Molecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis

doi:10.5312/wjo.v17.i1.111911

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Orthop. Jan 18, 2026; 17(1): 111911
Published online Jan 18, 2026. doi: 10.5312/wjo.v17.i1.111911

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Figure 1 Molecular mechanisms of molecular hydrogen therapy in musculoskeletal ailments. ROS: Reactive oxygen species; NF-κB: Nuclear factor-kappa B; TNF: Tumor necrosis factor; IL: Interleukin; JNK: C-Jun N-terminal kinase; ATP: Adenosine triphosphate; Nrf2: Nuclear factor erythroid 2-related factor 2; Keap1: Kelch-like ECH-associated protein 1; Wnt: Wingless/integrated.

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Figure 2 Molecular hydrogen -mediated nuclear factor erythroid 2-related factor 2/Kelch-like ECH associated protein 1 signaling pathway. Keap1: Kelch-like ECH-associated protein 1; Nrf2: Nuclear factor erythroid 2-related factor 2; sMaf: Small Maf protein; ARE: Antioxidant response element.

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Figure 3 Molecular hydrogen therapy in musculoskeletal ailments.

Citation: Jeyaraman N, Jeyaraman M, Ramasubramanian S, Murugan S, Nallakumarasamy A, Muthu S. Molecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis. World J Orthop 2026; 17(1): 111911
URL: https://www.wjgnet.com/2218-5836/full/v17/i1/111911.htm
DOI: https://dx.doi.org/10.5312/wjo.v17.i1.111911