	5	5	15	No
16	45	5	10	10	45	10	10	20	No
17	45	0	5	5	45	5	10	25	Yes
18	70	5	0	0	80	10	10	30	Yes
19	50	0	5	25	50	10	15	40	Yes
20	45	0	5	25	45	10	10	40	Yes
21	80	0	5	5	95	10	10	30	Yes
22	45	5	5	25	45	10	20	50	Yes
23	50	0	0	0	45	10	10	30	Yes
24	45	5	5	5	45	15	10	15	No
25	45	0	5	5	45	5	10	35	Yes
26	45	0	5	25	45	10	10	40	Yes
27	65	5	10	30	65	10	25	30	Yes
28	45	5	15	30	45	10	10	30	Yes
29	50	0	0	0	50	5	10	10	No
30	45	5	5	5	55	10	10	15	No
31	45	0	15	30	55	10	10	30	Yes
mean ± SD	60	0	0	5	70	10	10	25	N/A
	75	0	5	5	75	10	10	25	N/A

MCPJ: Metacarpophalangeal joint; PED: Passive extension deficit; TPED: Total passive extension deficit; N/A: Not applicable; SD: Standard deviation.

Table 3 Results for patients injected at the proximal interphalangeal joint

Patient	PIPJ PED in degrees				PIPJ TPED in degrees				10-yr recurrence
	Before	12 wk	7 yr	10 yr	Before	12 wk	7 yr	10 yr
32	50	10	30	40	50	10	15	50	Yes
33	65	10	20	40	70	10	15	50	Yes
34	70	20	25	50	70	20	25	60	Yes
35	65	10	20	40	65	10	20	50	Yes
36	60	15	20	45	70	10	15	70	Yes
37	90	15	20	35	95	15	15	60	Yes
mean ± SD	66.7	13.3	22.5	41.7	70.0	12.5	17.5	56.7	N/A
	13.3	4.1	4.2	5.2	14.5	4.2	4.2	8.2	N/A

PIPJ: Proximal interphalangeal joint; PED: Passive extension deficit; TPED: Total passive extension deficit; N/A: Not applicable; SD: Standard deviation.