Published online Jan 18, 2026. doi: 10.5312/wjo.v17.i1.108554
Revised: July 16, 2025
Accepted: November 10, 2025
Published online: January 18, 2026
Processing time: 267 Days and 19.4 Hours
Complex trimalleolar ankle fractures are a major orthopaedic challenge, with an incidence of 4.22 per 10000 person-years in the United States and an annual cost of 3.4 billion dollars. This review synthesizes current evidence on diagnostic pro
Core Tip: The management of trimalleolar ankle fractures is often complex, with high incidence rates and substantial economic impact. Advanced imaging techniques, particularly computer tomography, have improved fracture assessment, influencing surgical planning and outcomes. Surgery management remains the gold standard, with timing and techniques being crucial to minimize complications and costs.
- Citation: Lucchetta L, Mastroeni G, Rinonapoli G, Caraffa A, Gill SS, Pace V. Advancements in the diagnosis and management of complex trimalleolar ankle fractures: A comprehensive review. World J Orthop 2026; 17(1): 108554
- URL: https://www.wjgnet.com/2218-5836/full/v17/i1/108554.htm
- DOI: https://dx.doi.org/10.5312/wjo.v17.i1.108554
Complex ankle fractures pose significant challenges for clinicians, yet there remains a lack of clear, internationally accepted guidelines for either surgical or conservative management[1-3]. In the United States, ankle fractures occur at an incidence of 4.22 per 10000 person-years, accounting for approximately 3.4 billion dollars in annual healthcare ex
Complex ankle fractures represent 11% to 14% of all ankle fractures, with peak incidence between ages 50 and 69[3,6]. Among women, incidence is highest between ages 75 and 84[3,6]. Isolated unimalleolar fractures account for about 70% of cases, bimalleolar for 20%, and trimalleolar for 7%, while open ankle fractures comprise around 2% of cases[1-7]. The average cost per fracture is 27534 ± 19170 dollars, with 59% direct medical costs and 41% indirect costs from missed work[7]. Patients undergoing operative treatment incur significantly higher total (35413 dollars) and direct (23938 dollars) costs compared to those treated nonoperatively (14860 dollars and 3611 dollars, respectively), and also experience longer work absences[7].
For many patients, complex ankle fractures are life-altering injuries with profound effects on social and occupational functioning. Approximately 17.6% of previously employed individuals lose their jobs, and despite rehabilitation, 47% do not return to work within 5 years of injury[4]. Physical sequelae may include chronic pain, functional limitations, altered gait, and early post-traumatic arthritis, while psychological distress is also frequently reported[5]. These injuries are further associated with high complication rates and substantial morbidity and mortality[1-7]. Surgical intervention is typically indicated for unstable fracture patterns. However, ongoing debate surrounds both diagnostic approaches, such as the role of computed tomography, and optimal surgical techniques based on fracture type and patient-specific factors[1-7].
As such, this narrative review aims to provide a comprehensive state-of-the-art review of trimalleolar ankle fractures, focusing on the most widely utilized diagnostic protocols and treatment approaches. By exploring the current literature and examining the efficacy and outcomes of different interventions, this review synthesises current evidence on the diagnosis and management of trimalleolar ankle fractures, highlighting optimal strategies, contemporary practices, and emerging treatment trends.
A narrative review was conducted using PubMed (MEDLINE), Scopus, EMBASE, Cochrane Library, Google Scholar, and Web of Science. Keywords such as “complex ankle fractures”, “ankle fractures”, “management”, “trimalleolar”, “treat
Table 1 summarizes aetiology, classifications, and diagnostic approaches, while Table 2 outlines treatment options by fracture component. In addition, Table 3 presents a summary of optimal management approaches under different clinical scenarios, consolidating key practical recommendations for ease of reference.
