Nanotechnology for pain management in orthopedic surgery

doi:10.5312/wjo.v16.i10.110009

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Oct 18, 2025 (publication date) through Nov 22, 2025

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Orthop. Oct 18, 2025; 16(10): 110009
Published online Oct 18, 2025. doi: 10.5312/wjo.v16.i10.110009

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Figure 1 Summary of the most important information on the use of nanotechnology-based transporters in the treatment of postoperative pain in orthopedic surgery. ACB: Adductor canal block; THA: Total hip arthroplasty; TKA: Total knee arthroplasty; EREM: Extended-release epidural morphine; NRS: Numeric rating scale; PR: Prolonged release; HCl: Hydrochloride.

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Figure 2 Schematic representation of the NeuroCuple™ device/patch.

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Figure 3 Peripheral mechanism of action of the NeuroCuple™ device.

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Figure 4 Kailo Pain Patch (Sandy, UT, United States).

Citation: Rodriguez-Merchan EC, De Andres-Ares J, Delgado-Martinez AD, Ribbans WJ. Nanotechnology for pain management in orthopedic surgery. World J Orthop 2025; 16(10): 110009
URL: https://www.wjgnet.com/2218-5836/full/v16/i10/110009.htm
DOI: https://dx.doi.org/10.5312/wjo.v16.i10.110009