| Section | Key points |
| Epidemiology and costs | High incidence in older adults, significant economic burden |
| Aetiology | Commonly caused by twisting, falls, or impact injuries |
| Classification | Multiple systems used (Pott, Lauge-Hansen, Weber, AO, CT-based) |
| Clinical evaluation | Pain, swelling, neurovascular risk; Tscherne classification guides soft tissue care |
| Diagnosis | Radiographs first-line; CT critical for surgical planning |
| Damage control | External fixation stabilizes open/high-risk fractures; Illizarov allows early weight-bearing |
| Timing of ORIF | ORIF within 6 days improves outcomes; delayed surgery raises infection risk |
| Lateral malleolus | Intramedullary nailing preferred for high-risk patients; locking plates also effective |
| Medial malleolus | ORIF standard; conservative treatment possible if anatomically reduced |
| Posterior malleolus | Fragment size and type guide fixation; direct posterior approach preferred for large PMF |
| Syndesmosis | Dynamic fixation (suture buttons) preferred over screws in some cases |
| Arthroscopy | Useful in active patients for intra-articular injury management |
| Deltoid ligament | Repair improves medial stability; especially in multi-ligamentous injuries |
| Postoperative care | OMAS, AOFAS scores used; early weight-bearing improves recovery but risks complications |
| Complications | Includes DVT, sepsis, MI, AKI; occur mostly within 30 days post-op |
| Fracture component | Main surgical options | Indications/notes | Advantages | Limitations/concerns |
| Lateral malleolus | Intramedullary fibular nailing; locking/antiglide plates | Weber B and C fractures; osteoporotic bone; high-risk soft tissue | Minimally invasive, preserves soft tissue, short operative time | Risk of hardware irritation; nail compliance issues |
| Medial malleolus | ORIF with single or dual screws; tension-band wiring; antiglide plating | Anatomically aligned vs displaced fractures; vertical/comminuted patterns (Herscovici types B-D) | Stable fixation, simple technique | Wire migration, need for hardware removal; risk of non-union |
| Posterior malleolus | Posterior plating (buttress/antiglide); anteroposterior screws | > 25% articular surface, talus dislocation, Haraguchi type II/III | Direct visualization, anatomical reduction, early weight-bearing | Increased operative time, wound complications |
| Tibiofibular syndesmosis | Cortical button fixation; high-strength suture constructs; traditional screws | Syndesmotic disruption or instability | Preserves physiological motion, less need for removal, fewer reoperations | Cost, learning curve; screw breakage if conventional fixation used |
| Scenario | Recommended approach | Supporting evidence/rationale |
| Open fracture with significant soft tissue injury | Initial external fixation ± orthoplastic input → staged ORIF once soft tissues permit | Reduces infection/compartment risk; Illizarov frame allows early weight-bearing[35-39] |
| Closed fracture with marked swelling | Temporary external fixation → delayed ORIF (ideally within 6 days) | Early stabilization with lower soft-tissue complication risk[40-47] |
| Posterior malleolus fragment > 25% articular surface or type II/III Haraguchi | Direct posterior approach with buttress plate/antiglide fixation | Improved reduction and prevention of post-traumatic arthritis[86-93] |
| Elderly/osteoporotic patient with lateral malleolus fracture | Intramedullary nailing or minimally invasive locking plate | Minimizes wound complications; preserves soft tissue integrity[48-53] |
| Younger/high-demand patient | Arthroscopic-assisted ORIF | Allows detection/repair of intra-articular injuries, better functional outcomes[68-73] |
| High-grade syndesmotic injury | Cortical button or high-strength suture fixation | Restores stability, avoids need for screw removal, facilitates early rehab[64-67] |
| Associated deltoid ligament injury with medial instability | Deltoid ligament repair ± ORIF | Improves reduction and long-term stability; supported in athletic/complex cases[94-102] |
Ankle fractures can result from various mechanisms of injury, most commonly involving twisting, impact, or crush forces. These may occur during sports activities, falls from height, or tripping. The extent of bony comminution and soft tissue damage is generally proportional to the energy of the trauma, and the resulting fracture pattern is closely associated with the specific mechanism of injury[1-5].
Several classification systems have been developed to categorize ankle fractures based on varying criteria. Pott[8] introduced a simple system based on the number of malleoli involved, as unimalleolar, bimalleolar, or trimalleolar fractures. The Lauge-Hansen classification[9] describes fracture patterns according to the position of the foot and the direction of the applied force during injury. Danis-Weber[10] focuses on the level of the fibular fracture in relation to the tibiofibular syndesmosis. The (arbeitsgemeinschaft fur osteosynthesefragen) system[11] offers a comprehensive numerical coding approach applicable across fracture types. More recently, computer tomography (CT)-based classifications have been developed to assess posterior malleolar fractures with greater precision[12-15].
Ankle fractures typically present with pain, swelling, deformity (which correlates with the degree of displacement), and, in high-energy injuries, may involve neurovascular compromise and significant soft tissue damage[1-3]. A thorough clinical assessment is essential, with particular attention to vascular and neurological status as well as the condition of the surrounding soft tissues. Soft tissue management in complex trimalleolar ankle fractures remains a key area of clinical debate. The integrity of the skin is a critical determinant of both the timing and nature of surgical intervention, as delayed wound healing can significantly complicate postoperative recovery.
The Tscherne classification system provides a standardized framework for evaluating soft tissue damage in both open and closed fractures, guiding decisions between immediate external fixation and acute open reduction and internal fixation (ORIF)[16]. Recent rehabilitation frameworks, such as the Protection, Elevation, Avoid Anti-Inflammatories, Compression, Education and Load, Optimism, Vascularization, Exercise protocols, have shifted away from traditional cryotherapy, emphasizing tissue healing and patient-centred care[17-22]. When fracture blisters are present, they should generally be left intact, as they tend to heal spontaneously[22]. Despite emerging recommendations, there remains no clear consensus on optimal soft tissue management, largely due to methodological limitations and bias within existing studies[23].
Radiographs are typically the first-line imaging modality for evaluating ankle fractures. The Ottawa Ankle and Foot Rules[24] serve as a valuable clinical tool to help identify patients who require radiographic assessment, thereby reducing unnecessary imaging, healthcare costs, and patient wait times in the emergency department[25]. A complete radiographic evaluation should include anteroposterior, mortise, and lateral views[26-28], while computed tomography is essential for complex ankle fractures to accurately define fracture patterns and guide surgical planning, altering the operative approach or positioning in approximately 44% of cases compared to radiographs alone[25-29].
Particular attention should be given to the posterior malleolus, as injuries in this region are often missed on standard radiographs[25-28]. CT imaging allows for accurate classification, such as with the Haraguchi system, and has been linked to improved outcomes when the fragment is surgically treated; patients undergoing ORIF demonstrated significantly higher American Orthopaedic Foot and Ankle Score (AOFAS) scores than those managed non-operatively (92.0 vs 82.5, P < 0.001)[30-33].
Moreover, CT arthrography has shown superior cartilage surface delineation in the ankle joint compared to magnetic resonance arthrography, particularly when using high-resolution protocols with one-millimetre slices and two-millimetre reconstructions, vs magnetic resonance imaging performed with 1.5 Tesla scanners and three-millimetre slices[34].
Ultrasound has shown promise as an alternative to radiographs for detecting ankle fractures, but its use remains limited to experienced radiologists due to the need for standardized training[26,27].
In open fractures, external fixation offers crucial initial stability while minimizing additional soft tissue trauma, thereby reducing the risk of compartment syndrome, infection, and delayed wound healing[35-37]. In these cases, the Illizarov technique has gained traction, as it permits early weight-bearing and facilitates a transition to definitive care[38].
In closed fractures with substantial swelling or elevated risk of soft tissue complications, external fixation serves as a temporizing measure. This strategy allows stabilization without immediate invasive surgery and is frequently used as a bridging technique prior to definitive internal fixation, striking a balance between early stabilization and soft tissue preservation[35-39].
The optimal timing for ORIF remains a topic of debate. Evidence suggests that performing surgery within six days post-injury yields better functional outcomes, including improved Olerud-Molander Ankle Score (OMAS) and Self-reported Foot and Ankle Score, along with reduced complication rates[40-42]. Delaying surgical intervention beyond six to seven days has been associated with increased risks of wound infection, poorer functional outcomes, and prolonged hospital stays[43-46].
In closed complex fractures, ORIF remains the gold standard. Soft tissue management is critical, especially given the use of larger, more robust fixation hardware in such cases[40-47]. For open fractures, the involvement of an orthoplastic team may allow for advanced wound management techniques. If the arterial blood supply to the limb is intact based on preoperative CT angiography, and the patient has no significant comorbidities, skin flaps may be considered for wound closure[47].
Intramedullary fibular nailing is a viable option for high-risk patients. In Weber B and C fractures, intramedullary nails (145 mm × 3.0 mm and 180 mm × 3.0 mm, respectively) with syndesmotic fixation provide sufficient biomechanical strength through a minimally invasive approach[48,49]. This method reduces surgical trauma, preserves soft tissue integrity, requires shorter operative time, and improves outcomes in osteoporotic bone[50,51]. Studies have reported high union rates, excellent functional outcomes, and low complication rates comparable to traditional ORIF in high-risk populations[52,53]. Dabash et al[48] demonstrated effective fracture reduction and excellent outcomes with no pos
Minimally invasive locking plates with small fragment screws are another option, particularly in cases with co
ORIF is the traditional approach for medial malleolus fractures in trimalleolar injuries. However, emerging evidence supports selective conservative management for anatomically aligned fractures following fibular stabilization, although up to 20 percent radiographic non-union has been reported[64-77]. Surgical options include open and percutaneous screw fixation. The necessity of dual screws has been questioned, especially in osteoporotic bone, where a single fully threaded screw may offer better stability[78,79].
Tension-band wiring is generally reserved for distal avulsion or comminuted fractures (Herscovici types B and C), but complications such as wire migration are common[80]. For vertical fractures (Herscovici type D), antiglide plating is preferred due to its superior biomechanical strength, despite requiring a larger surgical exposure[81-83]. New implants, such as headless or bioabsorbable screws, aim to reduce medial site pain and eliminate the need for removal, but further high-quality research is needed[84,85].
Posterior malleolus fractures, especially when comminuted, present surgical challenges. Historically, fixation was recommended only if the fragment exceeded 25 percent of the tibial articular surface. However, even smaller posterior fragments have been associated with poorer outcomes[86]. Mingo-Robinet et al[87] found better outcomes in fragments involving less than 25 percent of the joint surface, while a systematic review by Odak et al[88] found no correlation between fragment size and clinical results.
The Haraguchi classification guides treatment based on morphology. Type 1 fragments, when fixated, tend to yield favorable outcomes. In contrast, type 2 and 3 configurations, which are more complex, often result in worse prognoses[89].
In cases of talus dislocation or when the fragment involves more than 25 percent of the joint surface, surgical fixation is generally indicated due to the elevated risk of post-traumatic arthritis[86-89]. A modified posterior approach, with a 10-cm incision approximately one cm medial to the Achilles tendon, allows direct visualization and anatomical reduction of up to 91% of the posterior plafond[86-89]. When a medial malleolus fracture is also present, the incision can be extended distally to avoid additional surgical sites.
Although there is no consensus on the optimal fixation method, buttress plates, antiglide plates, and anteroposterior screws remain commonly used. Implant selection should be based on surgeon experience and aimed at achieving stable fixation that permits early weight-bearing[90,91]. However, treating the posterior fragment adds operative time, blood loss, and a higher risk of wound complications[32,92].
Larger posterior fragments, greater than 10 percent of the articular surface, are associated with decreased range of motion in the talocrural and midfoot joints and worse patient-reported outcomes[90-93].
Conventional syndesmotic fixation with screws restricts physiological motion of the distal tibiofibular joint and may necessitate later removal. Consequently, alternative techniques are being explored[64,65]. Lehtola et al[66] compared syndesmotic screws and cortical button fixation, reporting similar reduction maintenance at seven-year follow-up with fewer complications in the cortical button group.
Zhu et al[67] introduced a method using high-strength polyester sutures passed through a bone tunnel, avoiding screw removal and promoting faster recovery. In elderly patients, Pearce et al[47] demonstrated that a tibiofibular construct using multiple cortex screws through a posterolateral fibular plate provides stable fixation and facilitates early weight-bearing, which is critical to reducing immobilization-related complications.
Arthroscopic-assisted ORIF (AORIF) is increasingly used for acute trimalleolar fractures, particularly in younger, high-demand patients[68,69]. This technique enables direct evaluation and management of associated intra-articular injuries, including chondral damage, deltoid ligament tears, and syndesmotic instability[70-72]. While patients treated with AORIF achieve superior functional outcomes compared to those undergoing traditional ORIF, the cost-effectiveness and potential complications of AORIF require further investigation[73-75].
Ligamentous integrity is as critical as bony alignment in the comprehensive assessment of ankle fractures. In cases of high-grade instability, including syndesmotic or multi-ligamentous injuries, deltoid ligament repair (DLR) may be indicated to restore medial clear space stability[94]. Surgical reinsertion of the deltoid ligament to the medial malleolus or talus is typically performed via a direct open approach. For the superficial deltoid ligament, this is usually 5 mm distal to the tip of the medial malleolus. The deep deltoid ligament is accessed through a longitudinal medial approach, often utilizing micro bone sutures or suture anchors[95,96].
Arthroscopic assistance is increasingly favoured in complex fractures, particularly in highly functional patients such as professional athletes. This approach allows direct visualization of intra-articular lesions and enables early debridement and repair of damaged structures[97]. Although consensus is lacking, growing evidence supports DLR in acute ankle fractures, with studies reporting improved long-term anatomical reduction and reduced pain scores[72,98-102]. As such, DLR remains an important consideration in the surgical management of unstable ankle injuries.
The choice of surgical technique must ultimately be individualized, integrating fracture morphology, patient-specific factors, and diagnostic findings. Posterior malleolar fractures with complex or type II/III Haraguchi morphology are best addressed through a direct posterior approach with plate fixation, while smaller, non-displaced fragments may be managed conservatively or with anterior-to-posterior screws[86-90]. In elderly or osteoporotic patients, intramedullary fibular nailing or locking plate fixation may reduce wound complications compared to traditional plating[49]. Younger, high-demand patients may benefit from AORIF, which permits direct assessment of intra-articular lesions[68-70]. CT-based classifications and the condition of the surrounding soft tissues remain key determinants in deciding between immediate fixation, staged management with external fixation, or minimally invasive techniques[25]. Thus, both fracture-specific and patient-specific factors should guide the operative plan, emphasizing the importance of individualized surgical decision-making.
Following surgical treatment of trimalleolar ankle fractures, patients should undergo regular follow-up using stan
Early unprotected weight-bearing is increasingly promoted as part of the “get up and walk” approach[108-110]. Dehghan et al[108] demonstrated that this strategy facilitated a faster return to work (mean 4.1 weeks vs 5.7-7.0 weeks with immobilization). Park et al[109] found no significant difference in OMAS scores between weight-bearing and immobilized patients. Keene et al[110] reported that early mobilization may reduce thrombotic risk, though possibly at the expense of higher rates of infection, fixation failure, or reoperation. The mechanisms underlying these complications remain unclear.
Despite advances, many patients continue to experience suboptimal outcomes, including swelling, limited range of motion, and impaired ankle function at around 4.5 months postoperatively[111]. Gait analyses reveal abnormal walking patterns, asymmetric plantar pressure distribution in the hindfoot and forefoot, and altered muscle activity in the tibialis anterior and peroneus longus following fractures[112].
Common postoperative complications following trimalleolar ankle fractures include myocardial infarction, pneumonia, acute kidney injury, urinary tract infection, pulmonary embolism, sepsis, deep vein thrombosis, and surgical site infection[1-11]. Bohl et al[42] reported that surgical site infections, sepsis, and deep vein thrombosis typically occur within 30 days postoperatively. Additionally, bi- and trimalleolar fractures are associated with an earlier onset of myocardial infarction, urinary tract infection, and sepsis compared to unimalleolar and trimalleolar fractures. Acute kidney injury tends to present later in hospitalized patients than in outpatients, whereas urinary tract infections occur earlier in inpatient settings[1-11,42].
Two areas of ankle fracture management remain particularly debated: Fixation of the posterior malleolus and mana
The role of syndesmotic screw management also remains unresolved. Rigid screws restrict physiological tibiofibular motion[64,65], but studies differ on the need for routine removal. Some advocate removal to avoid screw breakage[113,114], whereas others report equivalent or better outcomes when screws are retained or left to break in situ[115]. Alternatives such as cortical buttons[66], high-strength suture constructs[67], and bioabsorbable screws[116] offer dynamic fixation and may reduce the need for secondary procedures.
Together, these debates highlight the complexity of decision-making in trimalleolar fracture care, reinforcing the importance of tailoring treatment to fracture morphology, patient-specific factors, and surgeon expertise. Table 3 consolidates best-practice recommendations across common clinical scenarios, providing a practical framework while acknowledging areas where consensus is lacking.
Future research should prioritize large-scale, multicentred randomized controlled trials that compare commonly used surgical techniques across diverse fracture patterns and patient populations. There is also a pressing need for stan
Trimalleolar ankle fractures are complex injuries with high incidence and significant economic impact. Advanced imaging, particularly CT, has improved fracture assessment and surgical planning. Surgery remains the gold standard, with timing and technique critical to reducing complications and costs. Minimally invasive methods for lateral malleolus fractures and novel syndesmosis repair techniques show promise in minimizing reoperations. Management benefits from a multidisciplinary approach guided by Advanced Trauma Life Support principles, with effective communication, leadership, and attention to rehabilitation playing key roles. Despite progress, standardized treatment protocols are still lacking, highlighting the need for further research to improve outcomes and reduce healthcare burdens. Current evidence supports an individualized approach guided by fracture morphology, comorbidities, and soft tissue condition, with early orthoplastic input in complex cases. While formal algorithms continue to evolve, early ORIF and selective use of ad
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